Endocrine Abstracts

Introduction: Hashimoto’s thyroiditis (HT) is caused by a variety of genes, cytokines, receptors, and environmental factors. A series of enzymes known as type 1 and type 2 deiodinases (D1, D2) are in charge of converting thyroxine (T4) into triiodothyronine (T3). It is believed that the low free T3 (fT3) levels caused by D2 polymorphism may result in thyroid autoimmunity through the induction of inflammation. However, iodothyronine deiodinase (DIO) gene polymorphism and H...

Introduction: Adverse pregnancy outcomes have been associated with maternal thyroid dysfunction. However, optimizing the best threshold value to improve maternal and perinatal outcomes and alleviate complications by establishing population-based gestation-specific reference intervals (RIs) instead of using recommended universal cut-off values, especially for thyroid-stimulating hormone (TSH), is still an ongoing debate. The aim of this study was to compare the prevalence and r...