Searchable abstracts of presentations at key conferences in endocrinology
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10th European Congress of Endocrinology

Poster Presentations

Growth factors

ea0016p362 | Growth factors | ECE2008

Does IGF-BP3 assay contribute to the diagnosis of GHD in children?

Kayemba-Kay's Simon , Epstein Sophie , Burguet Antoine , Ingrand Pierre , Hankard Regis

Background: Diagnosing GDH in children remains matter of debate due to variability in results obtained with pharmacological tests, one child may fail one test, but pass another. Spontaneous GH secretion assessment is costly, time consuming, and results may show poor correlations with those obtained with provocative tests. To add to diagnosic power of provocative tests, testing IGF-I and IGF-PB3 have been suggested. In recent years, however, the contribution of IGF-PB3 assay to...

ea0016p363 | Growth factors | ECE2008

Does administration of octreotide acetate prevent development of diabetic nephropathy? an ultrastructural evaluation of the effects of octreotide acetate on kidney tisssue in Streptozotocin induced diabetic rats

Bahceci Selen , Nergiz Yusuf , Bahceci Mithat , Akkus Murat

Background and aims: Growth hormone and insulin-like growth factors to be involved in the pathogenesis of diabetic kidney disease. The aim of this study was ultrastructural evaluation of octreotide acetate on kidney tissue in streptozotocin (STZ) induced diabetic rats.Material and methods: Twenty-four male Spraque–Dawley rats divided into 3 groups; control (C), diabetic (D) and diabetic with octreotide aceatate (DO). The all diabetic rats were treat...

ea0016p364 | Growth factors | ECE2008

Measurement of neutralising antibodies to human interferon-β by quantitative analysis of type 1 interferon inducible 6–16 mRNA

Moore Melanie , Meager Anthony , Wadhwa Meenu , Burns Chris

Therapeutic interferon-β (IFN-β) preparations have been approved for treatment for multiple sclerosis (MS). However, the development of neutralising antibodies (NAbs) against IFN-β in MS patients reduces therapeutic efficacy. Early detection of NAbs is critical for the modification of treatment regimes. IFN-β exerts its biological effects by binding to receptors on target cells and stimulating the expression of IFN-β-inducible genes. Measurement of end...

ea0016p365 | Growth factors | ECE2008

Association between serum levels of insulin-like growth factor-I and development of congestive heart failure: a prospective study in a normal population

Andreassen Mikkel , Raymond Ilan , Kistorp Caroline , Hildebrandt Per , Faber Jens

Background: The growth hormone system (growth hormone, GH and insulin-like-growth-factor I, IGF-I) might be implicated in congestive heart failure (CHF). In experimental models IGF-I increases cardiac contractility and reduces apoptosis of myocytes exposed to ischemic injury. In clinical studies GH-therapy has been used in CHF. One previous population based investigation showed that low levels of IGF-I was associated with an increased incidence of CHF. The result of this inves...

ea0016p366 | Growth factors | ECE2008

Effects of growth hormone and of insulin-like growth factor-I on iron-induced lipid peroxidation in rat liver and porcine thyroid homogenates

Kokoszko Agnieszka , Dabrowski Jan , Szosland Janusz , Lewinski Andrzej , Karbownik-Lewinska Malgorzata

Bivalent iron (Fe2+), which initiates the Fenton reaction (Fe2++H2O2+H+→Fe3++•OH+H2O), is frequently used to experimentally induce oxidative damage to macromolecules. Growth hormone (GH) and the main mediator of its action – insulin-like growth factor-I (IGF-I) – are involved in oxidative processes, lipid peroxidation (LPO) included.The aim of the...

ea0016p367 | Growth factors | ECE2008

Protective effects of growth hormone and of insulin-like growth factor-I against lipid peroxidation in iron sensitive rat tissue

Kokoszko Agnieszka , Dabrowski Jan , Szosland Janusz , Lewinski Andrzej , Karbownik-Lewinska Malgorzata

Iron participates in the Fenton reaction (Fe2++H2O2+H+→Fe3++•OH+H2O), the most basic reaction of oxidative stress. This transition metal is required to keep oxidative balance, although iron overload is associated with enhanced oxidative damage and cancer initiation. Growth hormone (GH) and insulin-like growth factor-I (IGF-I) are also involved in oxidative processes, lipid peroxidation incl...

ea0016p368 | Growth factors | ECE2008

Leptin and ghrelin serum levels during an oral glucose tolerance test in patients with growth hormone deficiency with and without growth hormone substitution

Roemmler Josefine , Kuenkler Maren , Otto Baerbel , Bidlingmaier Martin , Schopohl Jochen

In GH deficiency (GHD), fat mass is elevated compared to normal subjects. Leptin is positively related to fat mass, BMI and food intake, while ghrelin correlates negatively. During an oral glucose tolerance test (OGTT), leptin increases in obese subjects and generally does not change in normal weight subjects. Ghrelin decreases during OGTT. We performed a cross-sectional study in order to investigate the influence of GH-substitution on leptin and ghrelin in GHD.<p class="a...

ea0016p369 | Growth factors | ECE2008

New occurrence of diabetes mellitus in patients with adult onset GH deficiency (GHD) on GH therapy is dependent on the presence of metabolic syndrome at baseline: data from the Hypopituitary Control and Complication Study (HypoCCS)

Attanasio Andrea , Mo Daojun , Chanson Philippe , Ho Ken , Woodmansee Whitney , Kleinberg David , Erfurth Eva Marie

Patients with adult onset GHD (AO-GHD) manifest features of the metabolic syndrome (MetS) (abdominal obesity, dyslipidemia and insulin resistance), a condition associated with increased risk of diabetes mellitus (DM).We assessed metabolic status before and after 2 years of GH treatment and the occurrence of de novo DM in 712 patients with AO-GHD from HypoCCS drawn from the US (32.2%) and Europe (67.8%). Patients were divided into four BMI categori...

ea0016p370 | Growth factors | ECE2008

Associations of anthropometric parameters with serum IGF-1, TSH, prolactin and testosterone levels

Friedrich Nele , Steveling Antje , Nauck Matthias , Brabant Georg , Volzke Henry , Wallaschofski Henri

Background: Obesity is a major risk factor for the development of chronic diseases and a determinant of cardiovascular disease. Divergent associations between obesity and hormonal changes have been reported. The objective of the present study was to analyse the associations between different anthropometric measurements and serum hormone levels including insulin-like growth factor 1 (IGF-1), thyroid-stimulation hormone (TSH), prolactin, and testosterone.M...

ea0016p371 | Growth factors | ECE2008

The cytosine-adenine (CA) repeat polymorphism in the promoter region of the insulin-like growth factor-1 (IGF-1) gene is not associated with the GH dose in GH-deficient adults

Meyer Silke , Bruck Carolin , Ivan Diana , Kohler Ute , Schafer Stephan , Arp Pascal , van der Lely Aart J , Uitterlinden Andre G , Kann Peter H

Objective: A cytosine-adenine (CA)n microsatellite repeat polymorphism in the promoter region of the insulin-like growth factor-1 (IGF-1) gene has reported to be associated with IGF-1 serum levels, birth weight, body height, bone mineral density and risk for type 2 diabetes and myocardial infarction. Carriers and non-carriers of the most frequent allele (length 192 base pairs (bp)) showed significantly different total IGF-1 serum levels. This polymorphism may direct...

ea0016p372 | Growth factors | ECE2008

Acromegaly is associated with high plasma fibrinogen and C reactive protein values after normalization of growth hormone and IGF-1

Friedrich Nele , Nonnenberg Dennis , Spilcke-Liss Elisabeth , Volzke Henry , Dorr Marcus , Wallaschofski Henri

Background: Acromegaly is associated with increased morbidity and mortality from cardiovascular disease. Several studies indicate that reduction of growth hormone (GH) to <1 μg/l or normalization of serum IGF-I reduces mortality to expected levels. Inflammatory markers, such as C-reactive protein (CRP) or haemostatic markers, such as fibrinogen have emerged as important cardiovascular risk markers in the general population.Objective and design: ...

ea0016p373 | Growth factors | ECE2008

Low insulin-like growth factor (IGF) I, IGF binding protein-3 and acid labile subunit (ALS) levels in young ischemic stroke: a prospective case-control study

Di Somma Carolina , Savanelli Maria Cristina , Tufano Antonella , Rota Francesca , Di Minno Dario Nicola , D'Andrea Marianna , Lombardi Gaetano , Minno Giovanni Di , Colao Annamaria

Animal and observational studies suggest that the IGF axis is involved in the pathogenesis of ischemic stroke; moreover, endogenous IGF-I could influence the evolution of ischemic stroke in humans and thereby contribute to an improved clinical and functional outcome. To assess and correlate the IGF-I axis with biochemical parameters in young patients experiencing ischemic stroke (32 aged 15–45 years,19F, BMI: 25.5±3.4 kg/m2), we evaluated IGF-I, IGFBP-3, A...

ea0016p374 | Growth factors | ECE2008

Pituitary hormone axes in constitutionally tall adolescents

Melnitchenko Galina , Koloda Dmitry , Pronin Vyacheslav , Tiulpakov Anatoly , Gitel Evgeny , Ordzhonikidze Zurab , Pavlov Vladimir , Preobrazhensky Vladimir

Objective: To evaluate the pituitary hormone axes in adolescents with constitutional tall stature (CTS).Materials and methods: About 120 patients (54 males and 66 females) with CTS aged 9.6–16.5 years (13.6±2.7 years, mean±S.D.) were enrolled in this study. Sixty-eight normal subjects (24 males and 44 females) aged 9.8–16.2 years (13.1±2.1 years), who were comparable in socioeconomic and nutritional terms, served a...

ea0016p375 | Growth factors | ECE2008

TIMP-1 regulates the secretion of soluble VEGF receptor 1 in human endothelial cells

Neulen Joseph , Motejlek Karin

Objectives: Vascular endothelial growth factor (VEGF) and its soluble receptor (sVEGFR-1) are key regulators in human ovarian angiogenesis. VEGF promotes blood vessel growth while sVEGFR-1 is a VEGF antagonist. A promising candidate in sVEGFR-1 regulation is TIMP-1 (tissue inhibitor of metalloproteinases 1), which is involved in extracellular matrix remodelling. The aim of our research is to determine if TIMP-1 influences sVEGFR-1 secretion in endothelial cells.<p class="a...

ea0016p376 | Growth factors | ECE2008

Overexpression of IGFBP-2 in transgenic mice affects muscle protein accretion, skeletal myofibre growth and metabolism

Rehfeldt C , Renne U , Wolf E , Hoflich A

To elucidate the functional role of IGFBP-2 for in vivo skeletal muscle growth and function, skeletal muscle cellularity and metabolism as well as body growth and composition have been studied in a transgenic mouse model overexpressing IGFBP-2. Postnatal growth rate of transgenic mice (n=20) was clearly reduced from day 21 of age by 6–8% (P<0.05) compared with non-transgenic controls (n=37). At the final day of live (day 72 of age) body pro...