Searchable abstracts of presentations at key conferences in endocrinology

ea0035p341 | Diabetes (epidemiology, pathophysiology) | ECE2014

Exenatide protects pancreatic islets against brain death-induced inflammation and viability loss

Carlessi Rodrigo , Dias Ana Luiza , Bauer Andrea , Canani Luis Henrique , Leitao Cristiane , Crispim Daisy

Introduction: Pancreatic islet transplantation is an attractive approach to re-establish glycemic homeostasis in patients with brittle type 1 diabetes. However, islet damage along the isolation procedure limits the availability of viable islets for transplantation. The donor’s brain death (BD) is among the factors contributing for islet quality loss in this scenario. Exenatide, a glucagon-like peptide-1 (GLP1) analog, exerts anti-inflammatory effects leading to an increas...