Searchable abstracts of presentations at key conferences in endocrinology

ea0044cmw4.1 | Workshop 4: How do I manage…(Supported by Endocrinology, Diabetes & Metabolism Case Reports) | SFEBES2016

How should I counsel a young woman with PCOS about fertility?

Franks Stephen

Fertility problems in women with PCOS are by no means inevitable. Indeed women who have symptoms of PCOS have at least one child just as often as those who do not have PCOS. But there is no doubt that women with PCOS who have oligo- or amenorrhoea are likely to require induction of ovulation and, in these circumstances, the sooner they seek the appropriate treatment for induction of ovulation, the better the chances of a timely pregnancy....

ea0059mc1.2 | Masterclass 1: PCOS | SFEBES2018

Polycystic ovary syndrome: management

Franks Stephen

Polycystic ovary syndrome (PCOS) is the commonest cause of anovulatory infertility, menstrual disturbances and hirsutism. PCOS is also associated with a metabolic disturbance characterised by hyperinsulinaemia and insulin resistance. Women with PCOS are at increased long-term risk of developing type 2 diabetes (T2DM) and carry a significant risk factor profile for cardiovascular disease. Obesity amplifies both reproductive and metabolic dysfunction. A growing body of evidence ...

ea0021d2 | (1) | SFEBES2009

This house believes that androgen replacement therapy, to get things going, should be offered to every hypogonadal woman

Franks Stephen

‘This house believes that androgen replacement therapy, to get things going, should be offered to every hypogonadal woman’.In opposing this motion, I shall review the advantages and disadvantages of androgen replacement therapy and draw attention to the folly of offering treatment to every hypogonadal women....

ea0021sig3.4 | PCOS Special Interest Group Session | SFEBES2009

Diagnosis and differential diagnosis of PCOS

Franks Stephen

Polycystic ovary syndrome (PCOS) is the commonest cause of anovulatory infertility, menstrual disturbances and hirsutism. In its classic form the presentation is of amenorrhoea or oligomenorrhoea associated with clinical and/or biochemical evidence of hyperandrogenism. However, it is clear that the spectrum of presenting symptoms of women with polycystic ovaries is wide, including anovulation without hirsutism (androgen levels are usually raised) and hirsutism with regular cyc...

ea0025p277 | Reproduction | SFEBES2011

Increased intensity of P450c17 protein expression in theca cells from polycystic ovaries

Comim Fabio , Hardy Kate , Franks Stephen

Background/aims: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women, being characterized by ovarian hyperandrogenism attributed to intrinsic overproduction by theca cells (TCs). Although previous reports pointed a higher stability and transcription of CYP17mRNA (Wickenheisser JK et al. 2006)1, few have examined (and none has quantified) P450c17 protein expression in TCs from PCOS ovaries. Therefore, the aim of this study is to qua...

ea0015p289 | Reproduction | SFEBES2008

Reduced expression of insulin receptor substrate-1 (IRS-1) protein in oocytes of polycystic ovaries

Stubbs Sharron , Hardy Kate , Franks Stephen

Insulin resistance is common in women with PCOS. Insulin and IGF-1 affect glucose uptake and metabolism via insulin receptor substrate (IRS-1) and the phosphotidyl inositol-3-kinase (PI3K) pathway. Impaired glucose metabolism has been observed in granulosa-lutein cells from anovulatory (but not ovulatory) women with PCO (Rice et al. 2005). The aim of this study was to analyse IRS-1 protein expression in human preantral follicles in samples of normal and PCO. Immunohisto...

ea0013oc29 | Neuroendocrinology, reproduction and cardiovascular | SFEBES2007

Effects of insulin-like growth factor 1 (IGF-1) on early folliculogenesis in polycystic ovaries from ovulatory and anovulatory women

Stubbs Sharron A , Hardy Kate , Franks Stephen

Preantral follicle development in polycystic ovaries (PCO) is characterised by an increased proportion of early growing follicles. We have previously shown that IGF-1 stimulates initiation of follicle growth in normal and PCO (Endocrine Abstracts 2004 7 P172). Here we have extended these studies, specifically to examine whether the ovulatory status of the patients from whom tissue is obtained influences the response to IGF-1. Small ovarian biopsies were obtained (with ethical ...

ea0012p114 | Reproduction | SFE2006

Effect of serum testosterone concentrations on outcome of induction of ovulation by low-dose FSH in women with polycystic ovary syndrome (PCOS)

Gorry Anwen , White Davinia , Franks Stephen

The recent recommendations from the joint ESHRE/ASRM expert panel regarding the definition of PCOS (the so-called Rotterdam Criteria) have given rise to considerable controversy, particularly over the inclusion of anovulatory women with polycystic ovaries (PCO) but without evidence of androgen excess. We reviewed the results of a large series of anovulatory women with PCO who have been treated with low-dose FSH at our centre with the aim of investigating the impact of serum te...

ea0065p353 | Reproductive Endocrinology and Biology | SFEBES2019

Differential expression in granulosa-lutein (GL) cells from polycystic ovaries of genes implicated in assembly and modification of extracellular matrix (ECM)

Hardy Kate , Hopkins Thomas , Lerner Avigdor , Green Orla , Franks Stephen

Introduction: Polycystic ovary syndrome (PCOS) is the commonest endocrine disorder in women and polycystic ovaries are characterized by excess ovarian stroma that has implications for disordered follicle development in PCOS. The factors contributing to proliferation and increased density of stroma remain unclear but local overproduction of androgens may be involved.Aim: To examine differential expression of genes that regulate key proteins that comprise ...

ea0062p36 | Poster Presentations | EU2019

A case of meningioma associated with long-term use of cyproterone acetate

Owens Lisa , Halliday Jane , Kerr Richard , Franks Stephen

Case history: A 58 year old woman presented to her GP when her family members noted prominence of her left eye. She had a background history of polycystic ovary syndrome (PCOS). Her main symptom of PCOS was hirsutism. She had been treated initially with the combined oral contraceptive pill ‘Dianette’ (ethinyloestradiol/cyproterone) but had also been treated intermittently with varying doses of 25–100 mg cyproterone acetate (CPA) 10 days/cycle. Post menopause she...