ea0035p341 | Diabetes (epidemiology, pathophysiology) | ECE2014
Carlessi Rodrigo
, Dias Ana Luiza
, Bauer Andrea
, Canani Luis Henrique
, Leitao Cristiane
, Crispim Daisy
Introduction: Pancreatic islet transplantation is an attractive approach to re-establish glycemic homeostasis in patients with brittle type 1 diabetes. However, islet damage along the isolation procedure limits the availability of viable islets for transplantation. The donors brain death (BD) is among the factors contributing for islet quality loss in this scenario. Exenatide, a glucagon-like peptide-1 (GLP1) analog, exerts anti-inflammatory effects leading to an increas...