Searchable abstracts of presentations at key conferences in endocrinology
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Society for Endocrinology BES 2010

Poster Presentations

Endocrine tumours and neoplasia

ea0021p188 | Endocrine tumours and neoplasia | SFEBES2009

Ovarian Leydig cell tumour in a peri-menopausal woman with severe hyperandrogenism and virilisation

Ullah Arif , Abouglila Kamal , Ibrahim Ibrahim

We present the case of a 50-year-old woman who presented with 12 months of amenorrhea associated with signs of virilisation. Investigations revealed markedly raised serum concentrations of testosterone (9 nmol/l), whereas sex hormone binding globulin, random cortisol, androstenedione, 17-hydroxyprogesterone and dehydroepiandrosterone sulphate concentrations were all within the normal range. Computed tomography scan of the pelvis and abdomen showed a slightly bulky right ovary,...

ea0021p189 | Endocrine tumours and neoplasia | SFEBES2009

Laparoscopic versus open adrenalectomy and adjuvant mitotane in adrenocortical carcinoma

Ali Sarah , Qureshi Asjid , Clarke Ian , Palazzo Fausto

Introduction: Adrenocortical carcinoma (ACC) is an uncommon aggressive malignancy. Despite surgical resection, recurrence rates are high. Two areas of contention currently involve treatment of ACC: the role of laparoscopic surgery in removal of large, potentially malignant tumours and the role of Mitotane. We present a case of a large adrenal tumour, later confirmed as ACC, where initially laparoscopic adrenalectomy was considered, and adjuvant Mitotane has been given despite ...

ea0021p190 | Endocrine tumours and neoplasia | SFEBES2009

An unusual presentation of insulinoma with postabsorptive hypoglycaemia?

Stolte Joachim , Iliopoulou Amalia , Holmes Simon , Nagi Dinesh

Insulinomas are rare neuroendocrine tumours with an estimated incidence of up to four new cases per mill./p.a. Most tumours are benign, <2 cm and arise from the islets of Langerhans.Typically patients present with Whipple’s triad: symptoms of hypoglycaemia, caused by fasting or exercise, low plasma glucose and symptoms relieved by Food. The diagnosis is confirmed by high insulin and c-peptide levels, inappropriately high for prevailing glucose.<...

ea0021p191 | Endocrine tumours and neoplasia | SFEBES2009

A family with functional extraadrenal paragangliomas and positive SDHB gene mutation

Polydorou Doro , Kenz Sami , Kannapan Daniel , Kearney Tara

Extradrenal paragangliomas can occur in individuals at any age although most arise in the fourth or fifth decade. Familial paragangliomas constitute approximately 10% of cases. These are part of a rare syndrome characterized by slow-growing tumors derived from paraganglia tissue. Recent years have brought significant progress in identifying the genetic etiology of this syndrome.Thirty-eight years old female was referred to the endocrine department by ENT...

ea0021p192 | Endocrine tumours and neoplasia | SFEBES2009

Medical management of an insulinoma – a safe long-term alternative to surgery?

Page Georgina , Cummings Michael

We present a 65-year-old lady initially diagnosed and treated for epilepsy who was subsequently referred 10 years later for the investigation of underlying spontaneous hypoglycaemia. Laboratory plasma glucose concentrations of 2.0 and 1.7 mmol/l were recorded prior to referral and subsequently a fasting challenge provoked hypoglycaemia associated with a plasma glucose of 0.8 mmol/l, C-peptide 371 pmol/l (NR 120–600) and insulin 7.4 mU/l (NR 0–10). CT and MRI imaging ...

ea0021p193 | Endocrine tumours and neoplasia | SFEBES2009

Two cases of meningitis as a complication of pituitary adenoma

Tan Horng Kai , Jayashekara Acharya , Flanagan Daniel

Introduction: Meningitis is a recognized complication of the treatment of pituitary adenoma. It is usually considered as a peri-operative problem but does need to be considered as a potential complication at other points in the treatment pathway. We present two patients with meningitis where the link to pituitary pathology was originally unrecognized.Case report:Patient 2: 41 years old lady, presented with a history of nasal drip u...

ea0021p194 | Endocrine tumours and neoplasia | SFEBES2009

A case of phaeochromocytoma mimicking an acute ischemic limb: an unusual presentation

Ahmed Ridwan , Raja U Y , Prasad Bheemasenachar , Rooney Matthew , Govindan R , Kumar Harish , Karandikar Sharad , Shakher Jayadave

Case: A 43-year-old Caucasian lady presented with an acutely painful, cold left leg to the vascular surgeons. She was being treated for respiratory tract infection in the community. She has been investigated for palpitations 7 years ago with no cause identified and headache 3 years ago with normal CT head. Her peripheral vascular examination was unremarkable, including a normal ankle brachial pressure index. She was admitted for further investigations to rule out an underlying...

ea0021p195 | Endocrine tumours and neoplasia | SFEBES2009

Ectopic Cushings complicated by paraneoplastic cerebral vasculopathy requiring high-dose steroid therapy

Jordan Alice , Parr John , Thomas Cecil , Wahid Shahid

In October 2006 a 53-year-old, non-smoking woman presented with ectopic Cushings from a small cell, undifferentiated carcinoma (Grade 3 neuroendocrine) from a 10 mm tumour at the left lung hilum (Cortisol: 09:00 a.m. 720 nmol/l; 24.00 mm 742 nmol/l. ACTH 114 ng/l). Four years before she had sustained a myocardial infarction, with atrial fibrillation, and was found to have Graves’ disease, being treated initially with carbimazole then radioactive iodine, becoming hypothyro...

ea0021p196 | Endocrine tumours and neoplasia | SFEBES2009

Cranioplasty for extensive skull deposit in the management of differentiated thyroid cancer

Putta-Manohar Sudeep , Cyriac Abby , Pearson Rachel , Mallick Ujjal , Perros Petros

Thyroid cancer if associated with bony metastases carries a poorer prognosis. Intensive multimodality treatment is usually necessary in management of these patients.Case: A 51-year-old female presented with hoarse voice in October 2005. Examination revealed a 3 cm left sided thyroid nodule and left vocal cord palsy. CT neck/thorax showed a multinodular goitre, with a dominant left nodule. FNA showed appearances suggestive of a follicular neoplasm. She un...

ea0021p197 | Endocrine tumours and neoplasia | SFEBES2009

Pseudophaeochromocytoma syndrome associated with Modafinil

Htwe Nyi , Jacob Koshy

A 48-year man, referred with symptoms suggestive of phaeochromocytoma and elevated 24 h urinary noradrenalin level. He had a background history of obstructive sleep apnoea, controlled hypertension and obesity. His medications included Amlodipine 10 mg od, Modafinil 200 mg daily, Amitriptyline 10 mg and Rabeprazole.Obstructive sleep apnoea was diagnosed at 39 years. CPAP was tried and later Modafinil 100 mg daily. A few months prior to referral his Modafi...

ea0021p198 | Endocrine tumours and neoplasia | SFEBES2009

An unusual case of rapidly progressing pituitary lesion

Manjunatha Rashmi , Nayak Ullal Ananth , Krishnaswamy Senthil , Buch Harit

Case: An 81-year-old man with type 2 diabetes, cerebrovascular disease and hypertension presented with a sudden onset of headache. CT scan and MRI scan of the head did not show any significant abnormality. Headache improved spontaneously and he was discharged with no cause for his headache being identified. Four months later he was diagnosed to have pan-anterior hypopituitarism at another hospital and was commenced on appropriate replacement therapy. Serum prolactin was not el...

ea0021p199 | Endocrine tumours and neoplasia | SFEBES2009

Cinacalcet treatment of resistant hypercalcaemia due to MEN1-associated primary hyperparathyroidism in pregnancy

Wysota Barbara , Horne Stephanie , Smyth Angharad , Anwar Aresh , Sankar Sailesh , Weickert Martin

Cinacalcet increases sensitivity of the calcium sensing-receptor, currently licenced for treatment of refractory secondary hyperparathyroidism in patients with end-stage renal disease. It decreases parathyroid hormone, calcium and phosphorus levels. There is no clinical data for the use of Cinacalcet in pregnancy. Hyperparathyroidism is rare during pregnancy, mainly presenting early, when surgery is safely performed. Here we report a patient presenting with a MEN1-associated p...

ea0021p200 | Endocrine tumours and neoplasia | SFEBES2009

A case of Carcinoid syndrome without liver metastasis

Ranaweera Nilushi , Richardson Tristan

Carcinoid tumours are neuroendocrine tumours characterised by production of serotonin (5-hydroxytriptamine, 5-HT) and tachykinins. Carcinoid syndrome occurs approximately in 10% of carcinoid tumours and symptoms arise when these vasoactive substances enter the systemic circulation escaping hepatic degradation. This normally occurs with metastasis to the liver or bronchus.We present a case of a 66-year-old woman who presented with carcinoid syndrome in th...

ea0021p201 | Endocrine tumours and neoplasia | SFEBES2009

Choroidal malignant melanoma in a patient with Carney complex

Farook Seleena , Gibson Christine , Davis Julian

We report a case of Carney complex who demonstrated most of the disease-defining features and an unusual manifestation of choroidal malignant melanoma not previously reported in the literature.A 16-year-old female patient initially presented to the endocrinologists in 1991 with secondary amenorrhea and raised prolactin levels, diagnosed to have a pituitary microprolactinoma. Past history included episodes of vague syncope and palpitations treated as comp...

ea0021p202 | Endocrine tumours and neoplasia | SFEBES2009

A rare case of steroid responsive non-islet cell tumour hypoglycemia (NICTH) secondary to metastatic haemangiopericytoma

Mon Aung , Ahluwalia Rupa , Tehseen Saffia , Rathore Ali , Weston Philip , Ahmad Aftab

Introduction: Spontaneous hypoglycaemia is very rarely related to non-islet cell tumours. Most of them are due to mesenchymal tumours including haemangiopericytoma (HAP). It has been reported that, in patients with NICTH who have inoperable tumours, high doses of glucocorticoid or recombinant human growth hormone may be effective in treating hypoglycaemia. We present, with relevant imaging, a rare case of metastatic HAP causing an increased level of insulin like growth factor ...

ea0021p203 | Endocrine tumours and neoplasia | SFEBES2009

Adrenal venous sampling for catcholamines- a normal value study

Freel E Marie , Stanson Anthony , Thompson Geoffrey , Grant Clive , Farley David , Richards Melanie , Young William

Context: Phaeochromocytomas are rare, but potentially fatal, neoplasms. The diagnosis and localization of phaeochromocytoma can be challenging and recently there has been some debate regarding the role for adrenal venous sampling (AVS). The utility of AVS in this setting is hampered by a lack of normative value data for adrenal vein catecholamine concentrations and the reliability of lateralization ratios. We sought to address these concerns by analyzing AVS catecholamine conc...

ea0021p204 | Endocrine tumours and neoplasia | SFEBES2009

Temozolomide-induced regression of hepatic metastases in a pituitary corticotroph carcinoma with low O6-methylguanine-DNA methyltransferase expression

Burton Hannah , Annamalai Anand K , Dean Andrew , Kovacs Kalman , Antoun Nagui , Kirollos Ramez W , Simpson Helen L , Jeffries Sarah J , Burnet Neil G , Gurnell Mark

Background: Pituitary carcinoma occurs in ~0.2% of resected pituitary tumours, and carries a poor prognosis (mean survival <4 years), with standard chemotherapeutic regimens showing limited efficacy. However, recent evidence suggests that temozolomide, an orally active alkylating agent used principally in the management of glioblastoma, may also be effective in controlling aggressive/invasive pituitary adenomas/carcinomas. Low levels of expression of the DNA-repair enzyme ...

ea0021p205 | Endocrine tumours and neoplasia | SFEBES2009

Secretory glomus jugulare tumour treated with steriotactic radio surgery

Kulambil Padinjakara R N , Sivaraman Subash , Dutton David , Murthy N P N , Weickert Martin , Sayed Ateeq , Randeva Harpal , Shankar Sailesh

Glomus jugulare tumours are rare and often difficult to manage. A small proportion of these tumours (1–3%) can cause symptoms due to catecholamine secretion. Here we describe a patient with secretory glomus jugulare tumour treated with steriotactic radio surgery and its effect on catecholamine secretion.Case report: A 39-year-old lady was referred to ear specialists with the characteristic symptoms of pulsatile tinnitus and decreased hearing in the ...

ea0021p206 | Endocrine tumours and neoplasia | SFEBES2009

Case report: multiple endocrine neoplasia type 2a and hereditary haemorrhagic telangiectasia presenting consecutively in a single patient

Hussein Omer , Crowley Rachel , Sheahan Patrick , Brady Adrian , Tuthill Antoinette

Multiple endocrine neoplasia type 2a (MEN 2a) is an autosomal dominant disorder with an incidence of ~1 in 30 000 of the population. It is characterized by medullary thyroid cancer (MTC), benign or malignant phaeochromocytomas, and parathyroid hyperplasia or tumours.Hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu syndrome), is also an autosomal dominant disorder; this condition occurs with an incidence of ~1–2 per 100 000 of the population....

ea0021p207 | Endocrine tumours and neoplasia | SFEBES2009

Parathyroidectomy has no impact on haemoglobin levels on patients with primary hyperparathyroidism

Sundar Siva , Sadler Gregory , Mihai Radu

Background: Mild primary hyperparathyroidism (PHPT) is frequently diagnosed in patients with minimal hypercalcaemia whose symptoms might remain sub-clinical or even be absent. In contrast, series of patients with severe PHPT report multiple end-organ failures including suppressed haematopoiesis (Horm Metab Res 1997; 29: 387) and marrow fibrosis (Clin Endo 2009; 70 :527).Aim: To determine the effect of parathyroidectomy on haem...

ea0021p208 | Endocrine tumours and neoplasia | SFEBES2009

Low incidence of hypocalcaemia after thyroidectomy in patients administered routinely oral calcium supplements

Herzog Jan , Mihai Radu

Background: The national audit from the British Association of Endocrine Surgeons and the Scandinavian Quality Register of Thyroid and Parathyroid Surgery have reported that 7–17% of patients have hypocalcaemia in the first 6 weeks after thyroid surgery. This study is a snap-shot of management of peri-operative hypocalcaemia using routine Calcichew supplements.Methods: Retrospective review clinical and biochemical data on consecutive p...

ea0021p209 | Endocrine tumours and neoplasia | SFEBES2009

Utilization of various imaging modalities in the localization of tumours in MEN-1 and insulinoma

Ma Claire , Muthukuda Dimuthu , Carroll Nicholas , Whitley Sobhan , Simpson Helen

Objective: A descriptive study to summarize the experience on diagnosis of NET using various imaging modalities.Methods: Imaging was reviewed for 25 patients between 2002 and 2009 (22 MEN-1, 3 sporadic insulinoma). Of 13/25 had elevated fasting gut hormones. CT, MRI, endoscopic ultrasound (EUS), somatostatin receptor scintigraphy (SRS) and angiography were reviewed. (CT, MRI examined with arterial enhancement).Results: Most frequen...

ea0021p210 | Endocrine tumours and neoplasia | SFEBES2009

Functional characterisation of aryl hydrocarbon receptor interacting protein (AIP) promoter and silent mutations

Igreja Susana , Chahal Harvinder , King Peter , Bolger Graeme , Srirangalingam Umasuthan , Guasti Leonardo , Chappel Paul , Gueorguiev Maria , Guegan Katie , Stals Karen , Khoo Bernard , Kumar Ajith , Ellard Sian , Grossman Ashley B , Korbonits Marta

AIP mutations predispose to familial isolated pituitary adenomas (FIPA) and 45 different AIP mutations have been described in the literature. Most of these mutations result in complete disruption of the C-terminal region of the AIP protein due to early stop codons. In this study we were particularly interested in the effect of AIP mutations in the promoter region (−270−−269CG & −220C) and 2 synonymous mutations (c.249G>T, p.G83= and c...

ea0021p211 | Endocrine tumours and neoplasia | SFEBES2009

Investigating the role of HIF-1α in tumour growth and metastasis in an in vivo model of thyroid cancer

Burrows Natalie , Resch Julia , Mejin Melissa , Brabant Georg , Williams Kaye

Intratumoural hypoxia is associated with aggressive and metastatic phenotypes with poor prognosis. The transcription factor HIF-1α is a key regulator of hypoxia-mediated gene expression that is documented to promote tumour growth and metastasis in a wide range of cancers. However its role in the development of thyroid carcinomas is relatively unknown. We have previously shown that HIF-1α is highly active in a range of thyroid cancer cell lines with highest activity o...

ea0021p212 | Endocrine tumours and neoplasia | SFEBES2009

Routine central compartment lymph node dissection for papillary thyroid cancer has minimal impact on early postoperative parameters

Parameswaran Rajeev , Stechman Michael , Weaver Andrew , Sadler Gregory , Mihai Radu

Background: Arguably patients undergoing total thyroidectomy for papillary thyroid cancers (PTC) are more likely to have negative radioactive iodine uptake and low/undetectable thyroglobulin levels if the central compartment lymph node dissection (CCLND) is performed routinely irrespective of the macroscopic appearance of the LN. The aim of this study was to determine whether routine CCLND leads to more favourable outcome in the first year after treatment for well-differentiat...

ea0021p213 | Endocrine tumours and neoplasia | SFEBES2009

Concordance between thyroglobulin antibody assays

Parkington Damon , Littleboy Sonia , Taylor Kevin , Jeffries Sarah , Simpson Helen , Halsall David

As thyroglobulin antibodies (TgAb) are a well recognised cause of interference in thyroglobulin (Tg) immunoassays current guidelines recommend that TgAb should be measured concurrently with Tg when monitoring thyroidectomised thyroid cancer patients. However the concordance between different TgAb assays has been questioned despite the availability of an International TgAb Reference Preparation (MRC 65/93).Four commonly used TgAb assays were tested in 145...

ea0021p214 | Endocrine tumours and neoplasia | SFEBES2009

Mutations of the transcription factor, GATA3, in oestrogen receptor positive breast cancers

Gaynor Katherine , Grigorieva Irina , Esapa Chris , Head Rosie , Christie Paul , Nesbit Andrew , Jones Louise , Thakker Rajesh

Mutations of the transcription factor GATA3, which is important for maintaining human breast luminal epithelial cell differentiation and quiescence, have been reported in 17 oestrogen receptor (ER) positive breast cancers, although the functional effects of these mutations have not been studied. We therefore investigated 56 ER-positive breast cancers for GATA3 mutations. The tumours were macrodissected, and immunohistochemistry for GATA3 revealed a strong correlation between E...

ea0021p215 | Endocrine tumours and neoplasia | SFEBES2009

Receptor-based scintigraphic imaging of insulinoma and glucagonoma in MEN-1

Sivappriyan Sivasubramaniam , Kurzawinski Tom , Bomanji Jamshed , Conway Gerard , Ahlquist James

Successful surgery for pancreatic neuro-endocrine tumours (NET) requires accurate tumour localisation. Interpretation of cross-sectional imaging is often difficult, particularly after pancreatic surgery. Imaging by somatostatin-receptor-scintigraphy with indium-labelled octreotide may be useful in identifying recurrent disease; however, octreotide scans may be negative in some pancreatic NET, due to a low level of expression of somatostatin receptors. The GLP-1 receptor is abu...

ea0021p216 | Endocrine tumours and neoplasia | SFEBES2009

Expression and regulation of oestrogen sulfotransferase (EST) in human ovarian surface epithelium (OSE) and epithelial ovarian cancer (EOC)

Ren Xia , Harlow Chris , Fegan Scott , Mason Ian , Critchley Hilary , Hillier Stephen

Ovarian cancer is the most fatal of all gynaecological malignancies. EOC accounts for >90% of malignant ovarian tumours and is thought to originate mostly from OSE cells. Epidemiological data suggest EOC is oestrogen responsive and we previously showed active oestrogen could be produced locally by EOC cells, but not by normal OSE cells, through the combined activities of steroid sulfatase (STS) and 17βhydroxysteroid dehydrogenase. We now investigate if EST, which conv...

ea0021p217 | Endocrine tumours and neoplasia | SFEBES2009

Is the anti-proliferative effect of AIP (aryl hydrocarbon receptor interacting protein) via ZAC transcription factor?

Alband Neda , Igreja Susanna , Chahal Harvinder S , Grossman Ashley B , Korbonits Marta

Background: Pituitary adenomas are relatively common in the general population, but the pathogenesis of these tumours remains largely unknown. Recently, germline mutations have been described in the AIP (aryl hydrocarbon receptor interacting protein) gene in several patients with familial isolated pituitary adenomas (FIPA). This gene is located on chromosome 11q13 and loss of heterozygosity at this locus as well as functional data from our group demonstrates a tumour suppresso...

ea0021p218 | Endocrine tumours and neoplasia | SFEBES2009

The role of PBF in NIS and MCT8 cellular trafficking

Smith Vicki , Read Martin , Watkins Rachel , Lewy Gregory , Fong Jim , Seed Robert , Sharma Neil , Ryan Gavin , Boelaert Kristien , Franklyn Jayne , McCabe Christopher

Ablative therapy for thyroid cancer depends upon the adequate uptake of radioiodine via the sodium iodide symporter (NIS). However, thyroid tumours frequently show reduced iodide uptake, impacting on prognosis. We previously demonstrated that the proto-oncogene PBF binds NIS and modulates its subcellular localisation. We now demonstrate that PBF binds the thyroid hormone transporter MCT8 in GST-pulldown assays, and alters MCT8 subcellular localisation in vitro. To inves...

ea0021p219 | Endocrine tumours and neoplasia | SFEBES2009

MEN2B patients with a RET A883F mutation have less aggressive MTC than those with the common RET M918T mutation

Worth Gabriella , Palazzo Fausto , Tolley Neil , Robinson Stephen , Cox Jeremy , Williams Graham , Bassett Duncan

MEN2B is the most aggressive form of MEN2. Consequently, the new American Thyroid Association guidelines recommend prophylactic thyroidectomy early in the first year of life. Ninety-seven percentage of MEN2B cases result from a germline methionine to threonine mutation at codon 918 (M918T) of the RET proto-oncogene. In addition, an exceedingly rare alanine to phenylalanine mutation at codon 883 (A883F) has been reported in 4 unrelated adults. In each case metastatic MTC and th...

ea0021p220 | Endocrine tumours and neoplasia | SFEBES2009

First report of SOX2 loss of function associated with a large hypothalamo-pituitary tumour; further insights into the role of SOX2 in pituitary development

Alatzoglou Kyriaki S , Arriazu Maria Cristina , Crolla John , Martinez-Barbera Juan Pedro , Roubicek Martin , Buchanan Charles , Dattani Mehul T

Background: SOX2 is a member of the SOX family of transcription factors (SRY-related high-mobility group (HMG) box). Heterozygous, de novo, loss-of-function mutations were initially reported in patients with bilateral anophthalmia/microphthalmia, developmental delay, male genital tract abnormalities, oesophageal atresia and sensorineural hearing loss. We have recently reported a number of SOX2 mutations in patients with anterior pituitary hypoplasia and hy...

ea0021p221 | Endocrine tumours and neoplasia | SFEBES2009

Pro-opiomelanocortin is a novel biomarker for small cell lung cancer

Stovold Rachel , Stevens Adam , Ray David , Sommers Paula , Dive Caroline , Blackhall Fiona , White Anne

Small cell lung cancer (SCLC) is an aggressive neuroendocrine tumour that shows early metastasis and resistance to chemotherapy. Current biomarkers focus on prognosis and diagnosis but there is a need to find novel biomarkers, which could, for example, identify patients at risk of cerebral metastases.Pro-opiomelanocortin (POMC), the precursor of ACTH is a well-recognised biomarker of the ectopic ACTH syndrome1, of which SCLC is the most preval...

ea0021p222 | Endocrine tumours and neoplasia | SFEBES2009

Parafibromin, a tumour suppressor protein, interacts with transforming acidic-coiled coil protein 3 and kinesin family member 5B

Newey Paul , Bowl Michael , Gergely Fanni , Thakker Rajesh

Parafibromin is a tumour suppressor protein, encoded by the gene responsible for the hyperparathyroidism-jaw tumour (HPT-JT) syndrome, which is an autosomal dominant disorder, characterised by parathyroid tumours, ossifyfing fibromas, renal and uterine tumours. Parafibromin is a component of the polymerase-associated factor 1 (PAF1) complex and interacts directly with β-catenin, although these functions do not fully explain its role in tumourigenesis. To further investiga...

ea0021p223 | Endocrine tumours and neoplasia | SFEBES2009

Open or laparoscopic surgery for phaeochromocytoma

Ezzat Tarek , Skipworth James , Raptis Dimitris , Conway Gerard , Baldweg Stefie , Bomanji Jamshed , Bouloux Pierre , Rolles Keith , Khoo Bernard , Hyatt Penny , Rossi Michaela , Barnard Maria , Anthony Karen , Stojanovic Nemanja , Cohen Mark , Katz Jonathan , Baynes Christopher , Russel Sabina , Ahlquist James , Kurzawinski Tom

Background: Surgical resection is the treatment of choice for phaeochromocytomas. Introduction of laparoscopic adrenalectomy (LA) led to a reduction in the number of open adrenalectomies (OA); however, there is limited information comparing the two techniques.Objectives: We report here a comparison of LA and OA operations for phaeochromocytoma performed over 20 years.Methods: We performed a retrospective review of all patients unde...

ea0021p224 | Endocrine tumours and neoplasia | SFEBES2009

PBF is induced by ionising radiation and functionally inactivates p53 in thyroid cancer

Seed Robert , Read Martin , Fong Jim , Lewy Gregory , Smith Vicki , Watkins Rachel , Kwan Perkin , Sharma Neil , Ryan Gavin , Franklyn Jayne , Boelaert Kristien , McCabe Christopher

The pituitary tumor transforming gene-binding factor (PBF) is a poorly characterised gene that is over expressed in pituitary and thyroid tumours. Recently we showed that subcutaneous expression of PBF elicits tumours in nude mice, and expression correlates with thyroid tumour recurrence in man. Given the established role of ionising radiation in thyroid tumourigenesis we have now investigated the relationship between PBF and the tumour suppressor protein p53. Initially, we de...

ea0021p225 | Endocrine tumours and neoplasia | SFEBES2009

Mitotane treatment has profound effects on cortisol catabolism

Ghataore Lea , Abraha Hagosa , Chakraborti Indrani , Taylor Norman , Aylwin Simon , Schulte K-M

Mitotane (o,p’DDD) is an effective oral adrenolytic agent for treatment of advanced adrenocortical carcinoma (ACC). Inhibition of cortisol biosynthesis has been described. Cortisol metabolic clearance rate is unchanged, but decreased cortisol biovailability is indicated by increased dose requirement for hydrocortisone replacement during mitotane treatment. Urinary excretion of common cortisol metabolites (CM) has been reported to be normal but with increase of 6β-hyd...

ea0021p225.1 | Endocrine tumours and neoplasia | SFEBES2009

The microRNA let-7a is downregulated in pituitary tumours from a multiple endocrine neoplasia type-1 mouse model

Dyar Rebecca , Newey Paul , Nesbit Andrew , Walls Gerard , Thakker Rajesh

MicroRNAs are highly conserved non-coding RNAs that regulate diverse cellular processes. Altered microRNA expression is observed in many human cancers and microRNAs may have tumour suppressor or oncogenic properties. One group of putative tumour suppressor microRNAs is the let-7 family whose expression is reduced in several human tumours, and which inhibit the expression of several oncogenes including HMGA2 and K-Ras. Let-7 expression have also been observed to b...