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19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

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20-23 May 2017, Lisbon, Portugal Further information

Guided Posters

Thyroid Cancer & Thyroid Case Reports

ea0049gp236 | Thyroid Cancer & Thyroid Case Reports | ECE2017

A rare case of medullary thyroid cancer, mesothelioma and meningioma, due to APC and RASAL1 mutations

Lyssikatos Charalampos , Quezado Martha M , Faucz Fabio R , Angelousi Anna , Nasiri-Ansari Narjes , Stratakis Constantine A , Kassi Eva

Introduction: Patients with “mixed” phenotypes are common among patients with multiple endocrine and non-endocrine neoplasias. Their diagnoses do not fit a given pattern making ge netic counseling difficult and testing impossible to guide. Most of these patients end up getting genome-wide studies for the identification of any predisposing genetic defect. We present a rare case of a 57 year old female who presented clinically with medullary thyroid cancer (MTC), mesot...

ea0049gp237 | Thyroid Cancer & Thyroid Case Reports | ECE2017

Thyrotoxic Periodic Paralysis due to Graves’ disease: a mandatory differential diagnosis in Asian patients presenting with paralysis and hypokalemia

Barbosa David , Faria Carolina , Osorio Ana Sofia , Nobre Ema , Vilas Ana Paula , Bugalho Maria Joao

Introduction: Thyrotoxic periodic paralysis (TPP) is a potentially life-threatening complication of hyperthyroidism that is underdiagnosed and frequently missed. It is relatively common in Asian men with Graves’ disease. TPP attacks are frequently associated with hypokalemia.Case presentation: We describe a 26-year-old Asian male with an unremarkable past medical history who was admitted following sudden onset of flaccid paralysis of the lower extre...

ea0049gp238 | Thyroid Cancer & Thyroid Case Reports | ECE2017

A fatal case of fetal goiter: autoimmunity is the key

Berges-Raso Irene , Albert Lara , Caixas Assumpta , Capel Ismael , Cano Albert , Mazarico Isabel , Serra Laura , Corona Manuel , Martinez Cesar Martin , Rigla Mercedes

Introduction: Fetal goiter is an infrequent and potentially life-threating condition derived from either fetal hypothyroidism or hyperthyroidism. TSH-receptor stimulating antibodies (TSH-R-ABs) can cross the placenta and induce fetal hyperthyroidism and goiter. We describe a rare case of TSH-R-ABs-induced hyperthyroidism in a woman with autoimmune hypothyroidism (AH) without previous hyperthyroidism.Case Report: A 28 years old pregnant woman under treatm...

ea0049gp239 | Thyroid Cancer & Thyroid Case Reports | ECE2017

Renal cell carcinoma metastasis to thyroid tumor: a case report

Faria Carolina , Barbosa David , Osorio Ana Sofia , Nobre Ema , Bugalho Maria Joao

Introduction: Subacute thyroiditis (SAT) association with papillary thyroid carcinoma (PTC) has been rarely reported in the literature. Metastatic neoplasms to the thyroid are rare in clinical practice. Renal cell carcinomas (RCC) are the most frequent site of origin of thyroid metastases (12 to 34%). Tumor-to-tumor metastases, in which a thyroid neoplasm is the recipient of a metastasis, are exceedingly rare. Tuberous sclerosis (TS) is associated with several renal manifestat...

ea0049gp240 | Thyroid Cancer & Thyroid Case Reports | ECE2017

Giant goiter with intrathyroid arteriovenous fistula as a cause of severe pulmonary hypertension

Mesa Elena Marquez , Melo Estefania Gonzalez , Gonzalez Cristina Lorenzo , Marquez Pilar Olvera , Garzon Ricardo Darias , Arranz Maria Teresa Herrera , Bray Bruno Francisco Garcia , Huerta Yolanda Zambrano , Abizanda Enrique Palacio

Introduction: Hyperthyroidism has been described as a rare cause of pulmonary hypertension (PH) as well as systemic arteriovenous fistulas. However, we describe a case of pulmonary hypertension secondary to an intrathyroid arteriovenous fistula, not previously described in the literature.Case report: A 56 year old woman followed in our consultations with multinodular goiter and a long standing hyperthyroidism, secondary to Graves Basedow disease with dif...

ea0049gp241 | Thyroid Cancer & Thyroid Case Reports | ECE2017

Thyroid-related adverse events in patients treated with Nivolumab

Peiro I , Martin L San , Simo-Servat A , Otero J , Ruffinelli JC , Nadal E , Iglesias P , Diez JJ , Villabona C

Introduction: Nivolumab is an antibody that binds to and blocks the activation of programmed-death-receptor 1(PD-1), promoting the activation of T-cells against tumor cells. Thyroid dysfunction (TD) is one of the most common immuno-related adverse events, with incidence up to 10% in patients treated with PD-1/PD-L1 blockade.Objective: To report our experience of Nivolumab-TD in patients with advanced cancer.Methods: All patients di...

ea0049gp242 | Thyroid Cancer & Thyroid Case Reports | ECE2017

False negative fine needle aspiration thyroid cytology: an institutional experience

Martins Anabela , Mendonca Evelina , Garrao Antonio , Marques Hugo , Cid Maria , Rosario Francisco , Veiga Ricardo , Catarino Ana

Introduction: Fine needle aspiration cytology (FNA) is the most accurate diagnostic method for thyroid malignant nodule diagnosis. According to the literature, the percentage of false negative results (FN-FNA) is less than 1.5%, in tertiary health care centers.In this study we describe the cases reported in this Hospital, between 2014 and 2016, of benign cytology, histologically characterized as malignant. All pathologic specimens were reviewed.<p cl...

ea0049gp243 | Thyroid Cancer &amp; Thyroid Case Reports | ECE2017

Risk factors associated with malignancy in thyroid nodules classified as Bethesda category IV (follicular neoplasm/suspicious for follicular neoplasm)

Kuru Bekir , Kefeli Mehmet

Background: Thyroid nodules diagnosed as Bethesda category IV (follicular neoplasm/suspicious for follicular neoplasm (FN/SFN)) are recommended for surgery. However, only 25% of these nodules turn to be malignant on histopathology. Therefore, selection of nodules for surgery diagnosed as Bethesda category IV is important. We aimed at to define the predictive factors for malignancy and predictive risk indices for selection of surgery.Method: The records o...

ea0049gp244 | Thyroid Cancer &amp; Thyroid Case Reports | ECE2017

Expressions of miRNAs and BRAFV600E mutation detection in papillary thyroid carcinoma

Simanaviciene Vaida , Kondrotiene Aiste , Pamedytyte Daina , Sarauskas Valdas , Dauksiene Dalia , Dauksa Albertas , Zvirbliene Aurelija , Zilaitiene Birute

Introduction: Papillary thyroid carcinoma (PTC) is the most common type of thyroid malignancy. For the majority of patients with PTC, the prognosis is very good; however, up to 20% of patients suffer disease recurrence. Currently, the risk stratification for PTC recurrence is based on clinicopathological features which have limited prognostic value. Identification of molecular biomarkers of PTC recurrence such as protooncogene BRAF and miRNAs may help to improve risk-stratifie...

ea0049gp245 | Thyroid Cancer &amp; Thyroid Case Reports | ECE2017

A statistical, in silico model predicts polygenic thyroid cancer risk

Casarini Livio , Marino Marco , Nuzzo Federico , Simoni Manuela , Brigante Giulia

Introduction: The detection of a unique genetic marker is not possible for multifactorial diseases, such as thyroid cancer (TC), where the pathological phenotype is given by the contribution of multiple genes, environmental factors and lifestyle. We found a mathematical model for inferring the risk of thyroid cancer, an example of multifactorial disease.Methods: Genetic data represented by 184 SNPs associated to thyroid tumors were used for Bayesian clus...