Searchable abstracts of presentations at key conferences in endocrinology

ea0092ps1-10-01 | Basic Thyroid Gland, Iodine & Autoimmunity Basic | ETA2023

Targeting interleukin-11 signaling, an emerging patholgical mediator in thyroid eye disease

Swaney James , Jun Toni , Elliott Eric , Lu Ivan , Geller Shira , Chai Merrick , Witherden Deborah , Arora Puneet , Silkiss Rona , King David

Objectives: Thyroid eye disease (TED) is considered a fibroinflammatory disease with pathology related to both inflammatory and fibrotic disease processes. IL-11 is a fibroinflammatory cytokine that is linked to tissue fibrosis of the lung, skin, heart, kidney and liver. Recently, IL-11 was identified as a possible disease modifier in TED. IL-11 levels are increased in TED patient plasma, in correlation with disease severity, and IL-11 stimulates phenotypic switching of orbita...