Endocrine Abstracts

The overall incidence of carcinoid tumors has been estimated to be 1 to 2 cases /100000 people in USA. Carcinoid tumors habitually accounts for 1% of all cases of Cushing’s syndrome. The authors report an unusual case of ectopic secretion of corticotropin from pulmonary carcinoid tumor.A. F. is a 29 years old patient who has been referred for hypercorticism with patent features including trophical signs and severe depression.L...

The insulin-like growth factor binding proteins (IGFBPs-1 to -6) complex IGF-I and -II and were originally assumed to limit IGF access to the main IGF signalling receptor (IGFR) and decrease IGF activity. IGFBP-5 is the most conserved of the IGFBPs. Examination of its primary sequence reveals that, in addition to the key IGF binding domain, additional functional motifs are present that are not related to its IGF binding function.IGFBP-5 is upregulated du...

The insulin-like growth factor binding proteins (IGFBPs-1 to -6) complex IGF-I and -II and were originally assumed to limit IGF access to the main IGF signalling receptor (IGFR) and decrease IGF activity. IGFBP-5 is the most conserved of the IGFBPs. Examination of its primary sequence reveals that, in addition to the key IGF binding domain, additional functional motifs are present that are not related to its IGF binding function.IGFBP-5 is upregulated du...

IntroductionThyrotoxic periodic paralysis (TPP) is a rare complication of hyperthyroidism characterized by the sudden onset of hypokalemia and muscle paralysis. This rare but possible clinical presentation of thyrotoxicosis is significantly more predominant in males of asian descent. The mechanisms of hypokalemia are incompletely understood. The prevailing theories include increased Na-K ATPase pump activity and mutations in genes encoding Kir channels i...

The androgen receptor (AR) plays a pivotal role in prostate cancer development, progression and hormone-therapy resistant disease. AR requires a permissive epigenetic state at distinct chromatin regions to facilitate gene expression programs. The vast majority of AR sites are found at active enhancer regions, hallmarked by histone modification H3K27Ac and devoid of repressive markers including H3K27me3. In search for novel biomarkers for prostate cancer prognostication, we per...

Background: Venous thromboembolism(VTE) is a well-known perioperative complication in patients with Cushing’s syndrome(CS) and may be preventable. A recent report highlighted that thromboprophylaxis management in patients with CS still varies considerably across Endo-ERN reference centers but the actual incidence of VTE and its management in individual patients is unclear.Aim: To collect epidemiological and clinical data of new cases of CS reported ...