Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep989 | Thyroid (non-cancer) | ECE2016

Increased Serum Levels of IL-28 and IL-29 and Protective Effect of IL28B rs8099917 Polymorphism in Patients with Hashimoto’s Thyroiditis

Arpaci Dilek , Celik Sevim Karakas , Can Murat , Gunes Gunes Cakmak , Kuzu Fatih , Unal Mustafa , Bayraktaroglu Taner

Hashimoto’s thyroiditis is thought to result from the decreased of T helper type 2 (Th2) responses, leading to progressive destruction of thyrocytes. IFN-λ1, -λ2, and -λ3 (also known as IL-29, IL-28A, and IL-28B, respectively) is a recently described member of the IFN-λ family and has been shown to decrease production of Th2 cytokines in vitro. However, the role and mechanism of IFN-λ1 in Hashimoto’s thyroiditis remain unkno...