Searchable abstracts of presentations at key conferences in endocrinology
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10th European Congress of Endocrinology

Poster Presentations

Growth and development

ea0016p348 | Growth and development | ECE2008

Secular height changes in Greek conscripts

Fytanidis Grigorios , Papadimitriou Anastasios , Papadimitriou Dimitrios , Fytanidis Iakovos , Nicolaidou Polyxeni

Introduction: In some developed countries, the acceleration of physical development has already reached a plateau.Objective: Aim of our study was to examine whether an improvement of the body height of adult men is still observed in Greece and to correlate the body height with socio-economic and demographic factors.Research methods and procedures: The height of 3068 Greek conscripts, aged 18–26 years, was measured and analyzed...

ea0016p349 | Growth and development | ECE2008

Population-based data of quality of life assessment of growth hormone deficiency in adults (QoL-AGHDA)

Moock Joern , Albrecht Christin , Voelzke Henry , Nauck Matthias , Koltowska-Haggstrom Maria , Kohlmann Thomas , Wallaschofski Henri

Objective: Age- and gender-specific reference values for quality of life (QoL) measures are important to assess the impact of growth hormone deficiency (GHD). The objective of this study was to develop population-based data for the QoL-AGHDA instrument for Germany and to compare this data with corresponding Qol-AGHDA scores of the German KIMS cohort during growth hormone treatment, to investigate the association between the Qol-AGHDA score and the IGF-1 values in the German KI...

ea0016p350 | Growth and development | ECE2008

A study of IGF-1 serum concentrations and kinetics of growth hormone assays in stimulation tests used for diagnosing insufficient somatotrope secretion

Monge Marie

Introduction: The diagnosis of insufficient somatotrope secretion (growth hormone deficiency or GHD) is important in children.In France, a child is considered to have a deficit if no serum GH concentrations greater than 20 mIU/l are recorded in 2 different stimulation tests. One of the tests must be ‘coupled’, i.e. combining 2 pharmacological agents.However, this 20 mIU/l threshold does not take account of the type of tes...

ea0016p351 | Growth and development | ECE2008

45,X/46,XX mosaicism: clinical implications in adulthood

Homer Lionel , Le Martelot Marie-Therese , Morel Frederic , Collet Michel , De Braekeleer Marc , Kerlan Veronique

Introduction: Turner syndrome is well known, but prognosis for 45,X/46,XX mosaicism under 30% of aneuploidy has not been established. We realised a retrospective study among women aged 21–43 years, to evaluate differences in clinical features and biological parameters between patients who had sex chromosome mosaicism diagnosed incidentally and controls women.Material and methods: Among infertile population, 71 women with sex chromosome mosaicism (45...

ea0016p352 | Growth and development | ECE2008

Evaluation of insulin sensitivity in growth hormone (GH) deficient children before and at the end of rhGH therapy

Savastio Silvia , Bellone Simonetta , Bellone Jaele , Zanetta Fiorella , Di Dio Giuseppina , Giacoma Sara , Petri Antonella , Prodam Flavia , Corneli Ginevra , Bona Gianni , Aimaretti Gianluca

Introduction: Therapy with recombinant GH (rhGH) allows GH-deficient children (GHD) to reach an adequate adult stature. Previous studies have reported a significant rise in serum insulin levels during GH therapy. It has been demonstrated that insulin resistance is a risk factor for the development of DMT2, atherosclerosis, dyslipidemia and hypertension.Subjects and methods: Aim of our study was to evaluate changes in insulin sensitivity in a group of GHD...

ea0016p353 | Growth and development | ECE2008

Impaired Se metabolism provokes gender-specific growth defects in mice

Renko Kostja , Chadt Alexandra , Michaelis Marten , Schweizer Ulrich , Al-Hasani Hadi , Kohrle Josef , Schomburg Lutz

Background: Selenoproteins are involved in oxidative stress defence, cell signalling and hormone metabolism. Accordingly, impairment of selenium (Se) metabolism or transport results in a complex phenotype as exemplified in selenoprotein P knockout mice (SePP-KO). This mouse model is characterized by a disrupted metabolism of Se resulting in neurological and growth defects. Hypothesis: Se impairs regular tissue development by modifying growth signal biosynthesis, anabolic respo...

ea0016p354 | Growth and development | ECE2008

Potential ageing effects in long-term cultured mouse neurospheres

Vukicevic Vladimir , Gebauer Linda , Jauch Anna , Ziegler Christian , Krug Alexander , Chung Kuei-Fang , Funk Richard , Bornstein Stefan , Mueller Albrecht , Ehrhart-Bornstein Monika

Neural cells are isolated from forebrain of 14.5 days old mouse embryos. In selective conditions these cells cluster forming sphere-like structures – neurospheres (NSCs). NSCs are heterogeneous structures containing only 2–5% of stem cells and progenitors being reportedly capable to transdifferentiate. Initially, aim of this study is to establish optimal culture conditions prior to investigation of transdifferentiation capacity of transplanted NSCs in kidney and adre...

ea0016p355 | Growth and development | ECE2008

Health-related quality of life in constitutionally tall children and adolescents

Melnitchenko Galina , Koloda Dmitry , Pronin Vyacheslav , Tiulpakov Anatoly

Objective: To evaluate the health-related quality of life (HRQoL) in children and adolescents with constitutional tall stature (CTS).Materials and methods: Sixty-two patients (20 males and 42 females) with CTS aged 9.3–16.4 years (12.9±2.4 years, mean±S.D.) were enrolled in this study. Sixty-eight normal subjects (24 males and 44 females) aged 9.8–16.2 years (13.1±2.1 years) served as controls. The evaluation of th...

ea0016p356 | Growth and development | ECE2008

Utility of 2-h nocturnal assessment of growth hormone (GH) secretion as a screening procedure in diagnosing GH deficiency in short children: own observations

Smyczynska Joanna , Hilczer Maciej , Stawerska Renata , Lewinski Andrzej

Background: Nocturnal profile of GH secretion is proposed to be a screening diagnostic procedure for GH deficiency (GHD) in short children. Every screening procedure must be characterised by very high sensitivity and good specificity. The data concerning the cut-off level between normal and subnormal nocturnal GH secretion are scarce and non-consistent.The aim of the study was to assess the clinical utility of 2-h nocturnal profile of GH secretion in dia...

ea0016p357 | Growth and development | ECE2008

Abstract withdrawn...

ea0016p358 | Growth and development | ECE2008

Comparison between the results of 2-h and 6-h assessment of nocturnal growth hormone (GH) secretion in short children - preliminary report

Hilczer Maciej , Smyczynska Joanna , Stawerska Renata , Lewinski Andrzej

Background: Assessment of nocturnal GH secretion is useful tool in diagnosing GH deficiency (GHD) in children. The time period of the evaluation, the number of blood samples, as well as the choice of cut-off value for this examination – are still the matter for discussion.Aim: The aim of the study was to compare the results of 2-h and 6-h assessment of nocturnal GH secretion in children with suspected neurosecretory dysfunction of GH secretion (NSD)...

ea0016p359 | Growth and development | ECE2008

Lipid peroxidation as possible mechanism of apoptosis activation in low birth weight children

Barg Ewa , Gasiorowski Kazimierz , Wikiera Beata , Skoczynska Anna , Turczyn Barbara , Wojcik Elzbieta , Grabowski Marcin

Children born with low birth weight (LBW, below 2500 g) exhibit slower development with deficit of height susceptibility to recurrent infections, especially of respiratory tract and, in adulthood, an increased risk of developing syndrome X. One possible explanation could be an enhanced elimination of cells by apoptosis.The aim of this study was evaluate of mechanism of lipid peroxidation and activity of caspase 3 in children with low birth weight.<p ...

ea0016p360 | Growth and development | ECE2008

Study of dimer and oligomers of human growth hormone

Junnila Riia , Wu Zida , Strasburger Christian

There is a high heterogeneity of human growth hormone (hGH), variation rising from the different genes in pituitary and placenta, alternative splicing, post-translational modifications, oligomerization and binding to the growth hormone binding protein (GHBP). Distinguishing between different variants remains problematic and there is still quite little information about the proportion of these variants in circulation of both healthy individuals and of patients with growth hormo...

ea0016p361 | Growth and development | ECE2008

Changes in cortisol and insulin during pregnancy in relation to basal metabolic rate (BMR)

Damjanovic Svetozar , Stojic Rada , Lalic Nebojasa , Petakov Milan , Jotic Aleksandra , Isailovic Tanja , Popovic Bojana , Macut Djuro , Bozic Ivana

Cortisol rise during pregnancy is connected with fetal maturation. Together with the increase of insulin resistance it might have a role in allocation of nutrients between mother and fetus. Cortisol and insulin secretion during pregnancy seems to be induced by fluctuations in BMR. Here, we try to identify relationship between BMR and secretion of cortisol and insulin during pregnancy.In 25 healthy women (age range 20–39 years; mean±S.D.<...