Searchable abstracts of presentations at key conferences in endocrinology
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10th European Congress of Endocrinology

Poster Presentations


ea0016p377 | Neuroendocrinology | ECE2008

Turner syndrome: body composition and psychological state

Lasaite Lina , Lasiene Danute , Lasas Liudvikas

Introduction: Turner syndrome (TS) is female genetic disorder arrising from loss of X-chromosome material, associated with characteristic physical neuropsychological features.Objective: Examine peculiarities of body composition, cognitive functions, emotional state, quality of life (QoL) of TS patients after discontinued growth hormone (GH) therapy.Patients and methods: Eighteen girls (age 21.47±4.09 years) with diagnosis of T...

ea0016p378 | Neuroendocrinology | ECE2008

Can early evening melatonin treatment prevent relapse after sleep deprivation?

Putilov Arcady , Danilenko Konstantin

Patients with winter depression (seasonal affective disorder) respond beneficially to sleep deprivation and bright light, but the mechanisms of these responses remain unknown. The study was designed to test whether afternoon/evening melatonin can prevent further relapse after sleep deprivation (presumably due to a pharmacologically induced advance shift of circadian phase). Compared to phase advancing by alteration of sleep-wake schedule or by bright light exposure, the melato...

ea0016p379 | Neuroendocrinology | ECE2008

Reduction of food intake by insulin detemir in comparison to regular human insulin

Hallschmid Manfred , Jauch-Chara Kamila , Lehnert Hendrik , Born Jan , Kern Werner

Systemic insulin is considered to serve as a major negative feedback signal in the central nervous regulation of food intake. Accordingly, euglycemic infusion of regular human insulin (RI) has been shown to reduce hunger in a dose dependent fashion. Due to its increased lipophility, the long-acting insulin analogue insulin detemir (DI) might cross the blood–brain barrier faster and in higher quantities than RI and exceed stronger anorexigenic effects. To test this hypothe...

ea0016p380 | Neuroendocrinology | ECE2008

Pituitary insufficiency after traumatic brain injury and the coherence with psychological disorders

Wachter Dorothee , Guendling Katja , Oertel Matthias F , Stracke Hilmar , Boeker Dieter-Karsten

Objective: In order to explain physical, cognitive and psychological disorders after traumatic brain injury (TBI), several studies have implicated a major role of posttraumatic pituitary insufficiency (prevalence 25–70%). Aim of this study was to determine the correlation between cerebral tissue damage, corresponding initial findings on radiographic imaging and pituitary insufficiency versus psychological disorders (like fatigue, nervousness, depression or excitability).<...

ea0016p381 | Neuroendocrinology | ECE2008

Review of pituitary adenomas diagnosed in Burgos (Spain)

Garcia Elena , Alvarez Maria Pilar , Garcia-Hierro Victor , De la Maza Laura , Santos Estefania , Pi Javier , Castillo Luis , Ruiz Enrique

Introduction: Pituitary adenomas are the most common cause of sellar masses from the third decade on, accounting for up to 10 percent of all intracraneal neoplasms.Objective: To review pituitary adenomas diagnosed in Burgos.Patients and methods: It was a retrospective study in which we reviewed a total of 90 pituitary adenomas detected in Burgos from 1983 to our days.Results: About 65% were macroadenomas and ...

ea0016p382 | Neuroendocrinology | ECE2008

Residual adverse vascular risk and oxidative stress in treated adult panhypopituitarism

Mukherjee Annice , Charlton-Menys Val , Trainer Peter , Chobotova Jelena , Durrington Paul , Shalet Stephen

Background: Adult hypopituitarism is associated with premature vascular mortality for which the underlying mechanisms are unknown but untreated GH deficiency is proposed as a potential contributor.Objectives: To characterise vascular risk, including paraoxonase-1 (PON1; an antioxidant enzyme which preserves LDL against oxidation), in adults with treated panhypopituitarism.Study subjects: The study had full ethics approval. Data are...

ea0016p383 | Neuroendocrinology | ECE2008

Is total and acylated ghrelin secretion after oral glucose modified by acromegaly?

Cordido Fernando , Penin Manuel , Isidro Luisa , Nemina Rosa , Sangiao Susana , Vidal Ovidio , Martinez Teresa , Jesus Garcia-Buela

Introduction: Although involved in feeding and weight homeostasis, stimulation of pituitary GH secretion is the best established action of stomach-produced hormone ghrelin. However, its role in regulation of GH secretion is not yet clear. Some evidence indicates that circulating concentrations of GH and/or IGF-I could influence ghrelin levels. The pathophysiology of ghrelin secretion in acromegaly (specially aftar an oral glucose tolerance test (OGTT) is unclear.<p class="...

ea0016p384 | Neuroendocrinology | ECE2008

Hypothalamic–pituitary insufficiency following infectious diseases of the central nervous system

Schaefer Stephan , Boegershausen Nina , Meyer Silke , Ivan Diana , Schepelmann Karsten , Kann Peter Herbert

Hypothalamic–pituitary insufficiency may have diverse causes. Infectious diseases of the central nervous system (CNS) may also affect the hypothalamus and/or the pituitary, although this has not been reported very often and not yet been studied systematically. It was the aim of this study to determine the incidence of hypothalamic–pituitary insufficiency in patients with previous infectious diseases of the CNS of different etiology.Patient seri...

ea0016p385 | Neuroendocrinology | ECE2008

The choice of therapy in acromegaly: results of treatment at a tertiary care hospital

Isidro Ma Luisa , Castro Jose Antonio , Penin Manuel , Armenta Jacinto , Cordido Fernando

Objective: The aim of our study was to investigate the characteristics of the acromegalic patients followed at a tertiary Universitary Hospital and to evaluate the results of the recommended treatment protocols.Patients and methods: All our acromegalic patients were included (n=48; 27 women). Demographic, hormonal, visual and imaging data at diagnosis and during follow-up, as well as treatments applied, were recorded.Results...

ea0016p386 | Neuroendocrinology | ECE2008

Isolated GH deficiency of adult-onset in the KIMS database: prevalence, clinical presentation, and response to GH replacement

Casanueva Felipe , Abs Roger , Popovic Vera , Koltowska-Haggstrom Maria , Jonsson Bjorn , Saller Bernhard , Kourides Ione

Of the ~12 500 GH treated subjects with adult-onset GH deficiency (GHD) in KIMS (Pfizer International Metabolic Database), 3744 with multiple pituitary hormone deficiencies (MPHD) and 367 (9%) with isolated GHD (iGHD) were eligible for baseline analysis. Subjects met the following inclusion criteria: 1) never received GH prior to entry in KIMS, 2) had stimulation tests with insulin or glucagon (GH<3 μg/l), arginine (GH<0.4 μg/l), or arginine+GHRH (cut-offs ba...

ea0016p387 | Neuroendocrinology | ECE2008

Efficacy of slow release formulation of lanreotide (Somatuline Autogel® 120 mg) in patients with acromegaly: single center experience

Miljic Dragana , Nikolic-Djurovic Marina , Doknic Mirjana , Pekic Sandra , Stojanovic Marko , Popovic Vera

Somatuline Autogel® 120 mg (SATG, Ipsen, Sweeden) is a high dose sustained release aqueous gel formulation, supplied in a prefiled syringe and given by deep subcutaneous injection. The aim of this cross-sectional hospital based study, approved by the local ethical committee, was to investigate efficacy and tolerability of SATG given every 4 weeks in patients with active acromegaly.Twenty patients (9f, 11m) aged 42.9±17.8 (range 17&#1...

ea0016p388 | Neuroendocrinology | ECE2008

Smoking causes increased androgen levels in perimenopausal women

Karaoulanis Sokratis , Rizoulis Andreas , Ntamani Eleni , Rizouli Katerina , Liakos Nikos , Xiromeritis Athanasios , Nasika Zoi , Papadimitriou Aleksandros , Angelopoulos Nikiforos

Introduction: Several studies have investigated determinants for androgen levels in men, but few studies have included women. Epidemiological evidence has suggested that cigarette smoking has an anti-oestrogenic effect in women, but the effects of smoking on steroid hormone metabolism are not fully understood. We investigated whether there is a relationship between androgen levels and smoking in perimenopausal women.Material and methods: We examined 75 p...

ea0016p389 | Neuroendocrinology | ECE2008

Body fat excess and GH-stimulated levels in adult patients with Prader–Willi syndrome

Grugni Graziano , Crino Antonino , Bertocco Paride , Sartorio Alessandro , Marzullo Paolo

The GH response to standard provocative tests is significantly lower in adult patients with Prader–Willi syndrome (PWS) than obese controls with similar body mass index (BMI). Nevertheless, BMI is an inadequate measure of body composition in PWS, because PWS harbour a higher fat mass than simple obesity, under the same degree of weight excess. This study evaluated either the GH response to combined GHRH+arginine administration and the fat body mass, by dual energy X-ray a...

ea0016p390 | Neuroendocrinology | ECE2008

Cardiovascular risk factors in adult onset growth hormone deficiency (AO-GHD) without growth hormone replacement: follow-up period seven years

Djurdjevic Sandra Pekic , Doknic Mirjana , Miljic Dragana , Djurovic Marina Nikolic , Stojanovic Marko , Popovic Vera

Patients with hypopitutarism have higher cardiovascular morbidity and mortality rates than general population, as manifested by elevated fasting lipids and insulin resistance. The aim of our study was to evaluate the lipid levels and insulin responses during oral glucose tolerance test (OGTT) in adult onset growth hormone deficiency (AO-GHD), without growth hormone replacement during a follow-up period of seven years. Ten hypopituitary patients with operated non-functioning pi...

ea0016p391 | Neuroendocrinology | ECE2008

Nocturnal HPA axis activity is blunted by increased plasma glucose concentrations

Benedict Christian , Hallschmid Manfred , Kern Werner , Schultes Bernd , Lehnert Hendrik , Born Jan

Background: Secretory activity of the hypothalamo-pituitary–adrenal (HPA) axis typically increases during the second half of nocturnal sleep. Assuming that this rise in ACTH and cortisol levels occurs in response to the negative energy balance induced by nocturnal fasting and concomitant increases in cerebral glucose consumption during REM sleep, we examined the effects of glucose infusion on nocturnal HPA axis activity during wake and sleep periods.<p class="abstext"...

ea0016p392 | Neuroendocrinology | ECE2008

Macroprolactinemia seems to have a positive effect on platelet activation through ADP stimulation

Anaforoglu Inan , Ertorer Eda , Kozanoglu Ilknur , Unal Birsel , Haydardedeoglu Filiz , Tutuncu Neslihan Bascil , Demirag Nilgun Guvener

Objective: Platelet activation is a recently recognized characteristic of prolactin, which functions through the potentiation of ADP-induced P-selectin expression on platelets. Studies in hyperprolactinemic patients demonstrated atherosclerotic disorders related to insulin resistance; convenient milieus for platelet activation. To investigate the association between hyperprolactinemia and platelet activation related to P-selectin expression, we studied on hyperprolactinemic an...

ea0016p393 | Neuroendocrinology | ECE2008

A study of the serotoninergic tone in healthy subjects and diabetic patients treated by a clinical-paedagogic approach (Group Care) or traditional care

Trento Marina , Tibaldi Paola , Balbo Marcella , Kucich Claudia , Basile Margherita , Borgo Enrica , Tomelini Michela , Passera Pietro , Giordano Roberta , Arvat Emanuela , Cavallo Franco , Porta Massimo

Background and aims: Alterations of mood and depression may be associated with type 2 diabetes (T2DM) and impaired glucose metabolism in non-diabetic people. Central serotoninergic activity may modulate glucose tolerance via neuroendocrine effectors. The serotoninergic tone was assessed by measuring the hormonal response to a selective serotonin reuptake inhibitor, citalopram, in non-diabetic subjects and patients with T2DM followed by either a traditional approach or a clinic...

ea0016p394 | Neuroendocrinology | ECE2008

Growth hormone (GH) treatment on atherosclerosis: results of a 5 years open, prospective, controlled study in male patients with severe GH deficiency

Colao Annamaria , Di Somma Carolina , Spiezia Stefano , Savastano Silvia , Rota Francesca , Savanelli Maria Cristina , D'Andrea Marianna , Lombardi Gaetano

Background: Severe GH deficiency (GHD) is associated with, increased cardiovascular (CV) risk and intima-media thickness (IMT) at major arteries.Objective: To investigate the long-term (5-years) effects of GH replacement on insulin resistance (IR) syndrome (IRS) (at least two of: triglycerides levels ≥1.7 mmol/l, HDL-cholesterol levels ≤1.0 mmol/l, blood pressure above 130/85 mmHg, fasting glucose 6.1–7 or 2 h after glucose 7.7–11.1...

ea0016p395 | Neuroendocrinology | ECE2008

Dopamine receptor expression and dopamine agonist effectiveness in corticotroph pituitary tumors: comparison with clinical, biochemical radiological and pathological features of patients with Cushing's disease

Pivonello Rosario , de Herder Wouter W , Ferone Diego , Kros Johan M , De Caro Maria Laura Del Basso , Lombardi Gaetano , Colao Annamaria , Hofland Leo J , Lamberts Steven WJ

Dopamine receptors (DR) are expressed in the majority of corticotroph pituitary tumors and the dopamine agonist cabergoline is effective in controlling cortisol hypersecretion in around 50% of patients with Cushing’s disease (CD). In order to characterize the tumors expressing D2 receptors and the profile of patients which might respond to the treatment with D2 agonists, the current study has the aim to correlate D2 receptor expression and...

ea0016p396 | Neuroendocrinology | ECE2008

The effects of growth hormone deficiency following moderate and severe traumatic brain injury on cognitive functions

Stojanovic Marko , Pekic Sandra , Pavlovic Dragan , Zivkovic Vladimir , Djurovic Branko , Jovanovic Vladimir , Medic-Stojanoska Milica , Doknic Mirjana , Miljic Dragana , Djurovic Marina , Dieguez Carlos , Casanueva Felipe , Popovic Vera

Hypopituitarism, in particular growth hormone (GH) deficiency, is common among survivors of traumatic brain injury (TBI). We investigated neurobehavioral consequences of TBI-induced GH deficiency (GHD) in 61 patients (aged 37.7±1.7 years, 44 male/17 female) at least one year (mean, 3.9±0.6 years) after moderate and severe TBI (mean GCS score 10.6). All patients were tested with standard neuropsychological battery (MMSE, TMT, RAVLT, RCF, BNT and WCST for executive cog...

ea0016p397 | Neuroendocrinology | ECE2008

Pharmacological prevention of long-term neuroendocrine and behavioral changes in prenatally stressed rats

Reznikov Alexander , Nosenko Nadezhda , Tarasenko Larisa , Sinitsyn Petr

Maternal stress modifies fetal programming of neuroendocrine development and behavior. These effects are mediated by maternal and fetal corticosteroids and opioids. We evaluated an ability of pharmacological prevention of long-term behavioral and hypothalamic–pituitary–adrenal (HPA) disorders in adult rat offspring induced by daily 1 h maternal immobilization during the last gestational week. Dexamethasone (Dex; 0.1 mg/kg per day) or naltrexone (Ntx; 10 mg/kg per day...

ea0016p398 | Neuroendocrinology | ECE2008

Genetic and clinical analyses in an Italian series of idiopathic hypogonadotropic hypogonadism

Bonomi Marco , Antonica Francesco , Cariboni Anna , Busnelli Marta , Pia Anna , Borretta Giorgio , Beck-Peccoz Paolo , Krausz Csilla , Maggi Roberto , Persani Luca

Idiopathic hypogonadotropic hypogonadism (IHH) is a rare and heterogeneous disease due to defects of GnRH secretion or action. IHH could be associated or not with anosmia respectively identifying the Kallmann’s syndrome (KS) or the normosmic IHH (nIHH). So far numerous causative genetic defects have been described, but very recent molecular genetic studies and animal models have opened novel perspectives. We are studying a series of 16 KS (14M,2F) and 18 nIHH (14M,4F). Al...

ea0016p399 | Neuroendocrinology | ECE2008

Four years of growth hormone (GH) therapy improves markers of cardiovascular risk in GH deficient (GHD) survivors of childhood acute lymphoblastic leukaemia (ALL)

Follin Cecilia , Erfurth Eva Marie

Survivors of childhood (CO) ALL treated with prophylactic cranial radiotherapy (CRT) often exhibit (GHD) and increased cardiovascular risk. The aim of this study was to evaluate the effect of 4 years of GH therapy on cardiovascular risk factors in 16 former ALL patients and to compare them with matched population controls after 4 years.Sixteen former CO ALL patients (women=8), aged 24–37 years, treated with CRT (18–24 Gy) and chemotherapy with ...

ea0016p400 | Neuroendocrinology | ECE2008

Impaired microvascular reactivity and endothelial function in patients with Cushing's syndrome

Durovcova Viktoria , Prazny Martin , Jezkova Jana , Horova Eva , Hana Vaclav , Kvasnicka Jan , Pecen Ladislav , Marek Josef , Skrha Jan , Krsek Michal

It is well known that hypercortisolism is associated with increased morbidity and mortality caused predominantly by vascular and atherosclerotic complications. The effect of hypercortisolism on microvasculature is less known. The aim of this study was to evaluate skin microvascular reactivity (MVR) in relation to arterial hypertension, diabetes mellitus and other possible influencing factors (fibrinolysis, oxidative stress and endothelial function) in patients with Cushing&#14...

ea0016p401 | Neuroendocrinology | ECE2008

Serum and glucocorticoid-induced kinase 1 mediates basal and stimulated POMC transcription in pituitary corticotrophs

Helene Reiter Marie , Vila Greisa , Luger Anton

Cushing’s tumours are ACTH-producing neoplasms of the pituitary gland. Their ACTH-oversecretion is autonomous and does not respond to the canonical inhibition of the hence also elevated cortisol. Current research in identifying new drug targets is mainly focused on designing therapeuticals that directly inhibit ACTH over-secretion from the adenoma. Serum and glucocorticoid-induced kinase 1 (Sgk1) is an early target gene of glucocorticoids in all cells studied. It is a PKB...

ea0016p402 | Neuroendocrinology | ECE2008

Effect of hyperprolactinemia in male patients consulting for sexual dysfunction

Giovanni Corona , Mannuci Edoardo , Fisher Alessandra , Lotti Francesco , Ricca Valdo , Balercia Giancarlo , Petrone Luisa , Forti Gianni , Maggi Mario

Objectives: The physiological role of prolactin in male sexual function has not been completely clarified. Aim of this study is the assessment of clinical features and of conditions associated with hyperprolactinemia in male patients consulting for sexual dysfunction.Design and methods: A consecutive series of 2146 (mean age 52.2±12.8 years) male patients with sexual dysfunction was studied. Several hormonal and biochemical parameters were studied a...

ea0016p403 | Neuroendocrinology | ECE2008

Effects of 6 months growth hormone treatment in GH deficient patients (GHD) long after traumatic brain injury (TBI)

Yollin Edwige , Kozlowski Odile , Fontaine Pierre , Rousseaux Marc , Cortet-Rudelli Christine

We studied 84 patients with neuropsychological disabilities at least 1 year after TBI. 24 patients had severe GHD (29%). The aim of this study was to evaluate the effects of six months GH treatment on quality of life and metabolism in this group.GH treatment was initiated in 17 patients (71%), planned with 3, declined by one, contra-indicated in 2, 1 patient moved. It lasted more 6 months in 16 of them (14 men, mean age 36±12, mean delay after TBI 7...

ea0016p404 | Neuroendocrinology | ECE2008

Total and cause-specific mortality in patients from the KIMS database: direct evidence for a beneficial effect of GH replacement therapy on mortality in adult GH deficient patients

Mattsson Anders , Koltowska-Haggstrom Maria , Saller Bernhard , Wilton Patrick , Gaillard Rolf

Growth hormone (GH) replacement in adults with severe GH deficiency (GHD) has well established beneficial effects on the cardiovascular risk profile. Whether this is associated with reduced mortality is still unclear. The present study addresses this question by analysing mortality data in KIMS (Pfizer international metabolic database) and is based on 9610 patients (47% females), accumulating 37882 patient-years of follow-up. There were 257 recorded deaths against 255.1 expect...

ea0016p405 | Neuroendocrinology | ECE2008

Performance characteristics of serum and salivary hormone quantification for luteal phase confirmation in behavioural studies

Brandhorst Gunnar , Behrens Kathrin , Hinrichs Sophie , Jordan Kirsten , Oellerich Michael , von Ahsen Nicolas

Objective: To investigate gender differences in spatial orientation and verbal memory we conducted a study in 21 healthy young women and men (eleven women). Participating women were required to be in the mid-luteal phase of the cycle. Hormone profiling for behavioural studies is often performed in saliva samples to avoid venous blood sampling. We have compared simultaneously collected blood and saliva samples to confirm the presence of the luteal phase.M...

ea0016p406 | Neuroendocrinology | ECE2008

Malignant diseases in our patients with acromegaly

Moya Chimenti Elisa , Alvarez Escola Cristina , Lecumberri Santamaria Beatriz , Fernandez Alberto , Garcia Dominguez Maria , Felipe Pallardo Sanchez Luis

Background: Acromegaly, a chronic disease caused by excess secretion of growth hormone (GH), has been known to reduce patients life expectancy. This increase in morbility and mortality is not only due to cardiovascular, respiratory or cerebrovascular disorders, but also to an increased risk for cancer.Subjects and methods: The aim of this study was to describe the associated malignant diseases among our fifty acromegalic patients. Clinical features of th...

ea0016p407 | Neuroendocrinology | ECE2008

Pituitary abscess: a case report

Darczuk Andrzej , Trofimiuk Malgorzata , Gil Justyna , Hubalewska-Dydejczyk Alicja , Mnich Wlodzimierz , Adamek Dariusz

Pituitary abscess is a very rare entity, only 200 cases (mostly the complication of the pituitary surgery) has been described so far.We want to present the case of pituitary abscess arising from Rathke’s cyst.Case report: Seventy-years-old female treated due to clinical depression, was admitted to the Endocrinology Department because of profound hyponatremia (serum Natrium 119 mmol/l). She was diagnosed with plurihormonal ante...

ea0016p408 | Neuroendocrinology | ECE2008

Effects of weight gain on serum adiponectin, leptin and ghrelin concentrations in patients with anorexia nervosa

Kubat Uzum Ayse , Yucel Basak , Omer Beyhan , Colak Ozbey Nese

Objective: The aim of this study is to determine serum concentrations of adiponectin (ApN), leptin and ghrelin in different stages of anorexia nervosa (AN) and to evaluate their relationships between biochemical, hormonal and anthropometric parameters.Materials and methods: The study is composed of four groups. Group 1: Treatment-naïve patients with a recent diagnosis of AN (n: 19), Group 2: The weight recovered (10% increase in body weight c...

ea0016p409 | Neuroendocrinology | ECE2008

Evaluation of verbal memory function in acromegalic patients treated with or without conventional radiotherapy after transsphenoidal surgery

Lecumberri Beatriz , Estrada Javier , Garcia-Uria Jose , Pallardo Luis Felipe , Lucas Tomas

The impairment of cognitive function found in patients treated for pituitary adenomas has been associated with the effects of conventional radiotherapy (CR). Our aim was to compare the results of an examination of verbal memory function in acromegalic patients treated with transsphenoidal surgery (TS) alone to those obtained from patients treated with TS followed by CR. We retrospectively compared these two outcome groups and carried out a story recall test that included free ...

ea0016p410 | Neuroendocrinology | ECE2008

The role of inferior petrosal sinus sampling for ACTH-dependent Cushing's syndrome

Chua Elizabeth , Perera Nimalie , Hetherington Julie

Objective: Inferior petrosal sinus sampling (IPSS) with CRH stimulation is considered the gold standard for the differential diagnosis of ACTH-dependent Cushing’s syndrome. The aim of this study is to evaluate its role in confirmation and lateralisation of a pituitary source in suspected Cushing’s disease (CD).Methodology: Nine patients with CD with indeterminate MRI underwent IPSS from August 2004 to February 2007. Three were being assessed fo...

ea0016p411 | Neuroendocrinology | ECE2008

Comparison of visceral adipose tissue content between diabetic and nondiabetic acromegalic patients

Yesim Tijen , Saler Tayyibe , Ucak Sema , Yenigun Mustafa , Ataoglu Esra , Altuntas Yuksel

Acromegaly is known to be associated with insulin resistance. Visceral adipose tissue is increased in patients with insulin resistance and we aimed to investigate a visceral adipose tissue content as a possible marker of insulin resistance in diabetic and nondiabetic acromegalic patients. We compared 16 diabetic and 16 nondiabetic acromegalic patients for fasting blood glucose (FBG), insulin and visceral adipose tissue content calculated from abdominal computer tomography. All...

ea0016p412 | Neuroendocrinology | ECE2008

A non-functioning pituitary carcinoma with cerebellar metastases

Gavilan Inmaculada , Ortego Jose , Coserria Cristina , Gil Jose , Rodriguez Ana , Japon Miguel , Aguilar Manuel

Pituitary carcinomas are rare but represent a particular challenge to clinical practice. We report a case of pituitary carcinoma with metastatic disease in a separate non-contiguous foci within the central nervous system. A 64 year old man presented with a large non-functioning pituitary adenoma manifesting as headache, third pair of cranial nerves paralysis, panhypopituitarism and impaired visual acuity in 1996.The tumour was grossly removed through a right pterional cranioto...

ea0016p413 | Neuroendocrinology | ECE2008

Impact of hyperglycaemia on carotid intima-media thickness in acromegaly

Saler Tayyibe , Yesim Tijen , Ucak Sema , Yenigun Mustafa , Ataoglu Esra , Kocoglu Hakan , Altuntas Yuksel

Acromegaly is known to be associated with both increased cardiovascular mortality and carbohydrate intolerance. The aim of our study is to compare intima-media thickness, a marker of atherosclerosis in active acromegalic patients with and without diabetes. 32 active acromegalic patients (M/ F: 15/17, 16 diabetic and 16 nondiabetic) were assessed for fasting blood glucose (FBG), insulin, growth hormone, insulin-like growth factor 1 and carotid intima-media thickness (IMT). Diab...

ea0016p414 | Neuroendocrinology | ECE2008

Autoimmune hypophysitis and isolated corticotrophin deficiency

Gentil Alfonso , Martin Tomas , Torres Alberto , Serrano Isabel , Morales Cristobal , Maraver Silvia , Martinez de Pinillos Guiillermo , Garcia-Quiros Juan Manuel , Sendon Angel

Introduction: Isolated ACTH failure is a rare disorder characterized by a secondary adrenal failure and a considerable deterioration of the general state. In adults the has been established related to cranial traumatism and to autoimmune hypophysitis (AH). It has been pointed out that the isolated failure of pituitary tropin in the context of a AH, could end with a global pituitary failure.Objective: Evaluation of the shortage of isolated ACTH as a way o...

ea0016p415 | Neuroendocrinology | ECE2008

Heel pad thickness in diabetic and nondiabetic acromegalic patients

Saler Tayyibe , Yesim Tijen , Ucak Sema , Yenigun Mustafa , Ataoglu Esra , Kocoglu Hakan , Altuntas Yuksel

Increased heel pad thickness can be used as a marker of soft tissue enlargement in acromegalic patients. We aimed to investigate if concomittant hyperinsulinemia/and or diabetes secondary to insulin resistance in acromegaly contribute to the enlargement of heel pad. We compared heel pad thickness in 16 diabetic and 16 nondiabetic active acromegalic patients using X-ray images. All of the diabetics were well controlled with diet and/ or oral antidiabetic drugs. GH and IGF-1 wer...

ea0016p416 | Neuroendocrinology | ECE2008

Perioperative steroid treatment is not routinely required in endoscopic transphenoidal surgery for clinically non functioning pituitary adenomas (NFPA)

Cozzi Renato , Lasio Giovanni , Felisati Giovanni , Attanasio Roberto

Steroids are still widely prescribed in pituitary trans-sphenoidal surgery (TSA). Pituitary-adrenal/thyroid/gonadal functions were prospectively evaluated in 72 consecutive NFPA pts (20–87 years, 37 M) before and after endoscopic-TSA (E-TSA) (63 at first operation, 9 at re-operation). All had macroadenoma with suprasellar extension: impinging optic chiasma in 28, extending into cavernous sinus (CS) in 23, giant in 12. Hydrocortisone was infused peri-operatively only in pt...

ea0016p417 | Neuroendocrinology | ECE2008

Pituitary deficiencies after autologous bone marrow transplantation

Lesven Sandra , Josseaume Claire , Dolz Manuel , Sonnet Emmanuel , Roudaut Nathalie , Berthou Christian , Kerlan Veronique

Development in autologous bone marrrow transplantation (auto-BMT) has improved survival, but new endocrine complications now emerge. If primary thyroid and gonadal deficiencies are documented in medical literature, pituitary deficiencies are less well-known, especially in adults. The aim of the study was to investigate pituitary function in patients who survived at least one year after transplantation for malignant haematologic disorders by a prospective study.<p class="ab...

ea0016p418 | Neuroendocrinology | ECE2008

Consequences of isolation stress on glucocorticoid regulating genes and behavioural response in postnatal pigs

Kanitz Ellen , Puppe Birger , Tuchscherer Margret , Viergutz Torsten , Tuchscherer Armin , Blank Theresa

Early life events can have short and long-term effects on neuroendocrine, autonomic, and behavioural responses to stress and appear to play an important role in the etiology of stress-related disorders. Glucocorticoids are thought to be key mediators of these brain-endocrine-immune connections. We investigated the effects of a short-term social isolation (4 h) of domestic piglets at different days of age (7, 21, 35) both on behavioural alterations in open-field tests and on mo...

ea0016p419 | Neuroendocrinology | ECE2008

Demography, characteristics and outcome of acromegaly at King Hussein medical centre amman Jordan

Malkawi Omar , Haddad Fares , Omari Ahmad , Sharbaji Amer , Izzat Alia , Khawaldeh Abdelkarim , Qadah Reem , Aleyadeh Abdullah , Srehein Khaldon

Acromegaly is a chronic debilitating disease due to long term exposure to elevated levels of growth hormone (GH) which leads to excessive growth of both skeletal and soft tissues. It is slowly progressive with 30% increase in mortality rate for cardiovascular disease, respiratory complications and malignancies. The estimated prevalence of the disease is 40 cases per million with 3–4 new cases per million populations per year. Acromegaly most commonly presents between the ...

ea0016p420 | Neuroendocrinology | ECE2008

Sleep quality in patients of a primary health care unit and its relationships with antropometric parametters

Penalva Angela , Lichtenstein Gretel , Cadarso Carmen

Objective: To study the sleep quality in patients of a primary health care unit and Its relationship with anthropometric parameters as sex, age, BMI and waist circumference.Participants and methods: One hundred and twenty-two patients arrived spontaneously and correlatively for consultation. The Pittsburgh sleep quality index questionnaire (PQ5I) was used to investigate the patients sleep quality in the last month. The PQ5I explores seven aspects: C1) su...

ea0016p421 | Neuroendocrinology | ECE2008

Glucose-dependent insulinotropic polypeptide receptor (GIPR) in human pituitary adenomas

Occhi Gianluca , Losa Marco , Albiger Nora , Scanarini Massimo , Del Verme Jacopo , Mantero Franco , Scaroni Carla

Glucose-dependent insulinotropic polypeptide (GIP) receptor is a member of the G protein-coupled receptors family. According to its incretin properties, GIPR is expressed in tissues such as pancreas, stomach and adipose tissue. However GIPR expression pattern appears to be broader, as it was detected in other tissues such as heart, lung and the central nervous system, thus suggesting either novel ligands for GIPR or novel actions for GIP. Moreover, in some patients with food-d...

ea0016p422 | Neuroendocrinology | ECE2008

Macroprolactinaemia in men

Dzeranova Larisa K , Giniyatullina Ekaterina N , Rozhinskaya Ludmila Y , Goncharov Nikolai P , Dobracheva Anna D

Background: It is known women suffer from macroprolactinaemia more frequently than men. Often men with unclear genesis of hyperprolactinaemia have normal or a little depressed Testosterone level. High macroprolactin level in blood serum can explain this type of hyperprolactinaemia.Materials and methods: Sixty-four men with hyperprolactinaemia (Prl >600 mU/l) were studied. Clinical, biochemical and MRI methods were used. Prl and Testosterone levels we...

ea0016p423 | Neuroendocrinology | ECE2008

Age-dependent expression of ret receptor from perinatal life to adulthood

Garcia-Lavandeira Montserrat , Diaz-Rodriguez Esther , Dieguez Gonzalez Carlos , Alvarez Villamarin Clara

The RET/GFRa/GDNF system displays a wide distribution in tissues such as nervous system, kidneys, intestine or testis. RET has been implicated in human pathologies. RET is a tyrosine-kinase receptor activated by four ligands GDNF, NTN, ART and PSPN through four co-receptors GFRa1, 2, 3 and 4 respectively. Activation of the receptor leads to cell differentiation or proliferation. Our group has shown that RET is expressed specifically in the somatotrope (GH) adult cell populatio...

ea0016p424 | Neuroendocrinology | ECE2008

Midnight salivary cortisol (MSC) to assess the outcome of transsphenoidal surgery (TSS) in Cushing's disease (CD)

Carrasco Carmen , Coste Joel , Guignat Laurence , Dugue Marie-Annick , Gaillard Stephane , Bertagna Xavier , Bertherat Jerome

Introduction: MSC is a simple and reliable mean to diagnose hypercortisolism, yet its value to asses the outcome of treatment has rarely been addressed.Objective: Compare MSC and other classical parameters, to assess the outcome of TSS in CD.Patients and methods: Sixty-eight patients from a single Center operated for CD between 1996 and 2006. Outcome was assessed between 6–12 months post TSS. Remission was defined as: morning ...

ea0016p425 | Neuroendocrinology | ECE2008

Tests of growth hormone (GH) status in severe GH deficiency: do they identify a similar phenotype? Insight from the KIMS database

Toogood Andrew , Brabant George , Buchfelder Michael , Feldt-Rasmussen Ulla , Koltowska-Haggstrom Maria , Jonsson Bjorn , Krogh Rasmussen AEse , Maiter Dominique , Saller Bernhard , Biller Beverly

A GH peak of 3 μg/l during the insulin tolerance test (ITT) is considered the gold standard for identifying adults with severe GH deficiency. Alternative stimuli such as arginine (AST) and glucagon (GST) are also employed but produce lower GH peaks than the ITT in normal subjects. Despite this, 3 μg/l is used as the diagnostic threshold for these tests, raising the possibility that severe GH deficiency is being diagnosed inappropriately.We stud...

ea0016p426 | Neuroendocrinology | ECE2008

Enos, P22phox and apoE gene polymorphism associations with circulating hormone levels in the elderly

Ianas Olga , Manda Dana , Heltianu Constantina , Sima Anca , Raicu Monica , Covic Marcela , Dumitrache Constantin

Objective: The aim of this study was the identification of eNOS (G894T), p22phox (−930 A/G) and apoE gene polymorphisms associated with the impact of age-dependent endocrine changes.Subjects and methods: Subjects, both genders, were recruited and classified into the three groups: (1) 100 subjects aged 55–80+ years with mild cognitive impairment (MCI) (MMSE<28); (2) 165 age-matched subjects without cognitive impairment (MMSE>...

ea0016p427 | Neuroendocrinology | ECE2008

Is increase in bone mineral content caused by increase in skeletal muscle mass/strength in adult patients with growth hormone (GH) treated GH deficiency? A litterature analysis

Klefter Oliver Niels , Feldt-Rasmussen Ulla

Growth hormone (GH) has a well known anabolic effect on skeletal muscles, and patients with GH deficiency (GHD) are characterised by a reduced muscle mass, but also reduced bone mineral density (BMD) and content (BMC), which have been ascribed to GHD per se. Correspondingly, the increase in bone and muscle mass by GH therapy has been seen as separate GH influences on bones and muscles, respectively. The aim of this study was therefore to investigate if changes in BMD/BM...

ea0016p428 | Neuroendocrinology | ECE2008

Neuroendocrine effects of citalopram, a selective serotonin re-uptake inhibitor (SSRI), during lifespan in humans

Berardelli Rita , Margarito Enrica , Ghiggia Federica , Picu Andreea , Bonelli Lorenza , Balbo Marcella , Giordano Roberta , Bo Mario , Arvat Emanuela

Central serotoninergic activity (CSA) is known to influence the hypothalamus–pituitary–adrenal (HPA) axis, and a CSA loss seems to play a role in human brain aging and in etiology of functional hypercortisolism and depression, whose incidence increase with advancing age. Citalopram (CT), a SSRI, has been considered a good tool to evaluate CSA in humans. Aim of this study was to evaluate the neuroendocrine response to CT in healthy adult subjects during lifespan. We e...

ea0016p429 | Neuroendocrinology | ECE2008

Variable effects of preproTRH(178–199) on ACTH secretion by human corticotrope tumors

Giraldi Francesca Pecori , Pesce Samantha , Maroni Paola , Losa Marco , Cavagnini Francesco

PreproTRH (178–199), a 22-aminoacid cleavage product of the TRH prohormone, has been postulated to act as an ACTH-releasing inhibitor. Indeed, in vitro evidence indicates that this peptide may inhibit basal and stimulated ACTH secretion in rodent anterior pituitary primary cultures and cell lines (Redei 1995, Revskoy 2001), although not all studies concur (Nicholson 1996). Aim of the present study was to test the effect of preproTRH(178–199) in human tumoral c...

ea0016p430 | Neuroendocrinology | ECE2008

Endocrine features of aging and cognitive function in women

Manda Dana , Vladoiu Suzana , Rosca Roxana , Joja Oltea , Trifu-Iordachescu Carmen , Covic Marcela , Halici Florentina , Ianas Olga

Objective: An on-going epidemiological populational study examined hormone balance during aging in women, and – whether there was a difference in endogenous serum sex hormone levels between a postmenopausal women group with moderately cognitive impairment and healthy age-mached women group.Subjects and methods: One hundred and sixty-three women aged 25 to 80 years were classified into three groups: (1) 44 subjects aged 55–80 years with moderate...

ea0016p431 | Neuroendocrinology | ECE2008

Effect of a six-month treatment with octreotide long acting repeatable (LAR) on mean platelet volume in patients with acromegaly

Ersoy Reyhan , Gul Kamile , Solaroglu Ihsan , Dirikoc Ahmet , Aydin Cevdet , Soydal Cigdem , Cakir Bekir

Objective: Mean platelet volume (MPV), is an indicator of platelet sizes, and an indirect marker of platelet function and activity. In this study, we aimed to evaluate MPV in patients with acromegaly, and to investigate the effects of octreotide long acting repeatable (LAR) on MPV after 6-month therapy.Methods: Data of 25 patients with acromegaly (16 women; 9 men; mean age, 43.8±13.5 years) included in the study were searched retrospectively. The da...

ea0016p432 | Neuroendocrinology | ECE2008

GHRH as a possible allosteric ligand of the ghrelin receptor GHS-R1a

Carreira Marcos C , Camina Jesus P , Lage Mary , Casanueva Felipe F

Ghrelin and GHRH are two hormones involved in the growth hormone (GH) secretion through their respective receptors. The growth hormone secretagogue receptor subtype 1a (GHS-R1a) is involved in biological actions exerted by ghrelin triggering intracellular second messengers coupled to Gαq/11 protein. In this work, we analyzed the possible interaction between GHRH and GHS-R1a as well as the subsequent intracellular pathways. The results showed that GHRH induced, ...

ea0016p433 | Neuroendocrinology | ECE2008

Unusual pattern of pituitary insufficiencies following traumatic brain injury evaluated by insulin tolerance test

Faust Michael , Wille Julia , Schumann Christina , Lippert-Gruener Marcela , Ernestus Ralf I , Krone Wilhelm

There is growing evidence that pituitary failure is a common complication of traumatic brain injury. However, prevalence of hypopituitarism following traumatic brain injury varies between 25 and 69% in the literature. Moreover, the pattern of involved hypothalamic/pituitary axes differs considerably in the published trials. This might be due to small and inhomogeneous series of patients and different test methods in previous studies. The aim of our study was therefore to inves...

ea0016p434 | Neuroendocrinology | ECE2008

Hypopituitarism and features of the metabolic syndrome in patients with traumatic brain injury (TBI)

Prodam Flavia , Gasco Valentina , Rovere Silvia , Perino Claudio , Golisano Graziella , Busti Arianna , Belcastro Sara , Corneli Ginevra , Aimaretti Gianluca

Objective: Hypopituitarism in adults may be a consequence of TBI, but in the acute or long term management of TBI patients (ptx), endocrine evaluations are not usually included. Aim of this study was to investigate the prevalence of hypopituitarism and metabolic syndrome in a population of 54 severe (n=31) and moderate (n=23) TBI ptx (38 M, 16 F; age (mean±S.D.): 39.8±2.1 years) who had TBI more than 12 months before.<p class="abstext...

ea0016p435 | Neuroendocrinology | ECE2008

Lymphocytic infundibulo-neurohypophysitis with diabetes insipidus and favorable evolution after glucocorticoid treatment

Ungureanu Maria-Christina , Luca Ioana , Grigoras Mihai , Gorduza Carmen , Vulpoi Carmen , Zbranca Eusecie

Infundibulohypophysitis is an unusual inflammatory condition that affects the infundibulum, the pituitary stalk and the neurohypophisis and may be a part of a range that includes lymphocityc hypophysitis. It occurs mainly in women and most often presents in later stages of pregnancy. Infundibilohypophysitis usually presents with diabetes insipidus. The case of a 30-year-old woman with diabetus insipidus diagnosticated in the third trimester of the pregnancy is reported. She wa...

ea0016p436 | Neuroendocrinology | ECE2008

Prolactin levels in patients with cirrhosis increase with severity of liver disease

Payer Juraj , Koller Tomas , Baqi Lahim , Kollerova Jana

Background: Pituitary prolactin secretion is physiologically supressed by dopaminergic tonus from hypothalamus, which itself is under regulation by various hypothalamic releasing factors. We Disturbed dopaminergic tonus in patients with liver cirrhosis is suspected.The aim of our study was to measure prolactin levels in patients with cirrhosis and to investigate the relatioship between the severity of liver disease and other clinical and laboratory param...

ea0016p437 | Neuroendocrinology | ECE2008

Pituitary dysfunction in patients after stroke

Boehncke Sandra , Fischer Kathrin , Badenhoop Klaus , Sitzer Matthias

Hypopituitarism is a known complication of traumatic brain injury and subarachnoidal bleeding. There are few data about pituitary dysfunction as a complication of cerebral ischemia. This study aimed to investigate this issue. We investigated the prevalence of pituitary dysfunction in patients with cerebral ischemia (a. cerebri media: n=19, thalamus: n=4 multiinfarction syndrome: n=17) NIHSS varied between 1–8. 40 patients, 23 males and 17 females, (me...

ea0016p438 | Neuroendocrinology | ECE2008

Abstract withdrawn...

ea0016p439 | Neuroendocrinology | ECE2008

A comparison between three automated chemiluminescence assays for growth hormone: on the use of recombinant hGH as a primary calibrant

Arafat Ayman M , Mohlig Matthias , Weickert Martin O , Perschel Frank H , Purschwitz Johannes , Spranger Joachim , Strasburger Christian J , Schofl Christof , Pfeiffer Andreas FH

Objectives: GH measurements during OGTT have profound effects on therapy and follow-up management of acromegaly. To minimize the discordance between immunoassays, it is recommended to calibrate them using 22 kDa-GH-preparation instead of the use of pituitary-derived calibrants. The aim of our study was to evaluate the between-method discrepancies in GH determinations by assays using different calibrants considering further confounders like age, gender, and BMI.<p class="ab...

ea0016p440 | Neuroendocrinology | ECE2008

Acute effects of the intranasal administration of growth hormone-releasing hormone (GHRH) on nocturnal memory consolidation in waking young men

Hallschmid Manfred , Wilhelm Ines , Michel Christian , Born Jan , Lehnert Hendrik , Perras Boris

Introduction: The activity of the somatotropic system displays a secretory maximum during early sleep which is also a period known to be important for memory consolidation. Blocking of the sleep-onset associated GH-surge by somatostatin did not affect memory performance but the contribution of growth hormone-releasing hormone (GHRH) to memory processes is unclear. Here we assessed the influence of intranasal GHRH on memory function in waking subjects during the early part of t...

ea0016p441 | Neuroendocrinology | ECE2008

Cardiovascular risk profile in 81 acromegalic patients: a cross-sectional clinical study

Dimopoulou Christina , Sievers Caroline , Schneider Harald , Rommler Josefine , Schopohl Jochen , Stalla Gunter Karl

Objectives: Acromegaly is associated with elevated cardiovascular morbidity. Medical treatment of acromegaly does not only lead to a normalisation of the somatotroph axis, but can also negatively influence cardiovascular risk factors and comorbidities.Methods: In a cross-sectional study, we evaluated cardiovascular risk markers (glucose, HbA1c, triglycerides, cholesterol, HDL, LDL, lipoprotein a, homocystein, CRP) in relation to biochemical control and m...

ea0016p442 | Neuroendocrinology | ECE2008

Diurnal cortisol profile changes in the acute phase after aneurysmal subarachnoid hemorrhage

Poll Eva Maria , Bostrom Azize , Burgel Uli , Gilsbach Joachim Michael , Kreitschmann-Andermahr Ilonka

Cortisol dynamics have been found to be disturbed in acute illness. Despite reports on neuroendocrine disturbances after aneurysmal subarachnoid hemorrhage (SAH), data on cortisol dynamics in the acute phase of this illness are lacking. We evaluated diurnal cortisol rhythm in n=25 patients 1 week (t1) and 2–3 weeks (t2) after SAH. The study was approved by the local ethics committee. Cortisol and CBG were measured in serum, blood samples were drawn a...

ea0016p443 | Neuroendocrinology | ECE2008

Pregnancy in the rat is a physiological state of leptin resistance

Trujillo-G Martha L , Casas-A Luz , Dieguez-G Carlos , Rosa Senaris R

Pregnancy is a state of physiological hyperphagia and represents a good model to unravel the mechanisms involved in feeding regulation. The hyperphagia is the main responsible for the positive energy balance in gestation, which is necessary for maintaining maternal energy stores. The presence of high serum leptin levels and hyperphagia during pregnancy is a paradoxical event and reflects a state of leptin resistance. In order to evaluate the mechanisms for hypothalamic leptin ...

ea0016p444 | Neuroendocrinology | ECE2008

Effects of intranasal atrial natriutetic peptide (ANP) and insulin on sleep-associated pituitary–adrenal inhibition in elderly humans

Hallschmid Manfred , Bendict Christian , Spielmann Sophie , Schicke Rick , Kern Werner , Born Jan , Lehnert Hendrik

Introduction: In elderly humans sleep disturbances are associated with an impaired nocturnal inhibition of the hypothalamo–pituitary–adrenal (HPA) axis and chronic diseases like metabolic syndrome and depression. Recent experiments in young and healthy subjects demonstrated that intranasal ANP inhibited stimulated cortisol secretion during wakefulness whereas administration of intranasal insulin in the evening reduced cortisol levels in the morning after undisturbed ...

ea0016p445 | Neuroendocrinology | ECE2008

Long-term treatment with dopamine agonists is not associated with increased prevalence of valvular heart disease in patients with prolactinomas

Kars Marleen , Delgado Victoria , Holman Eduard , Feelders Richard , Smit Jan , Romijn Hans , Bax Jeroen , Pereira Alberto

Objective: Treatment with ergot-derived dopamine agonists, pergolide and cabergoline, has been associated with an increased frequency of valvular heart disease in Parkinson’s disease. The aim of the present study was to assess the prevalence of valvular heart disease in patients treated with dopamine agonists for prolactinomas.Design: Cross-sectional study.Patients: We performed conventional two-dimensional and Doppler echocar...

ea0016p446 | Neuroendocrinology | ECE2008

Expansion of grey and white matter volumes and increased white matter gliosis in acromegaly: a clinicoradiological study of 43 patients

Sievers Caroline , Samann Philipp , Dose Tatjana , Czisch Michael , Dimopoulou Christina , Schneider Harald , Rommler Josefine , Schopohl Jochen , Stalla Gunter Karl

Background: In acromegaly, few in vivo data exist on changes of the brain parenchyma as a pathology caused by systemically elevated levels of GH and IGF-1. This is in contrast to neuropsychiatric symptoms such as depression, cognitive impairment, personality changes and pain syndromes that accompany the condition. We aimed at measuring brain tissue volumes and white matter pathology in acromegaly.Methods: Forty-three patients (age 54±14 years...

ea0016p447 | Neuroendocrinology | ECE2008

GH response to GH-releasing hormone–arginine (GHRH+Arg) is impaired in women affected by human immunodeficiency virus (HIV)-related lipodystrophy

Rochira Vincenzo , Zirilli Lucia , Orlando Gabriella , Scaltriti Sara , Squillace Nicola , Diazzi Chiara , Esposito Roberto , Carani Cesare , Guaraldi Giovanni

Context: Lipodystrophic HIV patients frequently display impaired pituitary GH response. Objective. To investigate the GH response to GHRH+Arg in women with HIV-related lipodystrophy (HARS) compared with healthy females. To identify possible predictive factors for such a GH response in these patients.Patients: Forty-nine female patients with HARS were compared with 10 healthy women matched for age and BMI.Methods: Patients and contr...

ea0016p448 | Neuroendocrinology | ECE2008

Glucose infusion affects memory function but not ACTH concentrations in patients with Addison's disease

Kuehn Johanna , Hubold Christian , Loeck Cecilia , Oltmanns Kerstin M , Peters Achim

Background: Sucrose intake has been shown to normalize the disturbed neuroendocrine stress response in adrenalectomized rats. These previous data indicate a compensatory effect of energy supply on altered parameters in chronic cortisol deficiency. Thus, we hypothesized that glucose infusion may have similar beneficial effects in patients with Addison’s disease.Methods: We examined 10 patients with primary adrenal insufficiency who discontinued their...

ea0016p449 | Neuroendocrinology | ECE2008

Prevalence of metabolic syndrome in adult hypopituitaric patients with GH deficiency (GHD)

Di Somma Carolina , Rota Francesca , Tufano Antonella , Rota Francesca , Di Minno Dario Nicola , D'Andrea Marianna , Lombardi Gaetano

The prevalence of the metabolic syndrome is increasing worldwide. The untreated metabolic syndrome places individuals at risk both for diabetes and cardiovascular disease. Adult GH deficiency syndrome present some of the 5 features of the metabolic syndrome, abdominal obesity, high triglycerides, low HDL-cholesterol, elevations of blood glucose, hypertension and a 2-fold higher risk of death for CD compared with controls. The aim of this study was to determine the prevalence o...

ea0016p450 | Neuroendocrinology | ECE2008

The benefit of long-term growth hormone replacement therapy in adults, results of the German KIMS database

Albrecht Christin , Buchfelder Michael , Faszbender Walter , Faust Michael , Kann Peter , Kreitschmann-Andermahr Ilonka , Kohlmann Thomas , Koltowska-Haggstrom Maria , Wallaschofski Henri

Objective: The German KIMS Database is a national surveillance study for evaluation of efficacy and safety of growth hormone (GH) replacement therapy in adults with GH deficiency (GHD) in clinical practice.Patients: The analysis was performed using data of 1425 consecutively documented adult patients (777 men, 648 women) with GHD enrolled in KIMS Germany. The present report examined baseline and long term data (>48 months, range: 48–161 month) f...

ea0016p451 | Neuroendocrinology | ECE2008

Panhypopituitarism due to hemochromatosis: a case report

Ozkaya Mesut , Gisi Kadir , Cetinkaya Ali , Kantarceken Bulent , Cerit Mustafa , Sahin Murat , Koroglu Sedat

Introduction: Hemochromatosis is an iron storage disease characterized by iron deposition in parenchymal cells due to increased intestinal iron absorption. Iron overload leads to tissue damage and dysfunction particularly in the liver, pancreas, heart, joints, and pituitary gland. Panhypopituitarism is a clinical condition in which the anterior pituitary gland hormones are deficient. Herein we report a very rare case of panhypopituitarism due to hemochromatosis.<p class="a...

ea0016p452 | Neuroendocrinology | ECE2008

Pituitary autoantibodies in patients with central diabetes insipidus and polydipsia: evidence of autoimmune pituitary involvement in both states

Pigarova Ekaterina , Rozhinskaya Ludmila , Dzeranova Larisa , Keda Yulia , Morozova Maria , Pankov Yurii

A role of autoimmune aggression is postulated in the pathogenesis of different diseases in endocrinology. Forty to sixty percent of cases of central diabetes insipidus (CDI) are considered to be idiopathic. Primary polydipsy is a diagnosis of an exclusion of diabetes insipidus on the basis of water deprivation test, but sometimes it precedes the overt CDI. Thus the aim of this study was to define the prevalence of pituitary autoantibodies in patients with CDI and primary polyd...

ea0016p453 | Neuroendocrinology | ECE2008

Endocrinopathies with langerhans cell histiocytosis (LCH): nine cases

Yarman Sema , Mert Meral , Salman Serpil , Tanakol Refik , Alagol Faruk

LCH is a rare proliferative histiocytic disorder, and it can infiltrate virtually any site in the body. Diabetes incipidus (DI) is the most common abnormality when there is involvement of the hypothalamic-pituitary axis (HPA). We have evaluated the anterior pituitary function and their responses to treatment in 9 patients (5M/4F; range 19–60 years) with proven LCH and DI. Endocrine evaluations consisted of clinical history, basal (GH, IGF-1, fT4, TSH, PRL, cortisol, LH, F...

ea0016p454 | Neuroendocrinology | ECE2008

Aryl hydrocarbon receptor interacting protein (AIP) expression in human pituitary adenomas

Jaffrain-Rea Marie-Lise , Spilioti Cristina , Vanbellinghen Jean-Francois , Daly Adrian , Gargano Donatella , D'Innocenzo Emanuela , Giangaspero Felice , Tichomirowa Maria , Esposito Vincenzo , Ventura Luca , Naves Luciana , Alesse Edoardo , Beckers Albert

Background: Germline AIP mutations confer a predisposition to pituitary adenomas (PA), usually in the setting of familial isolated pituitary adenomas (FIPA); AIP mutations account for 50% of familial acromegaly. AIP-related PA are GH, PRL-secreting or non-secreting. Little is known about AIP expression in PA. Although the prevalence is low, identifying AIP mutations in apparently sporadic PA is important for studying at-risk relatives. Pre-screening criteria would help select ...

ea0016p455 | Neuroendocrinology | ECE2008

Systemic comorbidities induce early vascular alterations in patients with active acromegaly

Ferrau Francesco , Romanello Giovanni , Squadrito Stefano , Carerj Scipione , Nipote Carmelo , Iudicello Raffaella , Trimarchi Francesco , Cannavo Salvatore

Mortality risk is increased in acromegalics, due to cerebrovascular and cardiovascular events. These events are namely related to atherosclerotic vascular alterations, both at coronary and peripheral level. Systemic comorbidities increase the risk of atherosclerosis, but the role of GH and IGF-1 excess is still debated. To evaluate the relationship between GH/IGF-1 excess, systemic atherogenic complications and vascular alterations we investigated stiffness index (β), pul...

ea0016p456 | Neuroendocrinology | ECE2008

Use of videocapsule endoscopy (VCE) for the detection of small bowel tumors in patients with acromegaly

Coletti Francesca , Lucia Ronchi Cristina , Montefusco Laura , Fesce Edoardo , Ogliari Cristina , Ferrante Emanuele , Epaminonda Paolo , Dolci Alessia , Adda Guido , Beck-Peccoz Paolo , Arosio Maura

A high risk for small bowel (SB) tumors in acromegalic population has been reported in a cohort study (Baris D, 2002). SB lesions may be easily investigated by the recently developed videocapsule endoscopy (VCE). Aim of the study was to assess the prevalence of SB neoplasms by VCE in 14 acromegalic patients (Ac) in respect to 30 sex and age-matched control subjects and to correlate it with cancer risk factors and acromegaly-related parameters. Local Ethical committee approved ...

ea0016p457 | Neuroendocrinology | ECE2008

Fatigue in breast cancer patients during chemotherapy: correlation with neuromuscular dysfunction and IGF-1 plasma levels

Baldelli Roberto , Pietrangeli Alberto , Cigliana Giovanni , Fabi Alessandra , Cognetti Francesco , Pugliese Patrizia , Appetecchia Marialuisa

Introduction: Adult growth hormone deficiency is associated with fatigue, tiredness and myalgias. The same clinical pattern can often be present in oncological patients during chemotherapy and follow up.Aim of the study: To conduct an extensive neuromuscular investigation of patients with breast cancer (BC), treated with taxol, in an attempt to explain their neuromuscular symptoms, eleven pre-menopausal patients with BC underwent a prospective protocol, ...

ea0016p458 | Neuroendocrinology | ECE2008

Effect of GH replacement on coronary flow reserve (CFR) and on some cardiovascular risk factors in adult GHD patients

Boschetti Mara , Agosti Sergio , Albanese Valeria , Casalino Laura , Vera Lara , Goglia Umberto , Paolo Bezante Gian , Ferone Diego , Minuto Francesco

GH deficiency (GHD) negatively influences cardiovascular function directly by impairing cardiac filling, performance, and contractility and indirectly by inducing atherosclerotic changes, hypercoagulability, abdominal obesity, insulin resistance, dislipidemia, endothelial dysfunction, etc. This accounts for the reduced life expectancy and increased risk of death for vascular disease in these patients.CFR represents the capacity of the coronary circulatio...

ea0016p459 | Neuroendocrinology | ECE2008

Effect of cholescytokinin (CCK) on food intake and brainstem and hypothalamic neuronal activation and its modulation by glucocorticoid

Sabino Henrique , Uchoa Ernani , Rorato Rodrigo , Antunes-Rodrigues Jose , Elias Lucila

CCK, secreted from duodenal cells in response to nutrients is involved in the satiety mechanisms, via activation of nucleus tractus solitarius (NTS). The arcuate (ARC) and paraventricular nuclei (PVN), which receives projections from NTS, integrate the circuitry that controls food intake. Corticotrophin releasing factor (CRF) participates in the energy homeostasis, decreasing food intake.To evaluate the effect of glucocorticoid on feeding and neuronal ac...

ea0016p460 | Neuroendocrinology | ECE2008

Intrasellar and parasellar tumors – concomitant symptoms and clinical syndromes

Kurowska Maria , Malicka Joanna , Tarach Jerzy S , Zwolak Agnieszka , Dudzinska Marta , Kowalczyk Mariusz

Introduction: Pituitary gland, sella turcica and parasellar region can be involved by wide variety of lesions. Diagnosis of this pathology demands a multidisciplinary effort, especially endocrinological, ophthalmologic and neurological procedures. Each of these entities has unique diagnostic and treatment considerations.Aim: Review of clinical symptoms related to sellar–parasellar region tumors and documentation of heterogeneity of clinical syndrome...

ea0016p461 | Neuroendocrinology | ECE2008

d3-growth hormone receptor polymorphism (d3-GHR) is associated with low BMI and better glucose metabolism in acromegaly

Arosio Maura , Filopanti Marcello , Montefusco Laura , Olgiati Luca , Lucia Ronchi Cristina , Losa Marco , La Porta Carmen , Coletti Francesca , Lania Andrea , Beck-Peccoz Paolo , Spada Anna

Background: The d3-growth hormone receptor (GHR) polymorphism is a common variant characterized by genomic deletion of exon 3 (d3) of the GHR gene. It could be linked to a better growth response to GH, but the findings are controversial. Due to the lack of IGF-I feedback on the tumoral GH secretion, acromegaly seems to be a good model to study functional characteristics of this polymorphism. Aim of the study was to investigate possible influences of d3-GHR on GH and IGF-I rela...

ea0016p462 | Neuroendocrinology | ECE2008

Correlation of IGF-1 and IGFBP-3 levels with liver function in patients following traumatic brain injury or subarachnoidal haemorrhage

Muller-Offner Alexandra , Gutt Bodo , Bidlingmaier Martin , Knittel Thomas , Siegmund Thorsten , Schumm-Draeger Petra-Maria

The prevalence of growth hormone deficiency (GHD) following traumatic brain injury (TBI) based on IGF-1 testing differs in literature between 10 and 40%. In our cohort the frequency of IGF-1 values <1 S.D. was 25%. If our patients had a minimal hepatocellular damage, the IGF-1 value could be <1 S.D. We evaluated the effects of BMI and liver function on IGF-1 and IGFBP-3 values in patients following TBI or subarachnoidal haemorrhage (SAH).<...

ea0016p463 | Neuroendocrinology | ECE2008

Identification and molecular characterization of new somatostatin receptor subtype 5 truncated isoforms in rodents

Cordoba-Chacon Jose , Luque Raul M , Gahete Manuel D , Duran-Prado Mario , Gracia-Navarro Francisco , Kineman Rhonda D , Malagon Maria M , Castano Justo P

The neuropeptide somatostatin (SRIF) exerts a wide variety of actions through five SRIF receptors (sst1-5). However, not all SRIF actions can be explained by activation of the known sst. In this context, our research group has identified two novel isoforms of sst subtype 5 (sst5A) named sst5B and sst5C expressed in human and pig. These isoforms are generated by splicing of cryptic introns within the coding sequence, which alters the open reading frame, and results in new, trun...

ea0016p464 | Neuroendocrinology | ECE2008

Posttraumatic hypopituitarism is associated with an unfavorable body composition and lipid profile, and decreased quality of life 12 months after injury

Klose Marianne , Watt Torquil , Brennum Jannick , Feldt-Rasmussen Ulla

Objective: To describe body-composition, lipid profile, and health-related quality of life (HRQL) in patients with traumatic brain injury (TBI) in relation to the development of posttraumatic hypopituitarism.Design: Cross-sectional with a nested prospective sub-study.Patients: The cross-sectional cohort included 104 hospitalized patients with TBI (26F/78M; age: median 41 years (range 18–64); BMI: 25 kg/m2 (17–3...

ea0016p465 | Neuroendocrinology | ECE2008

Gh/Igf-1 control and tumor growth reduction in active acromegalic patients on Octreotide LAR

Ilovayskaya Irena , Molitvoslovova Natalia , Egorova Olga , Dzeranova Larisa , Arapova Svetlana , Marova Evgenya

Prospective non-comparable randomized clinical investigation of GH/IGH-1 control and tumor growth reduction in active acromegalic patients on Octreotide-LAR is presented. Fifty patients (pts) with newly diagnosed acromegaly (primary teratment, group 1; mean age 47.8±13.9 years old) and 39 pts after previous surgical and/or radiological treatment (secondary treatment, group 2; mean age 48.1±12.2 years old) were treated with Ocrteotide LAR 20–40 mg every 4 weeks, ...

ea0016p466 | Neuroendocrinology | ECE2008

Effects of growth hormone replacement in 28 patients with growth hormone deficiency

Martin-Borge Virginia , Alvarez Escola Cristina , Lecumberri Santamaria Beatriz , Garcia Dominguez Maria , Moya Chimenti Elisa , Pallardo Sanchez Luis Felipe

Aim: To evaluate the response to growth hormone (GH) replacement in patients with growth hormone deficiency (GHD) after 1 year of treatment in terms of body composition, carbohydrate metabolism, lipid metabolism and quality of life.Method and patients: Twenty-eight patients with GHD with the following characteristics: 16 males, 10 with radiotherapy and 18 with panhypopituitarism, were included in our study. Body mass index (BMI) and waist hip ratio (WHR)...

ea0016p467 | Neuroendocrinology | ECE2008

Starting dose of 10 mg Octreotide-LAR appears ineffective for biochemical control in the majority of acromegalic patients: interim analysis from the OASIS trial

Petersenn Stephan , Tarasov Alexander , Gu Feng , Kim Sungwoon , Mercado Moises , Rogozinski Amelia , Bouterfa Hakim , David Kristin , Silva Antonio , Greenman Yona

Octreotide LAR (SMS-LAR) is available in 10, 20 and 30 mg dosing. The relation-ship between SMS-LAR starting dose and GH, IGF-I and symptoms was exam-ined. The Observational Acromegaly Study on Impact of Sandostatin LAR (OASIS) collects data on GH, IGF-I, symptoms, safety and tolerability in recently diagnosed acromegalic patients. Data are collected under normal practice conditions over 12 mos. Eight hundred and sixty patients from 138 centers in 23 countries are enrolled; 35...

ea0016p468 | Neuroendocrinology | ECE2008

Factors associated with response to medical therapy in patients with Acromegaly

Fernandez-Rodriguez Eva , Sherlock Mark , Aragon Alonso Aurora , Ayuk John , Clayton Richard N , Sheppard Michael C , Bates Andy , Stewart Paul M

Acromegaly is associated with increased morbidity and mortality. Surgery, radiotherapy (RT) and medical therapy are the treatment options to decrease GH and IGF-I concentrations to levels associated with cure or normalisation of mortality. We examined the response to dopamine agonists (DA) and somatostatin analogues (SSA) in 276 patients with acromegaly who received medical therapy during follow up (198 DA, 143 SSA). One hundred and seventy two had surgery and 73 RT prior to m...

ea0016p469 | Neuroendocrinology | ECE2008

Diagnosis of SIAD: Fractional urate excretion closes the diagnostic gap in hyponatremic patients on diuretics

Fenske Wiebke , Stork Stefan , Blechschmidt Anne , Allolio Bruno

Background: The syndrome of inappropriate antidiuresis (SIAD) is the most frequent cause of hyponatremia. Its diagnosis requires a decreased serum osmolality, urinary osmolality >200 mosm/kg, clinical euvolemia, and urinary sodium (UNa) >30 mmol/l. The natriuretic effect of diuretics impairs the diagnostic accuracy of UNa and thus, limits the diagnostic and therapeutic decision in hyponatremic patients substantially. We therefore examined the accuracy to predict SIAD o...

ea0016p470 | Neuroendocrinology | ECE2008

Circulating visfatin and adiponectin levels are reduced in women after long-term remission of Cushing's syndrome

Barahona Maria-Jose , Sucunza Nuria , Resmini Eugenia , Ricart Wifredo , Fernandez-Real Jose-Manuel , Rodriguez-Espinosa Jose , Webb Susan M

Metabolic syndrome and insulin resistance persist 5 years after remission of Cushing’s syndrome (CS). Adiponectin and visfatin are two adipokines highly expressed in adipose tissue. Adiponectin is reduced in obesity and insulin-resistant states; visfatin has been shown in some studies to be reduced in obesity. The aim was to evaluate visfatin and adiponectin levels, body composition, insulin resistance and prevalence of metabolic syndrome in a cohort of women with long-te...

ea0016p471 | Neuroendocrinology | ECE2008

The impact of conventional radiotherapy on Wisconsin card sorting test performance in acromegalic patients treated with transsphenoidal surgery

Lecumberri Beatriz , Estrada Javier , Garcia-Uria Jose , Alcaniz Julian , Pallardo Luis Felipe , Lucas Tomas

Neurocognitive dysfunction has been described in patients following pituitary radiotherapy. However, the relative contributions of other variables such as hormone-deficiency states and surgery is still unknown. Our aim was to compare the results of an examination of executive function in acromegalic patients treated with transsphenoidal surgery (TS) alone to those obtained from patients treated with TS followed by conventional radiotherapy (CR) using a two-field technique. We ...

ea0016p472 | Neuroendocrinology | ECE2008

Somatotropin release inhibiting factor (SRIF) downregulates Wnt/ß-catenin pathway in ACTH-secreting pituitary cell line AtT-20

Khattak Muhammad Nasir Khan , Kremenevskaya Natalia , Buchfelder Michael

Introduction: The involvement of the Wnt/ß-catenin pathway is apparent different epithelial human cancers. Wnt stabilizes ß-catenin (free ß-catenin) by preventing its phosphorylation which targets ß-catenin for degradation. Free ß-catenin is translocated to the nucleus where it stimulates a number of genes that modulate proliferation and differentiation upon binding to TCF/LEF-1. We have previously shown that Wnt/ß-catenin pathway is dysregulated ...

ea0016p473 | Neuroendocrinology | ECE2008

Identification of ACTH-secreting adenomas in Cushing's disease using intraoperative high-frequency direct contact ultrasound. Preleminary results

Knappe Ulrich , Konz Kornelia , Schoenmayr Robert , Mann Alexander , Engelbach Martin

Introduction: Up to 40% of cases with endocrinologically and surgically proven Cushing’s disease (CD) are MRI-negative1. With intraoperative transsphenoidal ultrasound 72% of microadenomas in CD were identified as hyperechogenic structure2. We report on the first 9 cases with intraoperative use of direct contact high-frequency ultrasound (hf-us) in patients with CD.Patients: All 9 cases (all female, age 31–71 years) reveal...

ea0016p474 | Neuroendocrinology | ECE2008

Macroprolactinaemia: a clinical problem

Kowalska Aldona , Gasior-Perczak Danuta , Palyga Iwona , Sluszniak Anna

Introduction: Prolactin is a hormone which is characterized with a high structural and functional polymorphism. Macroprolactin is one of the form of prolactin - it is a complex of monomeric prolactin and immunoglobulin. Macroprolactin is characterized with immunoreactivity and probably the lack of biological activity.Purpose: The main purpose of our study was to estimate the frequency of macroprolactin appearance among the patients with hyperpronactinaem...

ea0016p475 | Neuroendocrinology | ECE2008

Prolaktinoma and hyperprolactinemia in Albania

Ylli Agron , Ylli Zamira , Minga Malo , Fureraj Thanas , Husi Gerond , Xhumari Arian , Kaloshi Gentian , Alushani Merita , Lamcaj Entela , Olldashi Blertina

Background: Prolactin hyper secretion is the most common endocrine abnormality due to hypothalamic–pituitary disorders. PRL is the hormone most commonly secreted in excess by pituitary adenomas.Materials and methods: A retrospective study was performed during the period 1998–2007. The diagnose are based on objective examination, hormonal dosage, MRI.Results: During these time were diagnosed 98 cases with hyperprolactinemi...

ea0016p476 | Neuroendocrinology | ECE2008

Prospective comparison of the glucagon stimulation test (GST) with the insulin tolerance test (ITT) in patients following pituitary surgery

Berg Christian , Meinel Timo , Yuece Ali , Lahner Harald , Mann Klaus , Petersenn Stephan

Objective: The ITT is the gold-standard for assessment of GH and ACTH reserve but has certain contraindications. GH and cortisol responses of <3 ng/ml and <500 nmol/l, respectively, have been defined as evidence of severe deficiency. The GST like the ITT stimulates both the ACTH and GH secretion and is suggested to be a good alternative in terms of efficiacy. However, there are limited prospective data with modern assays on sensitivity and specificity for the GST in co...

ea0016p477 | Neuroendocrinology | ECE2008

Expression of ghrelin and opioid mRNAs in the hypothalamo–pituitary–adrenal axis after immune system activation

Pierzchala-Koziec Krystyna , Zubel Joanna

The activity of the hypothalamo–pituitary–adrenal axis (HPA) is under control of endocrine, nervous and immune systems, in which opioids and recently discovered ghrelin play important role. Mannan polysaccharide is often used as an alternatives to antibiotics, however, its role in the stimulation of the immune system is still uncertain. As a part of study dealing with the interaction of different factors during the growth and development the experiment was carried ou...

ea0016p478 | Neuroendocrinology | ECE2008

Cyclical Cushing's syndrome: prevalence in patients with Cushing's disease

Alexandraki Krystallenia I , Kaltsas Gregory A , Isidori Andrea M , Akker Scott A , Drake William M , Chew Shern L , Monson John P , Besser G Michael , Grossman Ashley B

Background: Cyclical Cushing’s syndrome has been considered to be a rare clinical entity, characterised by periodic increases in cortisol levels followed by regression of the Cushing’s syndrome. The cycles of hypercortisolism may occur before the establishment of the diagnosis, rendering actual diagnosis difficult, or may occur after inadequate or ineffective treatment and affect disease management. The aim of this study was to investigate the prevalence of cyclicity...

ea0016p479 | Neuroendocrinology | ECE2008

Familial acromegaly: family screening and assessment in the familial isolated pituitary adenoma (FIPA)

Fajardo Carmen , Daly Adrian , Trescoli Carlos , Camara Rosa , Riesgo Pedro , Gomez Jose , Beckers Albert

Familial acromegaly (FA) is a rare disease with less than 150 cases published. For its diagnosis (FA), two or more cases of acromegaly in the same family and the absence of MEN1 and/or Carney syndrome are required. FA is in the familial isolated pituitary adenomas (FIPA) group although its genetic condition is still under investigation.The index case is an asymptomatic 43-year-old woman with a 4mm pituitary micro-adenoma. There were not acromegaly signs/...

ea0016p480 | Neuroendocrinology | ECE2008

Hypopituitarism following traumatism brain injury in the West Indies: a pilot study between July 2005 and July 2006

Morineaux Sabine , Do Laurent , Simonetti Maurice , Salin Jacques , Foucan Patrick , Donnet Jean-Paul , Lalanne-Mistrih Marie-Laure

Sixty patients with traumatic brain injury are newly diagnosed every year in our island, particularly in patients with addictive behaviours. In France, it is the 4th rank of health expenses, as a major issue of public health care. In order to perform a first endocrine assessment, we performed a pilot study to diagnose traumatic brain injury induced hypopituitarism, assessed at least 6 months after injury, in moderate to severe traumatic brain injuries patients, hospitalized in...

ea0016p481 | Neuroendocrinology | ECE2008

Hypopituitarism after traumatic brain injury and its possible relation with neurocognitive and psychiatric disturbances

Castro Ana I , Lage Mary , Peino Roberto , Lorenzo Monica , Casanueva Felipe

Introduction: Recent advances in medicine have allowed a considerably decrease in mortality after traumatic brain injury (TBI) with the consequent increment in the number of subjects with physical, psychological and cognitive sequelas which means an important worsening of quality of life as well as difficulties in social and labour integration. Considering that many of the symptoms classically attributed to the TBI (memory impairment, concentration impairment, fatigue, social ...

ea0016p482 | Neuroendocrinology | ECE2008

Endoscopic pituitary surgery as the primary treatment for acromegaly: a prospective study in a specialised centre

Faustini-Fustini Marco , Magrini Satima , Anagni Mascia , Mazzatenta Diego , Pasquini Ernesto , Frank Giorgio

The main aims of treatment of acromegaly are reversing symptoms and signs, removing the tumour, preventing disease recurrence, and improving survival. Increased mortality associated with acromegaly can be diminished if treatment is successful in reducing GH <2–2.5 ng/ml. We carried out a prospective study to assess whether recent advances in surgical technique (namely the endoscopic approach in a specialised centre encompassing specialist pituitary surgeons working in...

ea0016p483 | Neuroendocrinology | ECE2008

mTOR inhibitors rapamycin and RAD001 (Everolimus) induce antiproliferative effects in GH3 cell line and human pituitary adenomas

Rubinfeld Hadara , Gorshtein Alexander , Kendler Efrat , Hadani Moshe , Shimon Ilan

The effect of mTOR inhibitors on pituitary tumors is unknown. Akt overexpression was demonstrated in pituitary adenomas, which may render them sensitive to the antiproliferative effects of these drugs.To evaluate the in vitro effects of mTOR inhibitor rapamycin, and its orally-bioavailable analog RAD001 on pituitary cells, GH3 cells, a mammosomatotroph rat pituitary tumor cell line, and human GH-secreting and non-functioning pituitary adenoma (NFP...