Endocrine Abstracts

Small cell lung cancer (SCLC) is the most aggressive form of lung cancer as it lacks known targets of therapy. 5-year survival is only 5% and patients quickly develop therapy resistance by yet unknown mechanisms. The lack of advances is also related to the fact that SCLC is not part of the ICGC or TCGA cancer genomics projects, and patient material is hard to obtain. SCLC presents frequent amplifications in genes of the MYC family, which are known regulators of splicing factor...

Prostate cancer (PCa) is one of the most common endocrine-related cancers (ERCs) among men worldwide. The aggressiveness of this tumor pathology is highly influenced by different endocrine-related factors, highlighting the crucial role of androgens. Therefore, the main therapeutic approach for PCa patients is based on the pharmacological blockade of androgen-signaling. However, some patients become unresponsive and develop a highly lethal castration-resistant disease, pointing...