Benign Thyroid Disorders

ea0063gp176 | Benign Thyroid Disorders | ECE2019

Do different initial doses of L-T4 within the range of 10–15 mcg/kg/die influence neurodevelopment during the first two years of life in children with congenital hypothyroidism?

Moracas Cristina , Ciccarelli Gian Paolo , Bravaccio Carmela , Cassio Alessandra , Gastaldi Roberto , Mussa Alessandro , Polizzi Miriam , Vigone Maria Cristina , Wasniewska Malgorzata Gabriela , Weber Giovanna , Salerno Mariacarolina

Background: The initial L-T4 dose in the treatment of congenital hypothyroidism (CH) currently recommended is 1015 mcg/kg/die.Objective: We designed a multicenter randomized trial to evaluate the effects of different starting dose of L-T4 within the range 1015 mcg/kg/die on neurocognitive development in children with CH.Methods: Seventy-two children with CH diagnosed by neonatal screening were enrolled in the study. The...

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ea0063gp177 | Benign Thyroid Disorders | ECE2019

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ea0063gp178 | Benign Thyroid Disorders | ECE2019

Cystic fibrosis as a novel cause of thyroxine (l-t4) malabsorption and increased requirement

Giuffrida Giuseppe , Magazzu Giuseppe , Campenni Alfredo , Lucanto Maria Cristina , Trimarchi Francesco , Cannavo Salvatore , Ruggeri Rosaria Maddalena

Background: Cystic fibrosis (CF), a monogenic disease from mutations in the CFTR gene on chromosome 7, causes pancreatic insufficiency and impaired nutrients absorption. Unlike other malabsorption disorders, no data are available in literature on L-T4 absorption in CF. This study analyzed L-T4 absorption and requirement in hypothyroid CF patients.Methods: Ten CF patients (7 F, 3 M; mean age 37 yr), with autoimmune (n=6) or post-thyroidectomy (<e...

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ea0063gp179 | Benign Thyroid Disorders | ECE2019

Long-term cardiometabolic effects of maternal sub-optimal gestational thyroid function and relative treatment in the Controlled Antenatal Thyroid Screening (CATS) study II

Muller Ilaria , Taylor Peter , Daniel Rhian , Hales Charlotte , Scholz Anna , Yin Xiaochen , Candler Toby , Pettit Rebecca , Evans William , Shillabeer Dionne , Draman Mohd , Dayan Colin , Tang Carolyn , Okosieme Onyebuchi , Gregory John , Lazarus John , Rees Aled , Ludgate Marian

Introduction: The effects of maternal suboptimal gestational thyroid function (SGTF) on age 3 offsprings cognitive function were investigated in the Controlled Antenatal Thyroid Screening (CATS) randomised trial, comparing SGTF mothers who received (SGTF-T), or didnt (SGTF-U), levothyroxine during pregnancy. The analysis was repeated at age 9 in the CATS-II follow-up study, also including children of mothers with normal gestational thyroid function (NGTF). Here we ...

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ea0063gp180 | Benign Thyroid Disorders | ECE2019

Urinary concentration of iodotyrosines correlates with the severity of iodine deficiency in dehal1 knockout mice

Gonzalez-Guerrero Cristian , Borso Marco , Garcia-Gimenez Jorge , Salas-Lucia Federico , Alikhani Pouya , Saba Alessandro , Zucchi Riccardo , Moreno Jose C

Thyroid hormone (TH) synthesis requires iodine, a scarce element whose recycling is mediated by DEHAL1 through deiodination of iodotyrosines MIT and DIT. In humans, DEHAL1 defects lead to severe congenital hypothyroidism (CH) non-detected by neonatal screening programs, which involves the risk of mental retardation in infants. The timing for establishment of this hypothyroidism remains unknown, but environmental iodine deficiency may represent a triggering factor. Whi...

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ea0063gp181 | Benign Thyroid Disorders | ECE2019

Effect of anti-streptavidin interference when diagnosing thyroid disease using immunoassay analyses

Dahll Louise K , Haave Ellen M , Aas Finn Erik , Dahl Sandra R , Thorsby Per M

Background: The purpose of this study was to register the frequency and cause of method-dependent interference in the Roche thyroid immunoassays observed in our laboratory.Methods: Serum samples to confirm discordant thyroid results were collected from June 2013 to September 2018, in samples sent to the Hormone Laboratory, Oslo University Hospital. The laboratory serves as a reference laboratory on thyroid diseases for about 2/3 of the inhabitants of Nor...

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ea0063gp182 | Benign Thyroid Disorders | ECE2019

Can hepcidin be a useful marker in the diagnosis and monitoring of de Quervain thyroiditis?

Filipowicz Dorota , Hernik Aleksandra , Szczepanek-Parulska Ewelina , Ruchała Marek

Introduction: Hepcidin is a reactive inflammatory protein, responsible for ferrum homeostasis. Its concentration was already measured in hyperthyroiditis in the course of Graves disease and after restoration of euthyroidism, but also in growth hormone deficiency, hyperprolactinemia, however no significant changes were noted. De Quervain thyroiditis is a rare type of subacute thyroid inflammation, caused by interplay of unknown infectious, genetic and autoimmune factors and res...

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ea0063gp183 | Benign Thyroid Disorders | ECE2019

High-dose intravenous levothyroxine treatment as a successful, safe and clinically effective therapy option in severe hypothyroidism: a retrospective study

Aznar Pablo Trincado , Garcia Maria Martinez , Sanchez Beatriz Lardies , Alaminos Maria Elena Lopez , Fernandez Mikel Gonzalez , Rosas Karol Almendra Alvarado , Lacleta Isabel Melchor , Perez Javier Acha

Introduction: Treatment of hypothyroidism with levothyroxine is effective and simple; however, international guidelines advise starting with low doses in case of severe hypothyroidism, cardiac illness and aged population. Interestingly, and in contradiction to this dogma, high doses of levothyroxine have been given to patients with myxedema coma without untoward effects. The difference between myxedema coma, which deserves an intensive treatment, and longstanding severe hypoth...

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ea0063gp184 | Benign Thyroid Disorders | ECE2019

Effect of restoration of thyroid function on body composition, insulin resistance and visfatin concentrations in women with hypo- and hyperthyroidism

Sawicka-Gutaj Nadia , Zybek-Kocik Ariadna , Kloska Michal , Czarnywojtek Agata , Sowiński Jerzy , Mańkowska-Wierzbicka Dorota , Ruchała Marek

Introduction: The adipose tissue secrets visfatin, that might have metabolic effect. Changes of visfatin serum concentrations have been observed in different thyroid pathologies. Thyroid hormones affect metabolism, thus, both hypo- and hyperthyroidism might significantly alter body composition.Aims of the study: We aimed to investigate the effect of restoration of euthyroidism on serum visfatin in severe thyroid dysfunction, and its associations with ins...

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ea0063gp185 | Benign Thyroid Disorders | ECE2019

Thyroid-related adverse events in patients treated with Nivolumab and Pembrolizumab

Sbardella Emilia , Tenuta Marta , Sirgiovanni Grazia , Pozza Carlotta , Gianfrilli Daniele , Mazzotta Paola , Pandozzi Carla , Cortesi Enrico , Lenzi Andrea , Gelibter Alain J , Isidori Andrea M

Introduction: Immune-Checkpoint Inhibitors (ICI) are frequently associated with thyroid-related adverse events (AE). Several studies analyzed thyroid disfunctions during ICI therapy, but many aspects remain to be characterized, especially for the most recent anti-PD-1 drugs. The aim of this study is to determine incidence and characteristics of PD-1 inhibitors associated thyroid dysfunction.Methods: We retrospectively analyzed data of patients with advan...

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ea0063gp186 | Benign Thyroid Disorders | ECE2019

Metformin reduces risk of benign nodular goiter in patients with type 2 diabetes mellitus

Tseng Chin-Hsiao

Background: Whether metformin might affect the risk of benign nodular goiter in patients with type 2 diabetes mellitus has not been investigated.Methods: Patients with new-onset type 2 diabetes mellitus during 1999-2005 were enrolled from Taiwans National Health Insurance database. Analyses were conducted in a propensity score matched-pairs of 20,048 ever users and 20,048 never users of metformin. The patients were followed until December 31, 2011 ...

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Endocrine Abstracts

21st European Congress of Endocrinology

Guided Posters

Do different initial doses of L-T4 within the range of 10–15 mcg/kg/die influence neurodevelopment during the first two years of life in children with congenital hypothyroidism?

Cystic fibrosis as a novel cause of thyroxine (l-t4) malabsorption and increased requirement

Long-term cardiometabolic effects of maternal sub-optimal gestational thyroid function and relative treatment in the Controlled Antenatal Thyroid Screening (CATS) study II

Urinary concentration of iodotyrosines correlates with the severity of iodine deficiency in dehal1 knockout mice

Effect of anti-streptavidin interference when diagnosing thyroid disease using immunoassay analyses

Can hepcidin be a useful marker in the diagnosis and monitoring of de Quervain thyroiditis?

High-dose intravenous levothyroxine treatment as a successful, safe and clinically effective therapy option in severe hypothyroidism: a retrospective study

Effect of restoration of thyroid function on body composition, insulin resistance and visfatin concentrations in women with hypo- and hyperthyroidism

Thyroid-related adverse events in patients treated with Nivolumab and Pembrolizumab

Metformin reduces risk of benign nodular goiter in patients with type 2 diabetes mellitus

BiosciAbstracts