Endocrine Abstracts

Introduction: Hybrid closed loop (HCL) therapy has been shown to improve the glycaemic control in children and adolescents with Type 1 Diabetes. There is however limited data comparing the HCL therapy with conventional insulin pump therapy. We aimed to retrospectively compare the outcomes of hybrid closed loop (Tandem T slim) and conventional insulin pumps.Methodology: Electronic patient records for all the patients using insulin pump therapy at Sheffiel...

Introduction: Hypocalcemia is a well known adverse reaction of phosphate supplements but rarely reported. We report a case of Infant presenting with hypocalcemic seizures after initiation of phosphate supplements.Clinical case: A baby Girl was born at 34+4 weeks gestation. She was admitted in NNU for preterm care. The admission was complicated by severe Gastroesophageal reflux disease(confirmed by PH impedance study), anemia and sepsis. She was discharge...

Background: Limited data support concerns that corticosteroid use in pregnancy, for maternal health reasons, can suppress the neonatal Hypothalamic-Pituitary-Adrenal (HPA) axis. We sought to determine if neonates born to mothers on high-dose steroids are at risk of adrenal suppression.Methodology: Our tertiary neonatal unit guidance advises that babies born to mothers receiving ≥7.5 mg/day prednisolone for 28 consecutive days in the 3rd trimester u...

Background: There are multiple indications for evaluation of the Hypothalamic-pituitary-adrenal (HPA) axis in neonates e.g. hypoglycaemia, hypotension, conjugated hyperbilirubinemia; however permanent neonatal adrenal insufficiency (AI) is rare. Interpretation of results can be challenging due to a paucity of normative reference data in this population. This risks overdiagnosis and unnecessary treatment with corticosteroids leading to the associated iatrogenic harm, including ...