Endocrine Abstracts

Exon 1 of the androgen receptor (AR) gene contains a variable number of CAG triplets, (CAGr)n which encode a polyglutamine stretch of variable length in the N-terminal domain of the receptor. Experimental evidence has accumulated in demonstrating that the length of this stretch influences the transcriptional activity induced by the AR and therefore modulates target organs responsiveness to androgens.The (CAGr)n is inversely associated with the transcript...