ea0081p103 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022
Tozzi Rossella
, Masi Davide
, Cipriani Fiammetta
, Elena Spoltore Maria
, Contini Savina
, Watanabe Mikiko
, Basciani Sabrina
, Lubrano Carla
, Gnessi Lucio
, Mariani Stefania
Background and aim: Sirtuin1 (SIRT1) and sclerostin play important roles in adipose tissue and bone metabolism. SIRT1 pharmacological induction improves bone quality both in murine and human models and- as adiposity increases – its expression decreases both in peripheral tissues and blood. Sclerostin reduces osteoblasts’ differentiation and mineralization and is associated with DMT2, obesity and cardiovascular risk. We evaluated the circulating SIRT1 and sclerostin r...