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19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

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20-23 May 2017, Lisbon, Portugal Further information

Guided Posters

Thyroid Cancer

ea0049gp225 | Thyroid Cancer | ECE2017

Prognostic factors for intrathyroidal papillary carcinomas – a multivariate analysis

Santrac Nada , Markovic Ivan , Goran Merima , Buta Marko , Djurisic Igor , Dzodic Radan

Introduction: The aim of this study was to examine prognostic significance of patient-related, tumor-related and treatment-related factors for intrathyroidal papillary thyroid carcinomas (PTC), via multivariate analysis.Materials and methods: This study included 153 patients with intrathyroidal PTCs (pT1/pT2/pT3) surgically treated in our Institution during two-decade period. Patients with locally invasive tumors (pT4) and initial distant metastases (M1)...

ea0049gp226 | Thyroid Cancer | ECE2017

Malignancy Rate in Thyroid Nodules: Cytology versus Histology in challenging categories

Silvestre Catarina , Luis Rita , Bugalho Maria Joao , de Almeida Margarida Mendes , Carvalho Raquel

Background: To stratify the risk of malignancy, thyroid fine-needle aspiration cytology (FNAC) is an important and cost-effective method to evaluate nodules. The Bethesda System for Reporting Thyroid Cytopathology III, IV and V categories are diagnostic challenges, falling between benign and malignant.Objective: Determinate the malignancy rates of thyroid nodules classified as Bethesda Categories III-V.Methods: Retrospective study ...

ea0049gp227 | Thyroid Cancer | ECE2017

Fine needle aspiration biopsy in pediatric patients with thyroid nodules

Costa Maria Manuel , Silva Rita Santos , Castro-Correia Cintia , Sucesso Maria Bom , Coelho Tiago Henriques , Barroca Helena , Fontoura Manuel

Introduction: Although thyroid nodules (TN) are less common in children than in adults, the risk of malignancy is much higher in pediatric age and therefore representing greater concern in this age group.Objective: Evaluate a cohort of pediatric patients with TN and search differences between subjects with malignant and benign TN regarding sex, age, compressive symptoms, cervical ultrasound characteristics, family history of differentiated thyroid cancer...

ea0049gp228 | Thyroid Cancer | ECE2017

Differentiated thyroid cancer – comparison between patients with and without remission

Amado Ana , Gouveia Patricia , Pereira Teresa Alves , Castro Rosa , da Costa Antonio Moreira , Carvalho Andre , Freitas Claudia , Borges Fatima

Introduction: Differentiated thyroid cancer (DTC) is one of the most frequent forms of malignancy. Because of its favourable outcome and low mortality rates, identifying prognostic factors has been a challenge. Several risk stratification systems have been developed. Most of them include demographic and tumour specific features, as well as extrathyroidal extension. Our objective was to compare clinical characteristics between DTC patients with and without remission.<p clas...

ea0049gp229 | Thyroid Cancer | ECE2017

Trends in papillary microcarcinoma prevalence in North of Portugal

Pereira Teresa Alves , Amado Ana , Gouveia Patricia , Castro Rosa , da Costa Antonio Moreira , de Carvalho Andre Couto , Freitas Claudia , Borges Fatima

Introduction and Objectives: The incidence of thyroid cancer has increased worldwide. This increase has been attributed to more diagnosed papillary thyroid microcarcinomas. The purpose of this study was to analyse the growing trend of first appointments in our Thyroid Cancer Unit, namely patients with papillary microcarcinomas.Methods: We performed a retrospective study based on the patients diagnosed with thyroid cancer between 1960 and 2016. We divided...

ea0049gp230 | Thyroid Cancer | ECE2017

Radioiodine (RAI) refractory differentiated thyroid cancer (DTC): outcome and prognostic factors for DISEASE progression

Saltiki Katerina , Simeakis George , Anagnostou Elli , Apostolakis Michalis , Zapanti Evangelia , Anastasiou Eleni , Alevizaki Maria

Introduction: Patients diagnosed with DTC have excellent prognosis. A small percentage of patients with disease persistence do not respond to treatment with RAI (RAI-refractory DTC) and have low median survival (3.5 years). We investigated the prognostic factors and the disease course in patients with RAI-refractory DTC.Methods: Of all DTC patients (n=1160) followed-up in our department in recent years, 800 received RAI treatment and were classified in 2...

ea0049gp231 | Thyroid Cancer | ECE2017

Management and outcome of bone metastasis from differentiated thyroid carcinoma in the real life: the M.OS.CA.TI. study

Mazziotti Gherardo , Panarotto Maria Beatrice , Arvat Emanuela , Chiti Arturo , Cuocolo Alberto , Dottorini Massimo , Elisei Rossella , Filetti Sebastiano , Filice Angelina , Formenti Anna Maria , Pace Leonardo , Pellegrino Teresa , Nodari Marcello , Salvatori Massimo , Tranfaglia Cristina , Versari Annibale , Frara Stefano , Berruti Alfredo , Giustina Andrea , Giubbini Raffaele

Although differentiated thyroid cancer (DTC) has the third highest propensity to spread to the bone after breast and prostate cancer, there is a paucity of data concerning the treatment of bone metastasis (BM) in this setting. The MOSCATI (Metastasi OSsee da Carcinoma TIroideo) was a multicenter, retrospective study investigating the real-life outcome and management of BM in 143 patients (80 F, 63 M; median age 60 years) with DTC involving 10 specialized cente...

ea0049gp232 | Thyroid Cancer | ECE2017

Germ-line mutations in RET-790 and RET-791 codons (exon 13) among subjects with sporadic medullary thyroid cancer

Katalinic Darko , Solter Miljenko , Nikolac Nora

Background: Medullary thyroid carcinoma (MTC) is a rare calcitonin producing neuroendocrine tumour that originates from parafollicular C-cells of the thyroid gland. RET proto-oncogene germline mutations are crucial for the onset and the progression of MTC, and the occurrence of single nucleotide polymorphisms could predispose the clinical course of disease. The objective of this study was to evaluate possible differences in clinical presentation among patients with/without RET...

ea0049gp233 | Thyroid Cancer | ECE2017

Comparison of clinicopathological features in patients with familial and sporadic papillary thyroid cancer

Dellal Fatma Dilek , Ozdemir Didem , Aydin Cevdet , Ogmen Berna , Kilicarslan Aydan , Kilic Mehmet , Ersoy Reyhan , Cakir Bekir

Introduction: Although, familial medullary thyroid cancer is a known condition, familial papillary thyroid cancer (PTC) is a rare and less well described clinical entity. While some studies suggest more aggressive features in familial PTC, some do not support these findings. We aimed to compare ultrasonographical, cytopathological and histopathological results of patients with familial and sporadic PTC.Methods: Data of 194 patients diagnosed with PTC his...

ea0049gp234 | Thyroid Cancer | ECE2017

Lobectomy as a treatment option for well differentiated thyroid cancer (WDTC) between 1–4 cm: which results should we expect?

Fareleira Ana , Ferreira Patricia Andrea , Lima L Matos , Maia J Costa

Introduction: The ATA guidelines 2015 suggests lobectomy as an option for low risk thyroid tumors between 1–4 cm, although there remains some controversy once some characteristics become apparent only on pathologic examination.Objective/methods: Retrospective analysis of patients who underwent thyroid surgery in 2014 and 2015, with a histologic diagnosis of WDTC 1–4 cm in size and revision of the proportion of patients eligible for lobectomy wi...

ea0049gp235 | Thyroid Cancer | ECE2017

Clinical Utility of response to therapy in combination with BRAF in risk assessment of thyroid cancer

Fernandez Laura Perez , De la Vieja Escolar Antonio , Zafon Carles , Galofre Juan Carlos , Riesco-Eizaguirre Garcilaso , Spanish Task Force for the study of BRAF SEEN Garcilaso

Response to therapy re-stratification approach has been recently included in the 2015 ATA guidelines as a risk-adapted approach to management of thyroid cancer. Our aim was to investigate the clinical utility of response to therapy variables obtained during early follow-up in combination with BRAF, a prominent oncogene in thyroid cancer with prognostic value. This was a retrospective multicenter study of 871 patients at 11 centers in Spain with papillary thyroid cancer followe...