Searchable abstracts of presentations at key conferences in endocrinology

ea0063p500 | Calcium and Bone 2 | ECE2019

Body mass index is a biomarker of resistance to active vitamin D but not to calcium supplementation, in patients with hypoparathyroidism

Tecilazich Francesco , Formenti Anna Maria , Frara Stefano , Resmini Eugenia , Doga Mauro , Giubbini Raffaele , Giustina Andrea

Background: Persistent Hypoparathyroidism (PH) is a condition characterized by inappropriately low concentrations of PTH that lead to hypocalcemia. The treatment cornerstones of PH are calcium and calcitriol supplementation; however, several patients do not achieve adequate control of the disease under this conventional therapy. Notably, no biomarker of risk of ‘resistance’ has yet been identified. Based on the fact that obesity alters the vitamin D-calcium homeostas...

ea0049oc10.3 | Bone & Calcium Homeostasis | ECE2017

High prevalence of radiological vertebral fractures in patients with differentiated thyroid carcinoma undergoing L-thyroxine TSH-suppressive therapy

Formenti Anna Maria , Mazziotti Gherardo , Frara Stefano , Maffezzoni Filippo , Doga Mauro , Bertagna Francesco , Maroldi Roberto , Memo Maurizio , Giubbini Raffaele , Giustina Andrea

Thyroid hormones play a central role in the regulation of bone turnover and thyrotoxicosis is an established cause of secondary osteoporosis. Increased prevalence of reduced bone mineral density (BMD) has been reported even in patients with subclinical thyrotoxicosis such as those with differentiated thyroid carcinoma undergoing long-term L-thyroxine (L-T4) TSH-suppressive therapy. Morphometric vertebral fractures (VFs) are an early and clinically...

ea0049gp231 | Thyroid Cancer | ECE2017

Management and outcome of bone metastasis from differentiated thyroid carcinoma in the real life: the M.OS.CA.TI. study

Mazziotti Gherardo , Panarotto Maria Beatrice , Arvat Emanuela , Chiti Arturo , Cuocolo Alberto , Dottorini Massimo , Elisei Rossella , Filetti Sebastiano , Filice Angelina , Formenti Anna Maria , Pace Leonardo , Pellegrino Teresa , Nodari Marcello , Salvatori Massimo , Tranfaglia Cristina , Versari Annibale , Frara Stefano , Berruti Alfredo , Giustina Andrea , Giubbini Raffaele

Although differentiated thyroid cancer (DTC) has the third highest propensity to spread to the bone after breast and prostate cancer, there is a paucity of data concerning the treatment of bone metastasis (BM) in this setting. The MOSCATI (Metastasi OSsee da Carcinoma TIroideo) was a multicenter, retrospective study investigating the real-life outcome and management of BM in 143 patients (80 F, 63 M; median age 60 years) with DTC involving 10 specialized cente...