ea0021p361 | Steroids | SFEBES2009
, Martins Joana
, Clark Andrew
Glucocorticoids (GCs) are steroid hormones, products of the hypothalamicpituitaryadrenal axis. Synthetic GCs, such as dexamethasone, have been widely used in the treatment of inflammatory diseases like rheumatoid arthritis or asthma, but their long-term use causes severe side effects (osteoporosis, diabetes, hypertension, etc). The ligand-bound GC receptor (GR) can activate gene expression via binding to GC response elements (GREs), a mechanism known as transactiva...