ea0081p79 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022
Joshi Shruti
, Singh Trisha
, Kershaw Lucy
, Gibb Fraser
, Dweck Marc R
, Williams Michelle
, Semple Scott
, Forbes Shareen
, Reynolds Rebecca
, Newby David
Background and Aims: Type 1 diabetes mellitus (T1DM) is characterised by autoimmune destruction of pancreatic beta-cells resulting in insulin deficiency. Evaluation of novel therapies for T1DM requires reliable methods to measure beta-cell function, which is unattainable using traditional non-invasive imaging techniques. A new approach is manganese-enhanced magnetic resonance imaging (MEMRI). As a calcium analogue, manganese is taken up into pancreatic beta-cells during insuli...