Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep274 | Calcium & Vitamin D metabolism | ECE2017

Calcifediol is more effective than cholecalciferol in the treatment of severe vitamin D deficiency in a patient submitted to malabsorbitive bariatric surgery: a case report

Brancatella Alessandro , Cappellani Daniele , Vignali Edda , Canale Domenico , Marcocci Claudio

Context: Vitamin D deficiency following malabsorptive bariatric surgery can lead to osteomalacia. We report a patient with severe vitamin D deficiency following malabsorptive bariatric surgery successfully treated with calcifediol but not cholecalciferol.Case description: A 40-year-old woman, submitted to biliopancreatic diversion 20 years before and chronically treated with 50 000 IU cholecalciferol weekly, was admitted to our Endocrine Unit because of ...

ea0014p626 | (1) | ECE2007

Androgenicity, androgen receptor polymorphism and pharmacogenetics

Canale Domenico , Moschini Cecilia , Caglieresi Carolina , Moscatelli Agnese , Gavioli Silvia , Macchia Enrico , Martino Enio

Exon 1 of the androgen receptor (AR) gene contains a variable number of CAG triplets, (CAGr)n which encode a polyglutamine stretch of variable length in the N-terminal domain of the receptor. Experimental evidence has accumulated in demonstrating that the length of this stretch influences the transcriptional activity induced by the AR and therefore modulates target organs responsiveness to androgens.The (CAGr)n is inversely associated with the transcript...