ea0016p454 | Neuroendocrinology | ECE2008
Jaffrain-Rea Marie-Lise
, Spilioti Cristina
, Vanbellinghen Jean-Francois
, Daly Adrian
, Gargano Donatella
, D'Innocenzo Emanuela
, Giangaspero Felice
, Tichomirowa Maria
, Esposito Vincenzo
, Ventura Luca
, Naves Luciana
, Alesse Edoardo
, Beckers Albert
Background: Germline AIP mutations confer a predisposition to pituitary adenomas (PA), usually in the setting of familial isolated pituitary adenomas (FIPA); AIP mutations account for 50% of familial acromegaly. AIP-related PA are GH, PRL-secreting or non-secreting. Little is known about AIP expression in PA. Although the prevalence is low, identifying AIP mutations in apparently sporadic PA is important for studying at-risk relatives. Pre-screening criteria would help select ...