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ea0020p552 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

The D3 GH receptor polymorphism is associated with osteoarthritis, especially of the hip, in patients with long-term cured acromegaly

Wassenaar Moniek JE , Biermasz Nienke R , van der Klaauw Agatha A , Smit Johannes WA , Pereira Alberto M , Roelfsema Ferdinand , van der Straaten Tahar , Kroon Herman M , Kloppenburg Margreet , Guchelaar HJ , Romijn Johannes A

Objective: To evaluate the impact of the genomic deletion of exon 3 in the growth hormone receptor (d3GHR) on co-morbidities of acromegaly in a well-characterized cohort of patients with long-term remission of acromegaly.Design: Cross sectional study.Methods: The presence of the d3GHR polymorphism was assessed in 86 acromegalic patients and related to clinical outcome, i.e. anthropometric parameters, osteoarthritis, and the metabol...

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The D3 GH receptor polymorphism is associated with osteoarthritis, especially of the hip, in patients with long-term cured acromegaly

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