Searchable abstracts of presentations at key conferences in endocrinology

ea0022p476 | Female reproduction | ECE2010

Structured exercise training plus hypocaloric diet improves ovarian sensitivity to clomiphene citrate in polycystic ovary syndrome (PCOS) patients

Palomba Stefano , Giallauria Francesco , Falbo Angela , Russo Tiziana , Grieco Alessandra , Colao Annamaria , Lombardi Gaetano , Orio Francesco

Clomiphene citrate (CC) is the first-line therapy for inducing ovulation in infertile women with polycystic ovary syndrome (PCOS), but about 20% of them results un-responsive. Lifestyle modification programs are effective in restoring ovarian function and improving reproductive outcomes in PCOS patients.The aim of the present randomized controlled trial was to test the hypothesis that a very short-term intervention consisting in structured exercise train...

ea0063p644 | Interdisciplinary Endocrinology 1 | ECE2019

Dominance of ovarian follicles is determined by follicle-stimulating hormone receptor (FSHR) and G protein-coupled estrogen receptor (GPER) heteromers

Casarini Livio , Lazzaretti Clara , Paradiso Elia , Riccetti Laura , Sperduti Samantha , Marcozzi Serena , Sayers Niamh , Brigante Giulia , Poti Francesco , La Marca Antonio , Valli Barbara , Falbo Angela , Villani Maria Teresa , Klinger Francesca Gioia , Fane Francesca , Hanyaloglu Aylin Carla , Simoni Manuela

Mechanisms regulating the selection of antral ovarian follicles are poorly understood and supposed to rely on low estrogen levels, decline of follicle-stimulating hormone (FSH) levels and receptor (FSHR) expression on the surface of granulosa cells. These concepts are challenged in-vitro, where apoptosis of human granulosa cells (hGLC) and transfected cell lines is induced by high doses of FSH or FSHR overexpression, while estrogens induce anti-apoptotic signals via n...