Searchable abstracts of presentations at key conferences in endocrinology

ea0037gp.26.03 | Thyroid – hypothyroidism | ECE2015

Adverse metabolic correlations relate to free T3 levels in subclinical hypothyroidism; common FOXE1 polymorphisms associate with blood pressure

de Lloyd Anna , Muller Ilaria , Dodd Alan , Bakhsh Ameen , Durrant Hilary , Zhang Lei , Evans Carol , Rees Aled , Ludgate Marian

Introduction: The effects of mild subclinical hypothyroidism (SH; TSH <10 mU/l) on metabolic outcomes are unclear. This may relate to differences in aetiology, including thyroid autoimmunity or genetic factors such as TSH-receptor mutations (TSHR-M) and FOXE1 polyalanine tract length (FOXE1–PTL) polymorphisms, which are associated with altered thyroid function. We hypothesised that the metabolic manifestations of SH may depend upon its aetiology.<p class="abstext"...

ea0037ep253 | Calcium and Vitamin D metabolism | ECE2015

TSH and free-T3 correlate negatively and independently with bone mineral density in adults with subclinical hypothyroidism

de Lloyd Anna , Muller Ilaria , Dodd Alan , Durrant Hilary , Pettit Rebecca , Darlington Sarah , Zhang Lei , Evans Carol , Rees Aled , Ludgate Marian

The role of the thyrotropin receptor (TSHR) in bone is unclear. TSHR-deficient mice have low bone mineral density (BMD) and focal osteosclerosis despite normal thyroid hormones (suggesting TSHR function, in bone, is important). Subclinical hypothyroidism (SH) has various aetiologies including thyroid autoimmunity (TA) and inactivating TSHR mutations (TSHR-M). In TSHR-deficiency & TSH-M elevated TSH compensates for reduced TSHR function, whereas in TA it compensates for red...