Endocrine Abstracts

Ojective: We characterized the onset and follow-up of hypophysitis in a cohort of 612 patients treated for a cancer by antitumoral immunotherapy between june 2010 and may 2017 in CHU Lille, France. Design and patients: 612 patients treated by anti-CTLA4 and or antiPD-1 for melanoma (n=426), lung cancer (n=166), hematological cancer (n=19) or maxillary epidermoid cancer (n=1).Methods: Follow-up of patients treated by im...

The aim of this retrospective study was to compare the long-term metabolic evolution of a cohort of patients treated for adrenal insufficiency (AI), and the best biological parameters of a good balance.Seventy patients with AI (mean age 41 years (±16); 60% female) were followed during a median 6-year period (2–16 years): 38 after bilateral adrenalectomy (60% Cushing) and 32 after AI of medical origin (62% polyglandular autoimmune syndrome). BMI...

Introduction: Guidelines recommend using first-line tests, including 24-hour urine-free cortisol (UFC), overnight 1-mg dexamethasone suppression test (DST), and late-night salivary cortisol (LNSC) for the positive diagnosis of hypercortisolism. Unfortunately, LNSC access is constrained in certain institutions, requiring, as an alternative, hospitalization for midnight plasmatic cortisol (F00h) measurement. This study explores the diagnostic potential of afternoon plasma cortis...

Introduction: Few studies to date have attempted to evaluate the early efficacy of first-generation somatostatin analogs in somatotroph macroadenomas.Objective: To investigate the short-term efficacy of primary therapy with lanreotide 120 mg on tumor shrinkage and ophthalmologic symptoms in newly diagnosed patients with acromegaly.Design and patients: This single-center retrospective study included 21 patients who were newly diagno...