Searchable abstracts of presentations at key conferences in endocrinology

ea0063p18 | Adrenal and Neuroendocrine Tumours 1 | ECE2019

Evaluating the applicability of urinary miR-483-5p as a non-invasive marker in adrenocortical cancer patients

Decmann Abel , Bancos Irina , Thomas Melinda A , Turai Peter , Perge Pal , Toth Miklos , Patocs Attila , Igaz Peter

Introduction: Minimally invasive blood-borne circulating microRNAs might be used for the preoperative differentiation of adrenocortical carcinoma (ACC) and adrenocortical adenoma (ACA). Circulating hsa-miR-483-5p is so far the best microRNA biomarker of ACC. To the best of our knowledge, there have been no studies concerning the potential applicability of urinary has-miR-483-5p as a non-invasive biomarker of ACC and its correlation with plasma hsa-miR-483...

ea0041gp114 | Endocrine Tumours | ECE2016

Proteomic and pathway analysis of adrenocortical cancer in an in vivo xenograft study

Nagy Zoltan , Baghy Kornelia , Hunyadi-Gulyas Eva , Decmann Abel , Kovalszky Ilona , Medzihradszky Katalin , Racz Karoly , Patocs Attila , Igaz Peter

Background: Few effective medical treatment options are available for adrenocortical carcinoma (ACC). Intensive efforts are therefore going on for exploring novel pathways and treatment targets.Objective: To perform a proteomic and pathway analysis on a 9-cisRA (9-cis retinoic acid) and mitotane-treated ACC xenograft model.Methods: 43 male SCID mice xenografted with NCI-H295R cells were treated in four groups (i. control, ii. 5 mg/...

ea0056gp37 | Adrenal cortex | ECE2018

MicroRNA expression profiling in adrenal myelolipoma, adrenocortical cancer and adrenocortical adenoma

Decmann Abel , Perge Pal , Nyiro Gabor , Darvasi Otto , Liko Istvan , Borka Katalin , Micsik Tamas , Patocs Attila , Igaz Peter

Background: Adrenal myelolipoma (AML) is a relatively common and invariably benign tumor composed of adipose tissue and hematopoietic elements. Due to the variable proportion of fat and hematopoietic elements, it is sometimes challenging to differentiate AML from adrenocortical carcinoma (ACC). MicroRNAs have been identified as promising biomarkers in many tumors, including adrenocortical neoplasms, but the microRNA expression of adrenal myelolipoma has not been investigated, ...

ea0063gp198 | Adrenal and Neuroendocrine - Clinical | ECE2019

Analysis of circulating microRNAs in primary aldosteronism

Decmann Abel , Nyirő Gabor , Darvasi Otto , Turai Peter , Bancos Irina , Pezzani Raffaele , Kraljevic Ivana , Kastelan Darko , Parasiliti-Caprino Mirko , Nirschl Nina , Heinrich Daniel , Patocs Attila , Igaz Peter

Introduction: Primary aldosteronism (PA) is a major cause of secondary hypertension. The two major forms of sporadic PA (aldosterone producing adenoma – APA and bilateral adrenal hyperplasia – BAH) can only be reliably differentiated by adrenal venous sampling (AVS). Several mutations have been described for APA, but the pathogenesis of BAH is poorly elucidated. Differentiation of APA and BAH is clinically pivotal, as their treatment is different. There is no blood-b...

ea0049gp3 | Adrenal 1 | ECE2017

Exosomal hsa-miR-483-5p and hsa-miR-101 are potential minimally invasive biomarkers of adrenocortical carcinoma

Perge Pal , Butz Henriett , Pezzani Raffaele , Bancos Irina , Nagy Zoltan , Decmann Abel , Luconi Michaela , Mannelli Massimo , Buzas Edit Iren , Toth Miklos , Boscaro Marco , Patocs Attila , Igaz Peter

Background: Extracellular vesicles (exosomes, microvesicles) shed from tumor cells containing microRNAs can be exploited as markers of malignancy. The preoperative diagnosis of adrenocortical malignancy is difficult and microRNAs have proved useful in the diagnosis of many tumors, including adrenocortical cancer (ACC), but there have no studies to date on extracellular vesicle associated microRNAs in ACC.Aim: To evaluate the diagnostic potential of extra...