Searchable abstracts of presentations at key conferences in endocrinology

ea0081p277 | Adrenal and Cardiovascular Endocrinology | ECE2022

Presenting clinical features of Cushing’s syndrome and non-classic hypercortisolism

Delle Donne Elisa , Parazzoli Chiara , Favero Vittoria , Chiodini Iacopo , Morelli Valentina , Aresta Carmen

Background: The Endocrine Society Guidelines recommend screening for hypercortisolism especially in patients with specific features that best discriminate CushingÂ’s Syndrome (CS): easy bruising, facial plethora, proximal myopathy and striae. Clinical experience suggests that these features, though suggestive of hypercortisolism, are not enough sensitive. Indeed, patients with hypercortisolism frequently manifest primarily less discriminatory cortisol-related features, suc...

ea0081p689 | Pituitary and Neuroendocrinology | ECE2022

Peculiar presentation of a TSH-secreting pituitary adenoma: a possible new multiple endocrine syndrome?

Goggi Giovanni , Campi Irene , Delle Donne Elisa , Moro Mirella , Guizzardi Fabiana , Bonomi Marco , Persani Luca

Introduction: TSH-secreting pituitary adenomas (TSHomas) are a rare cause of central hyperthyroidism, accounting for less than 1% of all pituitary adenomas, with a prevalence in the general population of 1-2 cases per million.Case Presentation: A 45-year-old female patient presented in 2009 with hypertension and tachycardia: blood tests revealed an inappropriately normal TSH with high fT3/fT4 levels and primary hyperaldosteronism. She declined further in...

ea0090p546 | Late-Breaking | ECE2023

Polycythemia vera and feminizing hormone treatment in an individual Assigned Male at Birth (AMAB): a prickly situation

Parazzoli Chiara , Delle Donne Elisa , Federici Silvia , Amer Myriam , Persani Luca , Bonomi Marco , Bonadonna Stefania

Introduction: Feminizing hormone therapy (HT) for male-assigned at birth (AMAB) includes estrogens, often in combination with anti-androgens. Several studies have reported an increased incidence of cardiovascular diseases and venous thromboembolism in AMAB receiving estrogens. Indeed, procoagulant changes induced by estrogen-based HT occur in transwomen as well as in cisgender individuals. Therefore, using estrogen in gender-affirming HT is relatively contraindicated in those ...

ea0090p270 | Late-Breaking | ECE2023

Monitoring serum estradiol levels in clinical practice: a retrospective study in transgender AMAB subjects

Federici Silvia , Garofalo Chiara , Parazzoli Chiara , Amer Myriam , Delle Donne Elisa , Persani Luca , Bonadonna Stefania , Bonomi Marco

The Standards of Care version 8 (SOC 8) for transgender and gender diverse people suggest maintaining estradiol (E2) levels between 100-200 pg/ml in Assigned Male at Birth (AMAB) subjects who desire a complete feminization during gender affirmation hormone therapy (GAHT). However, data about estrogen dose therapy and corresponding serum concentrations are scarce, especially regarding gel formulations. Our aim was to retrospectively compare E2 serum levels in AMAB patients unde...