Searchable abstracts of presentations at key conferences in endocrinology

ea0038p207 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Adrenaline mediated metabolic and functional quiescence protects insulin producing cells from hypoxia

Kelly Amy , Smith Rachel , DiBase Samantha , Davenport Hailey , Limesand Sean

Pancreatic islets are susceptible to hypoxia during isolation, culture, and transplantation. An intervention that protects against hypoxia while preserving β-cell function will improve islet quality. Adrenaline suppresses insulin secretion and oxygen consumption in pancreatic islets. These findings suggest that adrenergic action creates metabolic quiescence in β-cells. Our objective was to determine whether adrenaline is protective during hypoxic culture in an insuli...