Searchable abstracts of presentations at key conferences in endocrinology

ea0065p138 | Endocrine Neoplasia and Endocrine Consequences of Living with and Beyond Cancer | SFEBES2019

Targeting oestrogen synthesis and action as a novel therapy for colorectal cancer

Sidhu Daljit , Haime Hope , Pidd Aidan , Taylor Angela , Cox Liam , Foster Paul

Colorectal cancers (CRC) represent 9.4% of all cancers, with about 42 000 new UK cases per year. Current treatment involves surgical resection followed by radio- and chemo-therapy. 5-Fluorouracil is the standard post-operative chemotherapy although tolerance is poor due to dose-limiting toxicities and drug-resistance. New treatment strategies are therefore sorely needed. One emerging chemotherapeutic option is to target oestrogen metabolism. Our novel work rev...

ea0070oc5.4 | Thyroid | ECE2020

Drug repurposing identifies inhibitors of the proteostasis network to augment radioiodine uptake in combinatorial approaches targeting thyroid cancer

Read Martin , Brookes Katie , Fletcher Alice , Thornton Caitlin , Alshahrani Mohammed , Khan Rashida , Nieto Hannah , Adcock Holly , Webster Jamie , Cox Liam , Alderwick Luke , Boelaert Kristien , Smith Vicki , McCabe Christopher

New combinatorial drug strategies are urgently needed to improve radioiodine (RAI) uptake and efficiently ablate thyroid cancer cells, thereby reducing the risk of recurrent disease. Drug repurposing offers the promise of identifying already approved compounds capable of inducing sodium iodide symporter (NIS) function to enhance iodide uptake. However, a lack of thyroid cell-based assays amenable to high-throughput screening has limited progress. We utilised the mutated yellow...