Searchable abstracts of presentations at key conferences in endocrinology

ea0028oc2.6 | Reproduction and bone | SFEBES2012

Identification of microRNAs involved in regulating growth factor signalling in the first trimester placenta

Farrokhnia Farkhondeh , Westwood Melissa , Aplin John , Forbes Karen

Fetal growth restriction and overgrowth (macrosomia) are both associated with altered placental development and problems at birth. Both conditions have lifelong impacts on health including an increased risk of developing cardiovascular disease and diabetes. Placental development depends on co-ordinated cellular growth and is enhanced by maternally-derived growth factors. MicroRNAs (miRs) are known to regulate gene expression and we have shown that global miR suppression in pla...