Searchable abstracts of presentations at key conferences in endocrinology

ea0056nsa2 | (1) | ECE2018

A comprehensive map of splicing alterations in small cell lung cancer

Eyras Eduardo

Small cell lung cancer (SCLC) is the most aggressive form of lung cancer as it lacks known targets of therapy. 5-year survival is only 5% and patients quickly develop therapy resistance by yet unknown mechanisms. The lack of advances is also related to the fact that SCLC is not part of the ICGC or TCGA cancer genomics projects, and patient material is hard to obtain. SCLC presents frequent amplifications in genes of the MYC family, which are known regulators of splicing factor...

ea0099p507 | Endocrine-Related Cancer | ECE2024

SRSF6 modulates histone-chaperone HIRA splicing to orchestrate androgen and E2F signalling in prostate cancer

Montero-Hidalgo Antonio J , Vacas Juan Manuel Jimenez , Gomez-Gomez Enrique , Blazquez-Encinas Ricardo , Sanchez-Sanchez Rafael , Martinez-Fuentes Antonio Jesus , Eyras Eduardo , Castano Justo P , Sharp Adam , Olmos David , Gahete Manuel D , Luque Raul M

Prostate cancer (PCa) is one of the most common endocrine-related cancers (ERCs) among men worldwide. The aggressiveness of this tumor pathology is highly influenced by different endocrine-related factors, highlighting the crucial role of androgens. Therefore, the main therapeutic approach for PCa patients is based on the pharmacological blockade of androgen-signaling. However, some patients become unresponsive and develop a highly lethal castration-resistant disease, pointing...