Searchable abstracts of presentations at key conferences in endocrinology

ea0099oc1.1 | Oral Communications 1: Reproductive and Developmental Endocrinology | ECE2024

Hypospadias is linked to genetic susceptibility to the environment through oncogenes and its incidence is geographically correlated to that of cancers worldwide

Kalfa Nicolas , Bergougnoux Anne , Philibert Pascal , Servant Fauconnet Nadege , Faure Alice , Breaud Jean , Gaspari Laura , Sultan Charles , Paris Francoise

Background: The etiology of hypospadias may be at the crossroad of genetics and environment. The study of these factors taken individually failed to find an unequivocal explanation in most cases. But the interactions between exposure to endocrine disruptors chemicals (EDC) and genetic background have not yet been studied. We thus aimed to find a genetic susceptibility to the environment in hypospadias.Methods: Through a multicenter prospective comparativ...