Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep801 | Nuclear receptors and Signal transduction | ECE2017

18β-glycyrrhetinic acid reduces VLDL secretion as a modulator for HNF4α

Liu Qingli , Yang Meng , Zhang Minyi , Guan Min

Glycyrrhizin (GL) is a major bioactive triterpene glycoside of licorice root, a traditional Chinese herbal medicine. GL and primary metabolite 18β-glycyrrhetinic acid (GA) have been developed as anti-inflammatory and antiviral drugs for liver diseases in China and Japan. Hepatic VLDL secretory pathway is not only responsible for lipid homeostasis but also associated with viral particles assembly and secretion. Hepatocyte nuclear factor 4α (HNF4α) together with i...

ea0090rc8.1 | Rapid Communications 8: Calcium and Bone | ECE2023

Targeting adipocyte ESRRA rebalances bone and marrow adipocyte homeostasis through opposite regulation of LEPTIN and SPP1

Huang Tongling , Wang Zihui , Lu Zhaocheng , Gao Lu , Gao Jun , Cheng Lixin , Guan Min

Osteoporosis is a progressive disease characterized by excessive bone loss which is often accompanied by augments in marrow adiposity as a result of estrogen deficiency, metabolic abnormalities or medications. Nuclear receptor estrogen-related receptor alpha (ESRRA) has a demonstrated role in energy homeostasis and fat metabolism. To determine if ESRRA is a potential therapeutic target for regulating fat-bone balance, we generated an adipocyte-specific ESRRA knockout mice (ESR...