Searchable abstracts of presentations at key conferences in endocrinology
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21st European Congress of Endocrinology

Lyon, France
18 May 2019 - 21 May 2019

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18-21 May 2019, Lyon, France

Guided Posters

Adrenal and Neuroendocrine - Clinical

ea0063gp187 | Adrenal and Neuroendocrine - Clinical | ECE2019

Primary adrenal insufficiency in children: results from a large nationwide cohort

Improda Nicola , Esposito Andrea , Capalbo Donatella , Cappa Marco , Ferro Giusy , Balsamo Antonio , Baronio Federico , Russo Gianni , Lascio Alessandra Di , Greggio Nella Augusta , Tosetto Ilaria , Valenzise Mariella , Wasniewska Malgorzata , Maghnie Mohamad , Radetti Giorgio , Longhi Silvia , Betterle Corrado , Salerno Mariacarolina

Background: Primary Adrenal Insufficiency (PAI) is a rare life-threatening disorder. Data on etiology and outcome of PAI in childhood are scanty, with the exception of Congenital Adrenal Hyperplasia (CAH) due to 21-hydroxylase deficiency (21OHD). The aim of our study is to evaluate etiology, morbidity and long-term outcome of PAI in a large cohort of children and characterize clinical presentation in subjects with PAI not due to 21OHD CAH.Material and me...

ea0063gp188 | Adrenal and Neuroendocrine - Clinical | ECE2019

Increased risk of infections in Addison’s disease and congenital adrenal hyperplasia patients: a longitudinal study based on a United Kingdom primary care database

Tresoldi Alberto S , Sumilo Dana , Perrins Mary , Toulis Konstantinos A , Prete Alessandro , Reddy Narendra , Wass John A , Nirantharakumar Krishnarajah , Arlt Wiebke

Background: Primary adrenal insufficiency (PAI) can be of autoimmune origin (Addison’s disease, AD) or due to inborn disorders of steroidogenesis (congenital adrenal hyperplasia, CAH). Prognosis of patients with PAI has improved considerably after glucocorticoid replacement therapy became available. However, even in recent years, an increased risk of death has been described in both AD and CAH patients. Moreover, even with the current state-of-the-art replacement therapy,...

ea0063gp189 | Adrenal and Neuroendocrine - Clinical | ECE2019

Plasma renin concentration is associated with cardiac function and morphology in primary adrenal insufficiency

Wolf Peter , Beiglbock Hannes , Fellinger Paul , Pfleger Lorenz , Aschauer Stefan , Gessl Alois , Trattnig Siegfried , Kautzky-Willer Alexandra , Luger Anton , Winhofer Yvonne , Krssak Martin , Krebs Michael

Background: Despite adequate glucocorticoid (GC) and mineralocorticoid (MC) replacement therapy, primary adrenal insufficiency (AI) is associated with an increased mortality, mainly due to cardiovascular disease. The role of MC replacement is not known. Therefore we assessed whether renin concentrations during routine GC and MC substitution therapy are associated with cardiac function and morphology.Methods: 17 patients with AI underwent magnetic resonan...

ea0063gp190 | Adrenal and Neuroendocrine - Clinical | ECE2019

Management and outcome of pregnancies in women with adrenal insufficiency: experience from a retrospective European study

Bothou Christina , Anand Gurpreet , Kienitz Tina , Seejore Khyatisha , Simeoli Chiara , Ward Emma G , Paragliola Rosa Maria , Ferrigno Rosario , Badenhoop Klaus , Bensing Sophie , Oksnes Marianne , Drake William , Wahlberg Jeanette , Reisch Nicole , Hahner Stefanie , Pearce Simon , Trainer Peter , Etzrodt-Walter Gwendolin , Thalmann Sebastien P , Saevik AEse B , Husebye Eystein , Isidori Andrea M , Falhammar Henrik , Meyer Gesine , Corsello Salvatore M , Pivonello Rosario , Murray Robert , Quinkler Marcus , Beuschlein Felix

Background and aims: Recommendations for the management of pregnancies in patients with adrenal insufficiency (AI) are scarce. The aim of this study was to analyse current clinical approaches in seventeen specialized centers across Europe with a particular focus on maternal and fetal outcome.Patients: 95 pregnancies in 86 patients with AI of different aetiology [Addison’s disease (n=37), secondary AI (n=22), congenital adrenal hype...

ea0063gp191 | Adrenal and Neuroendocrine - Clinical | ECE2019

Pneumocystis pneumonia as a major complication of medical treatment for severe Cushing’s syndrome linked either to ectopic ACTH secretion or to Cushing’s disease

Cristante Justine , Mallaret Michel , Tourvieilhe Laura , Carreau Agnes , Vaillant Tiphaine , Yoldjian Isabelle , Chabre Olivier

Several cases of pneumocystosis developing after lowering cortisol serum level have been reported, mostly in patients with ectopic Cushing’s syndrome. We report here 2 cases of pneumocystosis which developed after initiation of treatment with metyrapone, one in a patient with Cushing’s disease, and the second in a patient with ectopic ACTH secretion by a prostate endocrine carcinoma. Both cases presented severe Cushing’s syndrome. We then analyzed the periodic s...

ea0063gp192 | Adrenal and Neuroendocrine - Clinical | ECE2019

Diagnostic accuracy of captopril challenge test and saline infusion test in patients at high risk for primary aldosteronism

Ceccato Filippo , Barbot Mattia , Sabbadin Chiara , Lolli Jacopo , Antonelli Giorgia , Plebani Mario , Boscaro Marco , Scaroni Carla

Background and aim: Aldosterone-to-Renin Ratio (ARR) is recommended as initial test to screen for Primary Aldosteronism (PA), especially in high-risk hypertensive population. Endocrine Society (ES) Guidelines recommend that patients with an increased ARR should undergo one or more confirmatory tests in order to confirm or exclude PA diagnosis. Captopril Challenge Test (CCT) and Saline Infusion Test (SIT) are commonly used in routine clinical practice. The aim of our study was ...

ea0063gp193 | Adrenal and Neuroendocrine - Clinical | ECE2019

Comparison of whole-genome expression analysis in patients with secondary adrenal insufficiency treated with conventional treatment versus modified-release hydrocortisone

Pilli Tania , Cardinale Sandro , Forleo Raffaella , Cantara Silvia , Ferracin Manuela , Bassi Cristian , Negrini Massimo , Grazia Castagna Maria

Background: Conventional treatment (cortisone acetate or hydrocortisone) of adrenal insufficiency (AI) is potentially associated with glycometabolic alterations, bone loss and reduced quality of life. There is an increasing evidence of a more physiological replacement therapy with modified-release hydrocortisone (Plenadren).AimThe objectives of our study were: 1) to compare the gene expression profile of patients under conventional treatment and Plenadren versus healthy contro...

ea0063gp194 | Adrenal and Neuroendocrine - Clinical | ECE2019

New perioperative imaging techniques, immunohistochemistry and genetic analysis to investigate the suitability of laparoscopic partial adrenalectomy in primary aldosteronism

van de Wiel Elle , Kusters Benno , Veltien Andor , Mukai Kuniaki , Deinum Jaap , Langenhuijsen Johan

Introduction & Objectives: A laparoscopic radical adrenalectomy is the standard treatment option for unilateral primary aldosteronism. Partial adrenalectomy for solitary adenomas has been suggested to be feasible and adrenal cortex-sparing. However, solitary adenomas may be rare. The purpose of this study was to assess whether partial adrenalectomy in patients with a seemingly solitary adenoma might be worthwhile by relating perioperative imaging to pathologic findings of ...

ea0063gp195 | Adrenal and Neuroendocrine - Clinical | ECE2019

Evaluation of clinical and biochemical cure and adrenal CYP11B2 and CYP11B1 immunostaining in primary aldosteronism operated after adrenal venous sampling

Matikainen Niina , Nevalainen Pasi I , Soinio Minna , Gomez-Sanchez Celso , Vesterinen Tiina , Leijon Helena

Background: The cure of unilateral primary aldosteronism (PA) after adrenalectomy can result in complete, partial or absent biochemical and clinical improvement1. Histological findings from HE samples are of little assistance in determining if adenoma or hyperplastic adrenal tissue is hormonally overactive. Our aim in the present study was to compare immunohistochemical (IHC) CYP11B1 and CYP11B2 staining in adrenal slices to histological diagnosis based on H&E s...

ea0063gp196 | Adrenal and Neuroendocrine - Clinical | ECE2019

Sexual function in adrenal insufficiency: data from the DREAM trial

Hasenmajer Valeria , Sbardella Emilia , Pozza Carlotta , Simeoli Chiara , Mazzotta Paola , Lecis Claudio , Lenzi Andrea , Pivonello Rosario , Angelo Jannini Emmanuele , Gianfrilli Daniele , Marcello Isidori Andrea

Introduction: Adrenal Insufficiency (AI) is characterized by absolute or relative deficiency of glucocorticoids and adrenal androgen precursors. Patients with AI show an impaired quality of life, metabolic status, immune function and dysregulated circadian genes. Data on sexual function are scarce and often contradictory. The aims of the present study are to evaluate sexual dysfunction (SD) in women and men patients with AI and to investigate the effects of restoring a more ph...

ea0063gp197 | Adrenal and Neuroendocrine - Clinical | ECE2019

Optimizing mineralocorticoid replacement therapy in patients with congenital adrenal hyperplasia and Addison’s disease

Pofi Riccardo , Prete Alessandro , Thornton-Jones Vivien , Bryce Jilian , Ali Salma , Ahmed Faisal , Koehler Birgit , Balsamo Antonio , Acerini Carlo , Cannuccia Amalia , Guven Ayla , Guran Tulay , Darendeliler Feyza , Higham Claire , Bonfig Walter , De Vries Liat , Mendonca Berenice B , Iotova Violeta , Krone Nils P , Krone Ruth , Lenzi Andrea , Arlt Wiebke , Ross Richard , Isidori Andrea M , Tomlinson Jeremy W

Background: Adrenal insufficiency (AI) results from deficient production/action of glucocorticoids (GCs), with or without deficiency of mineralocorticoids (MC) and adrenal androgens. GC treatment is essential but some patient needs MC therapy to allow sodium(Na+) retention, potassium(K+) excretion and to maintain normal plasma volume and blood pressure. Much attention has focused on optimization of GC replacement but no consensus exists for optimization o...

ea0063gp198 | Adrenal and Neuroendocrine - Clinical | ECE2019

Analysis of circulating microRNAs in primary aldosteronism

Decmann Abel , Nyirő Gabor , Darvasi Otto , Turai Peter , Bancos Irina , Pezzani Raffaele , Kraljevic Ivana , Kastelan Darko , Parasiliti-Caprino Mirko , Nirschl Nina , Heinrich Daniel , Patocs Attila , Igaz Peter

Introduction: Primary aldosteronism (PA) is a major cause of secondary hypertension. The two major forms of sporadic PA (aldosterone producing adenoma – APA and bilateral adrenal hyperplasia – BAH) can only be reliably differentiated by adrenal venous sampling (AVS). Several mutations have been described for APA, but the pathogenesis of BAH is poorly elucidated. Differentiation of APA and BAH is clinically pivotal, as their treatment is different. There is no blood-b...

ea0063gp199 | Adrenal and Neuroendocrine - Clinical | ECE2019

LC-MS/MS measurement for urinary aldosterone improves primary aldosteronism screening

Travers Simon , Blanchard Anne , Cornu Erica , Faucard Catherine , Baffalie Laurence , Azizi Michel , Houillier Pascal , Amar Laurence , BARON Stephanie

Objective: Primary aldosteronism (PA) is the first cause of endocrine hypertension accounting for about 6% of all cases of hypertension. According to international guidelines, PA screening is based on plasma aldosterone-to-renin concentration ratio (ARR) computation. Nevertheless, measurement of urine aldosterone excretion may be of interest since it integrates aldosterone secretion over 24 hours. However, available urine aldosterone immuno-assays have poor specificity.<p ...