Searchable abstracts of presentations at key conferences in endocrinology

ea0045oc8.7 | Oral Communications 8- Diabetes | BSPED2016

Clarifying the natural history of human insulin receptoropathy

Johnston David , Bulger David , Harris Julie , Semple Robert

Background: Insulin resistance is the reduced responsiveness of the body to the glucose-lowering activity of insulin. It is usually associated with obesity, but in a minority of patients, this is not the case. Single gene mutations can often be found in such patients, some of which affect the insulin receptor (INSR). There is a spectrum of genetic insulin receptoropathies. These can be considered as two groups. One group comprises rare, severe, autosomal recessive disorders: D...