Searchable abstracts of presentations at key conferences in endocrinology

ea0011p25 | Bone | ECE2006

Effects of growth hormone administration on parathyroid hormone sensitivity and bone mineral metabolism in established osteoporosis

Joseph F , Ahmad A , White HD , Joshi A , Durham B , Vinjamuri S , Ashawesh K , Fraser WD , Vora JP

Introduction: The beneficial effect of GH replacement on bone in AGHD patients is mediated by improvements in target organ sensitivity to PTH and phosphocalcium metabolism. In aging women with established osteoporosis, GH and IGF-1 concentrations are lower and administration of GH has been shown to increase bone turnover and BMD, but the mechanisms remain unclear.Methods: Fourteen postmenopausal women (63.4±2.1 years; mean BMD T score ± ...

ea0007p2 | Bone | BES2004

Does leptin regulate bone turnover in adult growth hormone deficiency?

Joseph F , Ahmad A , Wallace A , White H , Durham B , Fraser W , Vora J

Leptin stimulates osteoblastic cell proliferation, differentiation and mineralisation and inhibits osteoclast generation; leptin secretion and bone turnover are altered in adult growth hormone deficiency, a condition associated with osteoporosis. The aim of this study was to investigate leptin circadian rhythm and its association with bone turnover in untreated AGHD and following growth hormone replacement (GHR).We sampled peripheral venous blood at half...

ea0007p25 | Cytokines and growth factors | BES2004

Effects of long term growth hormone replacement on leptin and body composition in adult growth hormone deficiency

Joseph F , Ahmad A , Wallace A , White H , Durham B , Fraser W , Vora J

Growth hormone (GH) and leptin regulate body composition and leptin is elevated in adult growth hormone deficiency (AGHD), a syndrome characterised by increased adiposity. We have previously shown that GH replacement for 1 month reduces 24-h mean leptin concentration independent of changes in fat mass. The long tem effects of GHR on leptin have not been described.24-h mean total leptin concentration was measured using half-hourly blood sampling, to accou...

ea0063p124 | Diabetes, Obesity and Metabolism 1 | ECE2019

Management of acute charcot arthropathy

Ahmad F , Yehia S , Devaka F , Muraleedharan V , Sihota S , Abdulla H , Higgins E , Fisher A , Thompson J

Aims/objectives: The aim of this retrospective audit on MANAGEMENT OF ACUTE CHARCOT ARTHROPATHY was to assess the current practice at King’s Mill hospital against the latest National institute of clinical excellence guidelines.Methods: A retrospective audit of 22 patients with diabetes presented with acute Charcot neuro-arthropathy, between January 2016 and August 2018 to the specialist diabetes foot team at KMH. The data was collected from the hosp...