Searchable abstracts of presentations at key conferences in endocrinology

ea0085p82 | Pituitary and Growth 2 | BSPED2022

Glucagon tolerance tests in a tertiary paediatric centre: an evidence-base for protocol refinement

Farley Hannah , Gilbert Jennifer , Daskas Nikolaos

Background: The glucagon tolerance test (GTT) is used to diagnose growth hormone deficiency (GHD) in younger children or in patients where the insulin tolerance test is contraindicated. We assessed GTTs carried out over five years in a tertiary paediatric centre to assess growth hormone (GH) and cortisol axes. The aim was to assess at which time points the GH peak was observed, and assess whether any predictive value is gained from demographics or IGF-1....

ea0030oc2.9 | Oral Communications 2 | BSPED2012

GH neuro-secretory dysfunction following traumatic brain injury in childhood

Daskas Nikolaos , Sharples Peta , Crowne Elizabeth

GH deficiency is recognised as a complication of adult traumatic brain injury (TBI) but there are conflicting data in children possibly due to the influences such as age at TBI, trauma mechanism but also by timing, method and criteria of hormonal evaluation.Objectives: To assess the long-term impact of TBI on the GH–IGF1 axis following TBI in childhood.Patients: Longitudinal study of 28 participants with a history of moderate/...

ea0078OC9.1 | Oral Communications 9 | BSPED2021

Variability in the diagnosis of growth hormone deficiency using dynamic tests. Time for robust pre-test criteria?

Zilber Eva , Cramer Rebecca , Crowne Elizabeth , Ryan Fiona , Daskas Nikolaos

Background: Insulin tolerance test (ITT) is the gold-standard investigation in children with suspected growth hormone deficiency (GHD). Despite their benefits, ITTs are resource intensive, potentially dangerous and can result in unnecessary treatment due to false positive results in children that are at low risk for GHD.Methods: Retrospective analysis of all paediatric patients undergoing an ITT in two tertiary hospitals in the UK (centre A between 2017-...

ea0030p37 | (1) | BSPED2012

Long-term morbidity after traumatic brain injury in childhood: fatigue, impact on cognition, health related quality of life and abnormal GH status

Daskas Nikolaos , Miller Helen , Leonards Ute , Sharples Peta , Crowne Elizabeth

Objectives: To determine long-term functional outcome following traumatic brain injury (TBI) in childhood.Patients: Longitudinal study of 49 participants with TBI (21 mild, 28 moderate/severe TBI) and 16 healthy controls matched for age, gender and socioeconomic status. Age at TBI (median (range)) 11.8 (1–16) years; 17 were prepubertal, 16 peripubertal, 16 postpubertal. Age at study 19.7 (10–26) years, time post TBI 8.6 (5.8–10.8) years. A...

ea0033p78 | (1) | BSPED2013

How to improve the “gold standard” – the insulin tolerance test (ITT) revisited

Daskas Nikolaos , Bowron Ann , Burren Christine , Woldersdorf Wolf , Barton John , Crowne Elizabeth

Background: The ITT has been said to be the gold standard for diagnosing GH deficiency (GHD) for 50 years. The original 0, 20, 30, 60, 90 and 120 min time points are still used in many but a survey of current UK paediatric ITT protocols identified several variations.Objective and hypotheses: To identify optimal GH sampling time points to avoid over diagnosis of GHD.Methods: Results of 502 paediatric ITTs using two different samplin...