Endocrine Abstracts

Dysregulation of the neuroendocrine system is a key element in the pathogenesis of polycystic ovary syndrome (PCOS). Orexins (hypocretins) are a new class of hypothalamic neuropeptides that influence sleep-wake rhythms and the state of energy metabolism. In addition, their receptors expresses in peripheral tissues, including the endocrine system. Data have emerged on the role of orexins in the regulation of the reproductive system and, in particular, ovulation, through a direc...