Searchable abstracts of presentations at key conferences in endocrinology

ea0063gp84 | Thyroid Nodules and Cancer | ECE2019

Polygenic susceptibility to papillary thyroid cancer: detection of the main genetic signature in Italian patients

Brigante Giulia , Lazzaretti Clara , Paradiso Elia , Foersti Asta , Hemminki Kari , Elisei Rossella , Romei Cristina , Simoni Manuela , Landi Stefano , Casarini Livio

Introduction and aim: Thyroid cancer is the most common endocrine neoplasia affecting 0.2–1.5% of the individuals worldwide and its incidence is increasing [1]. Papillary thyroid carcinoma (PTC) is the main histotype (80–90%). PTC susceptibility is the result of genetic predisposition, environmental factors and lifestyle. We hypothesized that genetic predisposition to PTC is poligenic and characterized by a genetic signature involving combinations of genes previously...