Searchable abstracts of presentations at key conferences in endocrinology
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17th European Congress of Endocrinology

Guided Posters

Thyroid – hypothyroidism

ea0037gp.26.01 | Thyroid – hypothyroidism | ECE2015

Quality of life in primary hypothyroidism after long-term levothyroxine replacement

Djurovic Marina , Pereira Alberto , Vasovic Olga , Jemuovic Zvezdana , Pavlovic Dragan , Petakov Milan , Salak Biljana , Damjanovic Svetozar

Introduction: There is an increasing awareness for intrinsic imperfections of endocrine replacement therapy affecting general well-being in the long-term. For thyroid hormone, many factors affect the variable responses to hormone replacement, like common genetic variations in deiodinase and thyroid hormone transport proteins, and the inability to provide adequate individual combined T4 and T3 therapy. Despite levothyroxine (L-T4)...

ea0037gp.26.02 | Thyroid – hypothyroidism | ECE2015

High serum IgG4 concentrations in patients with Hashimoto's thyroiditis

Poplawska-Kita Anna , Kosciuszko-Zdrodowska Maria , Siewko Katarzyna , Telejko Beata , Hryniewicka Justyna , Milewski Robert , Szelachowska Malgorzata , Gorska Maria

Purpose: Recent reports strongly suggest that at least some cases of Hashimoto’s thyroiditis (HT) may be closely associated with IgG4-related disease. In the present study we aimed to find out, whether the measurement of serum IgG4 allows for an identification of distinct types of HT, with different clinical, sonographic and serologic characteristics.Methods: The group studied consisted of 53 patients with HT and 28 healthy individuals. All the part...

ea0037gp.26.03 | Thyroid – hypothyroidism | ECE2015

Adverse metabolic correlations relate to free T3 levels in subclinical hypothyroidism; common FOXE1 polymorphisms associate with blood pressure

de Lloyd Anna , Muller Ilaria , Dodd Alan , Bakhsh Ameen , Durrant Hilary , Zhang Lei , Evans Carol , Rees Aled , Ludgate Marian

Introduction: The effects of mild subclinical hypothyroidism (SH; TSH <10 mU/l) on metabolic outcomes are unclear. This may relate to differences in aetiology, including thyroid autoimmunity or genetic factors such as TSH-receptor mutations (TSHR-M) and FOXE1 polyalanine tract length (FOXE1–PTL) polymorphisms, which are associated with altered thyroid function. We hypothesised that the metabolic manifestations of SH may depend upon its aetiology.<p class="abstext"...

ea0037gp.26.04 | Thyroid – hypothyroidism | ECE2015

Nkx2.5 gene mutations are not associated with congenital heart defects in children with thyroid dysgenesis

Ramos Helton Estrela , de Oliveira Cerqueira Taise Lima , Ramos Yane Rocha , Leite Paula , Santos Jailciele , San Martin Daniel , Costa Anabel Goes , Fernandes Vladimir , Strappa Giorgia , de Jesus Mariana Souza , Amorim Tatiana , Ladeia Ana Marice

Context: Several specific transcriptional factors, in view of their important role in thyroid organogenesis and thyroid specific gene expression, would be strong candidate genes for the etiology of TD. The homeobox transcription factor NKX2.5 was thought to be only required for the organogenesis of the heart tube. However, NKX2.5−/− embryos also exhibited a smaller outgrowing thyroid bud. Indeed, several loss ...

ea0037gp.26.05 | Thyroid – hypothyroidism | ECE2015

Oral liquid thyroxine assumed at breakfast: preliminary results of the TICO study

Pirola Ilenia , Formenti Annamaria , Daffini Linda , Cristiano Alessandra , Gandossi Elena , Pini Floriana , Cappelli Carlo

Many conditions may interfere with intestinal absorption of levothyroxine (L-T4). In addition, it has been demonstrated a failure in the normalisation of TSH values in patients consuming L-T4 tablets with coffee or with water followed by coffee taken shortly afterwards. Recent studies showed that oral liquid L-T4 could remove the problem of L-T4 malabsorption by coffee and f...

ea0037gp.26.06 | Thyroid – hypothyroidism | ECE2015

Analysis of hypothyroidism in patients admitted to internal medicine wards in Spain 2005–2012

Penso Rona , Duran Alejandra , Gracia Teresa Ruiz , Crespo Irene , Ortola Ana , De Miguel Paz , Mendez Manuel , Nunez Karla , Lopez Judith , Marco Javier

Introduction: Hypothyroidism (hT) is a very common disease that can affect inpatients prognosis. We analysed the clinical profile of patients with hT admitted to Internal Medicine using a large clinical-administrative database.Methods: A descriptive analysis based on the minimum-data-set database of the Spanish National health System of patients who were discharged from the services of Internal Medicine with the diagnoses of hT during 2005–2012 was ...

ea0037gp.26.07 | Thyroid – hypothyroidism | ECE2015

Cardiovascular risk factors in autoimmune thyroiditis and subclinical hypothyroidism

Neves Celestino , Esteves Cesar , Neves Joao Sergio , Sokhatska Oksana , Pereira Miguel , Palmares Carmo , Dias Camila , Carvalho Davide , Delgado Luis , Medina Jose Luis

Introduction: Subclinical hypothyroidism appears to be related with an increased risk of cardiovascular disease. It was our objective to evaluate the relationship between autoimmune thyroiditis, subclinical hypothyroidism, and cardiovascular risk factors.Methods: We evaluated thyroid function tests, autoimmunity, total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, ApoA1, ApoB, Lp(a), homocysteine, high sensibility CPR, folic acid, vitamin...

ea0037gp.26.08 | Thyroid – hypothyroidism | ECE2015

Prevalence and clinical associations of calcium-sensing receptor and NALP5 autoantibodies in patients with autoimmune polyendocrine syndrome type 1

Habibullah Mahmoud , Kluger Nicolas , Ranki Annamari , Sandhu Harpreet , Krohn Kai , Weetman Anthony , Kemp Helen

Rationale and hypothesis: Autoimmune polyendocrine syndrome type 1 (APS1) is a rare autosomal recessive disease which is characterised by chronic mucocutaneous candidiasis and multiple autoimmune endocrinopathies and results from mutations in the autoimmune regulator (AIRE) gene. Approximately 80% of APS1 patients present with hypoparathyroidism which is suggested to result from aberrant immune responses against the parathyroid gland. As patients typically display org...

ea0037gp.26.09 | Thyroid – hypothyroidism | ECE2015

No effect of Thr92Ala DIO2 polymorphisms on thyroid parameters, health-related quality of life, and cognitive functioning

Wolffenbuttel Bruce H R , van Loon Hannah C M , Elderson Martin F , van Vliet-Ostaptchouk Jana V , Wouters Hanneke J C M , Kobold Anneke Muller , Links Thera P , Slagter Sandra N , van der Klauw Melanie M

Introduction: The Thr92Ala polymorphism of deiodinase 2 (DIO2) is associated with increased expression in the brain of genes associated with oxidative stress, and may predict favourable response to combination thyroxine (L-T4) plus triiodothyronine (T3) therapy. We examined whether the Thr92Ala polymorphism (rs225014) was associated with differences in thyroid hormone parameters, health-related quality of life (HR-QOL) and cognitive functio...

ea0037gp.26.10 | Thyroid – hypothyroidism | ECE2015

HLA-DR in Hashimoto's thyroiditis

Jabrocka-Hybel Agata , Skalniak Anna , Pietkowski Jakub , Turek-Jabrocka Renata , Vyhouskaya Palina , Tsang Adrian , Lizis-Kolus Katarzyna , Sokolowski Grzegorz , Pach Dorota , Hubalewska-Dydejczyk Alicja

Background: The human leukocyte antigen (HLA) cluster is a genetic region that has been associated with multiple autoimmune disorders, also with autoimmune thyroid diseases. Plenty attempts to establish the significance of class II HLA-DR in Hashimoto’s thyroiditis (HT) development were undertaken in the past; however, reports are rather divergent. This might be caused by different criteria used to diagnose HT. There is however an alternative hypothesis, according to whic...