Endocrine Abstracts

Immune-checkpoint inhibitors have become important elements of oncology therapy in recent years. These monoclonal antibodies block immune-checkpoints, unleashing T cells to fight cancer. However, immune-checkpoints also play an important role in the prevention of autoimmune processes and immune-checkpoint inhibitor therapy can also trigger autoimmune adverse effects, termed immune-related adverse events. Endocrinopathies are among the most common immune-related side effects.</...

Introduction: In acromegaly GH excess leads to impaired insulin sensitivity with an alteration of beta-cell function. The consequent hyperglycemia leads to a further increased cardiovascular risk and mortality.Case report: A 16 years old patient was first referred to the Department of Pediatrics in 2014 with accentuated growth since the age of 10. The reason of the first referral was a sport injury (head trauma during playing basketball). Sella MRI depic...