Searchable abstracts of presentations at key conferences in endocrinology

ea0014oc11.4 | Reproductive endocrinology II | ECE2007

EGFR ligands mediate key events of female reproduction: reduced litter size due to impaired fertilization in a transgenic mouse model

Schneider Marlon R. , Gratao Ana A. , Dahlhoff Maik , Sinowatz Fred , Wolf Eckhard

EGFR ligands, a family of seven related peptide growth factors, are emerging as key factors regulating different aspects of female reproduction including oocyte maturation and ovulation, and implantation. Betacellulin (BTC) is a rather neglected EGFR ligand whose biological activities have been mostly associated with the endocrine pancreas. During the routine breeding of recently established BTC transgenic mouse lines (Schneider et al., Endocrinology 146, 5237–5246, 2005)...

ea0014p21 | (1) | ECE2007

Improved glucose metabolism and altered pancreatic structure in transgenic mice overexpressing betacellulin

Dahlhoff Maik , Herbach Nadja , Wanke Rüdiger , Wolf Eckhard , Schneider Marlon R.

Betacellulin, one of several peptides activating the EGFR (ErbB1) and related receptors, is a multipotent growth factor known to posses the unique ability to promote growth and differentiation of pancreatic β-cells.We investigated the effects of betacellulin overexpression in a recently established transgenic mouse model (Schneider et al., Endocrinology 146, 5237–5246, 2005). In transgenic animals, overall glucose metabolism was improved...