ea0012oc11 | Placenta, bone and genetics | SFE2006
Forhead AJ
, Lamb CA
, Franko KL
, Cripps RL
, Ozanne S
, Blache D
, Fowden AL
Although leptin is important in the control of appetite and energy expenditure in adulthood, its actions before birth are unclear. This study investigated the effects of leptin on hepatic carbohydrate metabolism and insulin signalling in fetal sheep. Twelve sheep fetuses were chronically-catheterised at 115120 d of gestation (term 145±2 d), and infused intravenously with saline (0.9% NaCl; n=6) or recombinant ovine leptin (0.51.0 mg/kg/d; Protein Labora...