Searchable abstracts of presentations at key conferences in endocrinology

ea0090rc6.6 | Rapid Communications 6: Endocrine-related Cancer | ECE2023

C-peptide level concomitant with hypoglycemia gives better performances than insulin for the diagnosis of endogenous hyperinsulinism: a monocentric study of 159 fasting trials

Fideline Bonnet , Devin Clara , Thomeret Louis , Laguillier-Morizot Christelle , Leguy Marie-Clemence , Vaczlavik Anna , Bouys Lucas , Zientek Corinne , Bricaire Leopoldine , Bessiene Laura , Guignat Laurence , Libe Rossella , Mosnier-Pudar Helen , Assie Guillaume , Groussin Lionel , Guibourdenche Jean , Bertherat Jerome

Introduction: The gold standard for insulinoma diagnosis is still 72-hours fasting trial with the aim to trigger WhippleÂ’s triad. In this context, biological diagnosis of endogenous hyperinsulinism relies on the occurrence of a hypoglycemia, concomitant with inadequate high insulin and C-peptide levels. However, diagnostic cut-offs are not consensual among the different learned societies (Endocrine Society 2009, NANETS 2010, ENETS 2012). The objective of this wor...