ea0037oc5.5 | Steroids, developmental and paediatric endocrinology | ECE2015
Joustra Sjoerd
, Roelfsema Ferdinand
, Endert Erik
, Ballieux Bart
, van Trotsenburg Paul
, Fliers Eric
, Corssmit Noortje
, Bernard Daniel
, Oostdijk Wilma
, Wit Jan-Maarten
, Pereira Alberto
, Biermasz Nienke
Context: Loss-of-function of immunoglobulin superfamily 1 (IGSF1) causes an X-linked syndrome of central hypothyroidism, macroorchidism, and variable prolactin deficiency, GH deficiency in childhood, delayed pubertal testosterone rise, and/or obesity. The clinical features advert towards a pivotal role for IGSF1 in the pituitary gland, but detailed knowledge on pituitary hormone secretion in this syndrome is lacking.Objective: To study detailed ...