Endocrine Abstracts

A 31-year-old gentleman presented to our Endocrine Services with his 20-year-old fiancée with plans for marriage and to conceive. He was diagnosed with congenital panhypopituitarism and absent pituitary stalk at the age of 4. He was started on replacement growth hormone, desmopressin, levothyroxine, hydrocortisone and testosterone, in this sequence, across the years. He underwent induction of puberty at the age of 13 years. He was noticed to have bilateral cryptorchidism ...

An 84-year-old lady presented with a month’s history of polyuria and polydipsia. She reported waking up seven times during the night to pass urine and constantly feeling thirsty. Her measured 24-hour urine output was 4.9 L. She was otherwise doing well with a past medical history of hypertension, hyperlipidaemia, gastro-oesophageal reflux disease and prolonged hospital admission 20 years ago for Guillain Barré syndrome. Her drug history included Lisinopril, Atorvasta...

Introduction: Granulomatous myositis (GM) is a very rare inflammatory condition and can cause PTH- independent hypercalcemia. The hypercalcaemia is due to the elevated levels of extrarenal 1,25 dihydroxy vitamin D produced by activated macrophages due to granulomatous inflammation. We present a case of very severe hypercalcemia due to GM.Case presentation: An 82-year-old lady presented to the emergency department due to deterioration in renal function an...

Introduction: Hyperthyroid Graves’ Disease affects 3% of women and 0.5% of men over a lifetime, with only 50% of patients experiencing remission following antithyroid drug therapy. The humoral immune response involves the production of Thyroid Stimulating Hormone Receptor antibodies (TRAbs) from plasma cells. This study aims to provide proof of principle that Daratumumab, a monoclonal antibody targeting cell-surface CD-38 on plasma cells, could modulate the immune respons...

Background: The published data on the natural history of (presumed) non-functioning pituitary microadenomas (micro-NFAs) is possibly compromised by small sample sizes, short follow-up and inclusion of cases with other pathologies in the analyses.Objective: To clarify the long-term outcomes of micro-NFAs in a large cohort of patients.Methods: We conducted a multi-centre, retrospective, cohort study involving 22 UK endocrine departme...

Background: Large series of patients elucidating the natural history of conservatively managed non-functioning pituitary macroadenomas (macroNFPAs) and relevant prognostic factors are not available.Objectives: Clarify long-term outcomes of macroNFPAs in large cohort of patients.Methods: Multi-centre [21 UK endocrine departments-UK NFPA consortium], retrospective, cohort study of ca...