Searchable abstracts of presentations at key conferences in endocrinology

ea0019p55 | Clinical practice/governance and case reports | SFEBES2009

Following a cardiac arrest in this seemingly healthy 28-year-old, all became clear

de Lloyd Anna , Obuobie Kofi

After suffering three spontaneous pneumothoraces, Mr A was due to have definitive treatment in the form of video-assisted thoracoscopy and pleurodesis. Soon after ‘induction of anaesthesia’ he developed severe hypertension; 130/80 →300/220 associated with global high take off and ST elevation on the ECG. Labetol was given i.v. after which the blood pressure became unrecordable and an EMD cardiac arrest ensued. Three cycles of cardiac massage and two boluses of ...

ea0025p194 | Endocrine tumours and neoplasia | SFEBES2011

Bowel obstruction can be the presenting symptom of phaeochromocytoma

de Lloyd Anna , Davies J Stephen , Scott-Coombes David

We describe the case of two patients who presented with non-mechanical bowel obstruction as a consequence of an underlying, undiagnosed Phaeochromocytoma. The first patient was referred in to the surgical team by his GP with signs and symptoms of small bowel obstruction. He described abdominal pain, distension and vomiting and had not opened his bowels for a week. The X-ray supported the clinical diagnosis and he went on to have an abdominal CT scan. The scan did not identify ...

ea0031p38 | Clinical biochemistry | SFEBES2013

Development of an inductively coupled plasma-mass spectrometry method for measurement of urine iodine and assessment of iodine status in subclinical hypothyroidism

Jones Katie , Rogers Joanne , De Lloyd Anna , Rees Aled , Ludgate Marian , Evans Carol

Iodine deficiency may lead to reduced thyroid hormone production and ultimately hypothyroidism. The UK has previously been considered to be iodine sufficient, however recent evidence suggests the UK may be iodine deficient. Iodine status can be assessed in several ways, including measurement of urinary iodine excretion, for which inductively coupled plasma-mass spectrometry (ICP-MS) is considered the gold standard method.An ICP-MS method for determinatio...

ea0021p156 | Diabetes and metabolism | SFEBES2009

Impact of extra cellular matrix changes on adipogenesis

Zhang Lei , Steadman Robert , de Lloyd Anna , Ham Jack , Rees Aled , Ludgate Marian

Obesity (excess adipose tissue generated by hypertrophy and hyperplasia) predisposes to poor health. Adipogenesis (hyperplasia) involves the differentiation of adherent preadipocytes into non-adherent adipocytes and is accompanied by alterations to the extracellular matrix of which hyaluronan (HA) is a component. Used in vitro to promote lineage specific differentiation, little is known of HA’s role in adipogenesis. We hypothesise that HA modifications must occur d...

ea0037gp.26.03 | Thyroid – hypothyroidism | ECE2015

Adverse metabolic correlations relate to free T3 levels in subclinical hypothyroidism; common FOXE1 polymorphisms associate with blood pressure

de Lloyd Anna , Muller Ilaria , Dodd Alan , Bakhsh Ameen , Durrant Hilary , Zhang Lei , Evans Carol , Rees Aled , Ludgate Marian

Introduction: The effects of mild subclinical hypothyroidism (SH; TSH <10 mU/l) on metabolic outcomes are unclear. This may relate to differences in aetiology, including thyroid autoimmunity or genetic factors such as TSH-receptor mutations (TSHR-M) and FOXE1 polyalanine tract length (FOXE1–PTL) polymorphisms, which are associated with altered thyroid function. We hypothesised that the metabolic manifestations of SH may depend upon its aetiology.<p class="abstext"...

ea0037ep253 | Calcium and Vitamin D metabolism | ECE2015

TSH and free-T3 correlate negatively and independently with bone mineral density in adults with subclinical hypothyroidism

de Lloyd Anna , Muller Ilaria , Dodd Alan , Durrant Hilary , Pettit Rebecca , Darlington Sarah , Zhang Lei , Evans Carol , Rees Aled , Ludgate Marian

The role of the thyrotropin receptor (TSHR) in bone is unclear. TSHR-deficient mice have low bone mineral density (BMD) and focal osteosclerosis despite normal thyroid hormones (suggesting TSHR function, in bone, is important). Subclinical hypothyroidism (SH) has various aetiologies including thyroid autoimmunity (TA) and inactivating TSHR mutations (TSHR-M). In TSHR-deficiency & TSH-M elevated TSH compensates for reduced TSHR function, whereas in TA it compensates for red...