Searchable abstracts of presentations at key conferences in endocrinology

ea0021p216 | Endocrine tumours and neoplasia | SFEBES2009

Expression and regulation of oestrogen sulfotransferase (EST) in human ovarian surface epithelium (OSE) and epithelial ovarian cancer (EOC)

Ren Xia , Harlow Chris , Fegan Scott , Mason Ian , Critchley Hilary , Hillier Stephen

Ovarian cancer is the most fatal of all gynaecological malignancies. EOC accounts for >90% of malignant ovarian tumours and is thought to originate mostly from OSE cells. Epidemiological data suggest EOC is oestrogen responsive and we previously showed active oestrogen could be produced locally by EOC cells, but not by normal OSE cells, through the combined activities of steroid sulfatase (STS) and 17╬▓hydroxysteroid dehydrogenase. We now investigate if EST, which conv...

ea0015p185 | Endocrine tumours and neoplasia | SFEBES2008

Steroid Sulphatase (STS) gene expression and regulation in normal human ovarian surface epithelium (OSE) and epithelial ovarian cancer (EOC)

Harlow Christopher R , Wu Xuan , Ren Xia , Fegan Scott , Rae Michael , Price Deborah , Mason J Ian , Hillier Stephen G

At least 90% of human ovarian cancers originate in the OSE. Most studies indicate that EOC is oestrogen responsive. Paradoxically, ovarian cancer generally occurs after the menopause, which raises the question if oestrogen is involved, where does it come from? We hypothesise that the high circulating concentrations of conjugated (inactive) oestrogens in post-menopausal women are substrates for formation of active oestrogen in the OSE through the hydrolytic enzyme activity of S...