Endocrine Abstracts

Adrenal carcinomas are rare with a poor prognosis, highlighting the importance of prompt investigation of adrenal incidentalomas. We report a challenging case of an adrenocortical carcinoma secreting steroids in a pattern characteristic of 21-hydroxylase deficiency, which also proved to be a histopathological enigma. A 36-year-old woman underwent investigation for right-sided loin pain. A CT showed an avidly heterogeneously enhancing circumscribed left adrenal mass measuring 6...

Introduction: Multi-modal therapy for adrenocortical carcinoma (ACC) includes surgery, therapy with the adrenolytic agent mitotane and systemic chemotherapy. Achievement of therapeutic mitotane concentrations (≥14 mg/l) has been related to improved outcomes.Aim: To evaluate the effectiveness of a defined* high dose protocol mitotane therapy in patients with advanced ACC (stages III and IV).Methods: Review of patients presenti...