Searchable abstracts of presentations at key conferences in endocrinology

ea0056p377 | Diabetes (to include epidemiology, pathophysiology) | ECE2018

TWEAK levels in patients with prediabetes and diabetes mellitus

Okuturlar Yildiz , Kocoglu Hakan , Serin Sibel Ocak , Ercan Tarik , Hursitoglu Mehmet , Mert Meral , Ozdemir Bahar , Erismis Betul , Gedikbasi Asuman , Harmankaya Ozlem

Introduction: Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) belongs to TNF family and is released from inflammatory cells. It has been reported that TWEAK has several biological actions ranging from cell proliferation to stimulation of apoptosis. In in vitro studies, it was reported that TWEAK has alleviating effect on insulin resistance in hepatocytes. TWEAK decreases insulin resistance induced by TNF-a through activation of phosphatase 2A pathway in a...